Development Level

Tbio 37 | 11,445

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal embryo size 3 | 220
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
abnormal craniofacial morpholo... 1 | 33
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal forebrain morphology 1 | 10
abnormal hindbrain development 1 | 16
abnormal hindbrain morphology 1 | 10
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
anophthalmia 1 | 33
decreased circulating glucose ... 1 | 126
embryonic growth retardation 1 | 106
hemorrhage 1 | 23
increased circulating aspartat... 1 | 15
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
microphthalmia 1 | 26
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499

Disease

ovarian cancer 26 | 8,520
medulloblastoma, large-cell 21 | 6,241
osteosarcoma 19 | 7,950
Carcinoma 18 | 11,493
atypical teratoid / rhabdoid tumor 18 | 5,112
glioblastoma 17 | 5,792
pancreatic cancer 14 | 2,398
ulcerative colitis 14 | 1,819
group 3 medulloblastoma 13 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
lung cancer 13 | 4,740
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
lung adenocarcinoma 12 | 2,716
non-small cell lung cancer 12 | 2,890
psoriasis 12 | 6,694
Acrodermatitis enteropathica 11 | 18
active Crohn's disease 11 | 922
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
Breast cancer 10 | 3,578
colon cancer 10 | 1,478
ependymoma 10 | 4,679
malignant mesothelioma 10 | 3,232
Endometriosis 9 | 540
acute quadriplegic myopathy 9 | 1,158
cystic fibrosis 9 | 1,696
primary pancreatic ductal adenocarcinoma 9 | 1,109
invasive ductal carcinoma 8 | 2,951
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
adrenocortical carcinoma 7 | 1,428
adult high grade glioma 7 | 3,801
breast carcinoma 7 | 1,638
diabetes mellitus 7 | 1,728
astrocytic glioma 6 | 2,597
lung carcinoma 6 | 2,843
oligodendroglioma 6 | 2,850
primitive neuroectodermal tumor 6 | 3,035
tuberculosis 6 | 2,010
Alzheimer's disease 5 | 658
Astrocytoma, Pilocytic 5 | 3,081
Multiple myeloma 5 | 1,332
interstitial cystitis 5 | 2,312
Acquired metabolic disease 4 | 336
Down syndrome 4 | 499
Liver Cirrhosis, Experimental 4 | 769
Respiratory Hypersensitivity 4 | 19
ductal carcinoma in situ 4 | 1,745
esophageal adenocarcinoma 4 | 737
pituitary cancer 4 | 1,972
Autosomal recessive predisposition 3 | 1,442
Bladder Neoplasm 3 | 112
Neoplasm Invasiveness 3 | 161
Schizophrenia 3 | 1,160
Urinary Bladder Neoplasms 3 | 114
Waldenstrons macroglobulinemia 3 | 765
dermatomyositis 3 | 966
facioscapulohumeral dystrophy 3 | 288
head and neck cancer 3 | 271
juvenile dermatomyositis 3 | 1,187
nephrosclerosis 3 | 333
subependymal giant cell astrocytoma 3 | 2,287
Acrodermatitis 2 | 5
Alzheimer Disease 2 | 83
Bipolar Disorder 2 | 666
Breast Neoplasms 2 | 445
Cancer 2 | 2,499
Carcinoma, Hepatocellular 2 | 228
Duchenne muscular dystrophy 2 | 601
Dystonia 2 | 164
Epidermodysplasia verruciformis 2 | 21
Esophageal Neoplasms 2 | 69
Hepatomegaly 2 | 285
Insulinoma 2 | 24
Kidney cancer 2 | 2,613
Liver carcinoma 2 | 240
Mammary Neoplasms 2 | 425
Neoplasm Metastasis 2 | 168
Neurodegenerative disease 2 | 414
Osteoarthritis 2 | 184
Parkinson's disease 2 | 392
Pick disease 2 | 1,894
Prostatic Neoplasms 2 | 495
Respiratory Distress Syndrome, Adult 2 | 40
Rheumatoid arthritis 2 | 1,191
Seizures 2 | 596
Tremor 2 | 113
Troyer syndrome 2 | 5
Type 2 diabetes mellitus 2 | 272
acute myeloid leukemia 2 | 783
astrocytoma 2 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
cutaneous lupus erythematosus 2 | 1,057
group 4 medulloblastoma 2 | 1,855
nasopharyngeal carcinoma 2 | 1,058
non primary Sjogren syndrome sicca 2 | 891
pediatric high grade glioma 2 | 1,064
primary Sjogren syndrome 2 | 735
spina bifida 2 | 1,074
Abnormal blistering of the skin 1 | 54
Barrett's esophagus 1 | 182
Skin bulla 1 | 54

Tissue

Digestive Tract 36 | 17,369
Endocrine System 36 | 18,159
Nervous System 35 | 16,725
Skin and soft tissues 35 | 17,230
Female tissues 34 | 17,400
Liver and Pancreas 33 | 16,750
Male tissues 33 | 17,142
Respiratory system 33 | 16,393
Blood and immune system 32 | 16,909
Urinary Tract 31 | 16,678
Cardiovascular System 29 | 15,192

Target Family

Transporter 24 | 473
Non-IDG 12 | 12,091
Transcription Factor 1 | 1,400

WikiPathways Pathway

Zinc homeostasis 37 | 37
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc transporter ZIP3 SLC39A3 Tbio Transporter -0.52290 3.15 87
Zinc transporter 1 SLC30A1 Tbio Transporter -2.12639 135.9 148
Zinc transporter ZIP10 SLC39A10 Tbio Transporter -1.20558 16.3 102
Metal regulatory transcription factor 1 MTF1 Tbio Transcription Factor -1.98140 101.0 135
Zinc transporter 9 SLC30A9 Tbio Transporter -0.88627 10.1 105
Zinc transporter 2 SLC30A2 Tbio Transporter -1.59498 39.4 26
Zinc transporter 3 SLC30A3 Tbio Transporter -2.01559 111.7 67
Zinc transporter ZIP6 SLC39A6 Tbio Transporter -1.66663 50.0 172
Metallothionein-1A MT1A Tbio Non-IDG -2.03652 104.6 39
Metallothionein-1E MT1E Tbio Non-IDG -1.43264 41.6 29