Development Level

Tbio 29 | 11,445
Tchem 7 | 1,598

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal heart morphology 3 | 162
decreased vertical activity 3 | 208
decreased startle reflex 2 | 75
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
abnormal bone mineralization 1 | 38
abnormal brain morphology 1 | 13
abnormal eye morphology 1 | 68
abnormal eye size 1 | 7
abnormal head morphology 1 | 10
abnormal kidney morphology 1 | 65
abnormal startle reflex 1 | 15
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
edema 1 | 59
hydroencephaly 1 | 14
hydrometra 1 | 53
hydrops fetalis 1 | 1
impaired glucose tolerance 1 | 75
increased bone mineral density 1 | 72
increased circulating insulin ... 1 | 3
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
mammalian phenotype 1 | 17
microphthalmia 1 | 26
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
small heart 1 | 10
small superior vagus ganglion 1 | 74

Disease

Carcinoma 30 | 11,493
Cancer 20 | 2,499
psoriasis 18 | 6,694
ovarian cancer 17 | 8,520
osteosarcoma 16 | 7,950
atypical teratoid / rhabdoid tumor 14 | 5,112
glioblastoma 13 | 5,792
ependymoma 12 | 4,679
group 3 medulloblastoma 12 | 4,104
medulloblastoma, large-cell 12 | 6,241
Breast cancer 11 | 3,578
Osteoporosis 9 | 363
interstitial cystitis 9 | 2,312
Astrocytoma, Pilocytic 8 | 3,081
Autosomal recessive predisposition 8 | 1,442
lung cancer 8 | 4,740
malignant mesothelioma 7 | 3,232
primitive neuroectodermal tumor 7 | 3,035
Hypoplastic mandible condyle 6 | 275
Mandibular hypoplasia 6 | 275
Micrognathism 6 | 275
acute myeloid leukemia 6 | 783
adult high grade glioma 6 | 3,801
astrocytic glioma 6 | 2,597
breast carcinoma 6 | 1,638
ductal carcinoma in situ 6 | 1,745
invasive ductal carcinoma 6 | 2,951
non-small cell lung cancer 6 | 2,890
oligodendroglioma 6 | 2,850
Cognitive delay 5 | 608
Global developmental delay 5 | 608
Kidney disease 5 | 430
Mental and motor retardation 5 | 608
Obesity 5 | 678
Short stature 5 | 531
Vascular disease 5 | 319
cystic fibrosis 5 | 1,696
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
lung adenocarcinoma 5 | 2,716
lung carcinoma 5 | 2,843
osteoporosis-pseudoglioma syndrome 5 | 9
pituitary cancer 5 | 1,972
tuberculosis 5 | 2,010
Cleft Palate 4 | 271
Congenital diaphragmatic hernia 4 | 67
Cryptorchidism 4 | 296
Disease Models, Animal 4 | 155
Dull intelligence 4 | 645
Intellectual disability 4 | 1,016
Kidney cancer 4 | 2,613
Long philtrum 4 | 137
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Orbital separation excessive 4 | 244
Poor school performance 4 | 645
Robinow syndrome 4 | 11
Schizophrenia 4 | 1,160
adrenocortical carcinoma 4 | 1,428
fibroadenoma 4 | 559
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
non primary Sjogren syndrome sicca 4 | 891
pancreatic cancer 4 | 2,398
pediatric high grade glioma 4 | 1,064
posterior fossa group A ependymoma 4 | 468
Big calvaria 3 | 147
Broad flat nasal bridge 3 | 236
Congenital clinodactyly 3 | 57
Congenital hypoplasia of lung 3 | 48
Congenital hypoplasia of penis 3 | 176
Crohn's disease 3 | 321
Curvature of digit 3 | 57
Frequent fractures 3 | 53
Frontal bossing 3 | 157
Hypotrophic malar bone 3 | 129
Increased fracture rate 3 | 53
Increased head circumference 3 | 147
Increased size of cranium 3 | 147
Increased size of skull 3 | 147
Infantile onset 3 | 238
Lung disease 3 | 142
Malar flattening 3 | 129
Nasal bridge wide 3 | 236
Parkinson's disease 3 | 392
Pick disease 3 | 1,894
Prostatic Neoplasms 3 | 495
Reperfusion Injury 3 | 86
Stomach Neoplasms 3 | 300
Thin upper lip vermilion 3 | 67
Tooth agenesis 3 | 44
Uterine Cervical Neoplasm 3 | 25
Uterine Cervical Neoplasms 3 | 26
Varying degree of multiple fractures 3 | 53
colon cancer 3 | 1,478
cutaneous lupus erythematosus 3 | 1,057
diabetes mellitus 3 | 1,728
medulloblastoma 3 | 720
subependymal giant cell astrocytoma 3 | 2,287
ulcerative colitis 3 | 1,819

Tissue

Digestive Tract 35 | 17,369
Female tissues 35 | 17,400
Blood and immune system 34 | 16,909
Endocrine System 34 | 18,159
Male tissues 34 | 17,142
Nervous System 34 | 16,725
Skin and soft tissues 34 | 17,230
Urinary Tract 33 | 16,678
Liver and Pancreas 32 | 16,750
Respiratory system 31 | 16,393
Cardiovascular System 27 | 15,192

Target Family

Non-IDG 23 | 12,091
GPCR 9 | 408
Kinase 3 | 634
Enzyme 1 | 4,145

WikiPathways Pathway

Wnt Signaling in Kidney Diseas... 36 | 36
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein Wnt-6 WNT6 Tbio Non-IDG -1.65830 46.6 186
Frizzled-7 FZD7 Tbio GPCR -1.81873 66.4 345
Low-density lipoprotein receptor-related protein 5 LRP5 Tbio Non-IDG -3.10429 1247.5 302
Protein Wnt-7b WNT7B Tbio Non-IDG -1.76807 52.2 46
Frizzled-9 FZD9 Tbio GPCR -1.77240 61.8 380
Protein Wnt-2b WNT2B Tbio Non-IDG -1.76988 58.0 172
Protein Wnt-10a WNT10A Tbio Non-IDG -2.66153 436.3 118
Protein Wnt-5b WNT5B Tbio Non-IDG -1.62833 40.2 161
Frizzled-8 FZD8 Tbio GPCR -1.64874 42.5 233
Inversin INVS Tbio Non-IDG -2.10471 129.2 47