Development Level

Tbio 61 | 11,445
Tchem 37 | 1,598
Tclin 2 | 613
Tdark 1 | 6,588

Collection

GPCR: IDG Consortium (Targets) 1 | 126
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 12 | 979
abnormal heart morphology 4 | 162
decreased vertical activity 4 | 208
abnormal behavior 3 | 298
abnormal bone structure 3 | 187
decreased body length 3 | 101
decreased bone mineral content 3 | 151
embryonic lethality prior to t... 3 | 278
enlarged heart 3 | 210
abnormal head morphology 2 | 10
abnormal startle reflex 2 | 15
decreased bone mineral density 2 | 126
decreased circulating total pr... 2 | 49
decreased grip strength 2 | 116
decreased lean body mass 2 | 135
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular vol... 2 | 79
decreased neutrophil cell numb... 2 | 42
decreased startle reflex 2 | 75
embryonic lethality prior to o... 2 | 239
hypoactivity 2 | 132
impaired glucose tolerance 2 | 75
increased bone mineral density 2 | 72
increased circulating iron lev... 2 | 30
increased erythrocyte cell num... 2 | 39
increased fasted circulating g... 2 | 76
increased hematocrit 2 | 46
increased lymphocyte cell numb... 2 | 32
increased mean corpuscular vol... 2 | 92
male infertility 2 | 123
mammalian phenotype 2 | 17
microphthalmia 2 | 26
preweaning lethality, incomple... 2 | 499
short tibia 2 | 97
abnormal body wall morphology 1 | 9
abnormal bone mineralization 1 | 38
abnormal brain morphology 1 | 13
abnormal embryo development 1 | 7
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal eye size 1 | 7
abnormal eyelid fusion 1 | 3
abnormal facial morphology 1 | 17
abnormal forelimb morphology 1 | 2
abnormal head shape 1 | 10
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal limb morphology 1 | 13
abnormal locomotor behavior 1 | 24
abnormal response to tactile s... 1 | 17
abnormal testis morphology 1 | 43
anophthalmia 1 | 33
cataract 1 | 92
corneal opacity 1 | 32
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased body weight 1 | 161
decreased cardiac muscle contr... 1 | 11
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased circulating unsatura... 1 | 2
decreased erythrocyte cell num... 1 | 62
decreased heart left ventricle... 1 | 28
decreased heart weight 1 | 27
decreased mean corpuscular hem... 1 | 31
decreased mean platelet volume 1 | 25
decreased prepulse inhibition 1 | 82
decreased total body fat amoun... 1 | 207
edema 1 | 59
hydroencephaly 1 | 14
hydrometra 1 | 53
increased B cell number 1 | 9
increased bone mineral content 1 | 108
increased cardiac muscle contr... 1 | 8
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating choleste... 1 | 66
increased circulating fructosa... 1 | 13
increased circulating insulin ... 1 | 3
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 36
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
polydactyly 1 | 7
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
protruding tongue 1 | 3
small heart 1 | 10
small superior vagus ganglion 1 | 74
small testis 1 | 58
syndactyly 1 | 23

Disease

Carcinoma 81 | 11,493
psoriasis 61 | 6,694
ovarian cancer 60 | 8,520
Cancer 56 | 2,499
osteosarcoma 53 | 7,950
atypical teratoid / rhabdoid tumor 49 | 5,112
glioblastoma 48 | 5,792
medulloblastoma, large-cell 47 | 6,241
ependymoma 41 | 4,679
Breast cancer 35 | 3,578
group 3 medulloblastoma 33 | 4,104
lung cancer 33 | 4,740
oligodendroglioma 32 | 2,850
primitive neuroectodermal tumor 30 | 3,035
Astrocytoma, Pilocytic 27 | 3,081
astrocytic glioma 27 | 2,597
adult high grade glioma 26 | 3,801
lung adenocarcinoma 26 | 2,716
Kidney cancer 25 | 2,613
invasive ductal carcinoma 24 | 2,951
malignant mesothelioma 24 | 3,232
non-small cell lung cancer 24 | 2,890
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 23 | 2,989
lung carcinoma 23 | 2,843
interstitial cystitis 20 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 20 | 3,291
subependymal giant cell astrocytoma 20 | 2,287
breast carcinoma 19 | 1,638
Schizophrenia 18 | 1,160
Pick disease 17 | 1,894
ductal carcinoma in situ 17 | 1,745
group 4 medulloblastoma 17 | 1,855
pancreatic cancer 17 | 2,398
colon cancer 16 | 1,478
Prostatic Neoplasms 15 | 495
Rheumatoid arthritis 15 | 1,191
Stomach Neoplasms 15 | 300
pituitary cancer 15 | 1,972
tuberculosis 15 | 2,010
cystic fibrosis 14 | 1,696
Vascular disease 13 | 319
pediatric high grade glioma 13 | 1,064
Bipolar Disorder 12 | 666
Colonic Neoplasms 12 | 142
adrenocortical carcinoma 12 | 1,428
diabetes mellitus 12 | 1,728
Autosomal recessive predisposition 11 | 1,442
Colorectal Neoplasms 11 | 243
Hypoplastic mandible condyle 11 | 275
Mandibular hypoplasia 11 | 275
Micrognathism 11 | 275
astrocytoma 11 | 1,146
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
Cognitive delay 10 | 608
Global developmental delay 10 | 608
Intellectual disability 10 | 1,016
Lung Neoplasms 10 | 232
Mental and motor retardation 10 | 608
Obesity 10 | 678
acute myeloid leukemia 10 | 783
ulcerative colitis 10 | 1,819
Atopic dermatitis 9 | 952
Endometrial cancer 9 | 311
Epilepsy 9 | 792
Lymphoid leukemia 9 | 160
Multiple myeloma 9 | 1,332
Neurodegenerative disease 9 | 414
Orbital separation excessive 9 | 244
Osteoporosis 9 | 363
Seizures 9 | 596
Short stature 9 | 531
Waldenstrons macroglobulinemia 9 | 765
esophageal adenocarcinoma 9 | 737
gastric carcinoma 9 | 807
spina bifida 9 | 1,074
Adenocarcinoma 8 | 122
Adenoma 8 | 167
Alzheimer's disease 8 | 658
Cleft Palate 8 | 271
Crohn's disease 8 | 321
Dull intelligence 8 | 645
Immune system cancer 8 | 140
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Poor school performance 8 | 645
hepatocellular carcinoma 8 | 547
nasopharyngeal carcinoma 8 | 1,058
Carcinoma, Hepatocellular 7 | 228
Kidney disease 7 | 430
Liver carcinoma 7 | 240
Muscle hypotonia 7 | 571
Parkinson's disease 7 | 392
Ventricular Septal Defects 7 | 119
active ulcerative colitis 7 | 764
acute quadriplegic myopathy 7 | 1,158
cutaneous lupus erythematosus 7 | 1,057
dermatomyositis 7 | 966
fibroadenoma 7 | 559

Tissue

Digestive Tract 100 | 17,369
Female tissues 100 | 17,400
Endocrine System 99 | 18,159
Male tissues 99 | 17,142
Skin and soft tissues 99 | 17,230
Blood and immune system 98 | 16,909
Nervous System 98 | 16,725
Urinary Tract 97 | 16,678
Liver and Pancreas 96 | 16,750
Respiratory system 94 | 16,393
Cardiovascular System 90 | 15,192

Target Family

Non-IDG 37 | 12,091
Enzyme 18 | 4,145
Kinase 18 | 634
Transcription Factor 14 | 1,400
GPCR 10 | 408
Epigenetic 2 | 242
Nuclear Receptor 2 | 48

WikiPathways Pathway

Wnt Signaling Pathway and Plur... 101 | 101
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein Wnt-6 WNT6 Tbio Non-IDG -1.65830 46.6 186
Forkhead box protein D3 FOXD3 Tbio Transcription Factor -2.69659 482.7 180
Steroid hormone receptor ERR2 ESRRB Tchem Nuclear Receptor -1.95523 86.9 173
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Frizzled-7 FZD7 Tbio GPCR -1.81873 66.4 345
Low-density lipoprotein receptor-related protein 5 LRP5 Tbio Non-IDG -3.10429 1247.5 302
Fos-related antigen 1 FOSL1 Tbio Transcription Factor -2.39870 235.8 243
C-terminal-binding protein 2 CTBP2 Tchem Non-IDG -2.63977 410.7 251
Protein Wnt-7b WNT7B Tbio Non-IDG -1.76807 52.2 46