Development Level

Tbio 40 | 10,625
Tchem 24 | 1,890
Tclin 2 | 602

Collection

GPCR: IDG Consortium (Targets) 1 | 127
Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

preweaning lethality, complete... 3 | 633
decreased startle reflex 2 | 48
short tibia 2 | 82
abnormal behavior 1 | 226
abnormal bone mineralization 1 | 55
abnormal embryo size 1 | 112
abnormal head morphology 1 | 10
abnormal startle reflex 1 | 14
abnormal testis morphology 1 | 30
decreased caudal vertebrae num... 1 | 49
decreased grip strength 1 | 123
decreased lumbar vertebrae num... 1 | 62
hydrops fetalis 1 | 22
impaired glucose tolerance 1 | 52
increased bone mineral density 1 | 52
increased circulating alanine ... 1 | 11
increased circulating alkaline... 1 | 119
increased circulating aspartat... 1 | 17
increased circulating iron lev... 1 | 25
increased erythrocyte cell num... 1 | 26
increased hematocrit 1 | 36
male infertility 1 | 62
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
preweaning lethality, incomple... 1 | 260
small testis 1 | 37

Disease

ovarian cancer 43 | 8,491
psoriasis 42 | 6,685
osteosarcoma 38 | 7,933
medulloblastoma, large-cell 35 | 6,234
Cancer 34 | 2,346
glioblastoma 32 | 5,572
atypical teratoid / rhabdoid tumor 29 | 4,369
oligodendroglioma 21 | 2,849
Breast cancer 20 | 3,098
primitive neuroectodermal tumor 20 | 3,031
lung adenocarcinoma 19 | 2,714
ependymoma 18 | 2,514
lung cancer 18 | 4,473
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,956
non-small cell lung cancer 17 | 2,798
pilocytic astrocytoma 17 | 3,086
interstitial cystitis 16 | 2,299
pediatric high grade glioma 16 | 2,712
group 3 medulloblastoma 14 | 2,254
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,988
lung carcinoma 14 | 2,844
astrocytoma 13 | 1,493
invasive ductal carcinoma 13 | 2,950
Carcinoma 12 | 2,147
cystic fibrosis 12 | 1,670
group 4 medulloblastoma 12 | 1,875
malignant mesothelioma 12 | 3,163
pituitary cancer 12 | 1,972
posterior fossa group A ependymoma 12 | 1,511
sonic hedgehog group medulloblastoma 12 | 1,482
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,289
subependymal giant cell astrocytoma 11 | 2,287
Osteoporosis 10 | 259
Rheumatoid Arthritis 10 | 1,170
adult high grade glioma 10 | 2,148
astrocytic glioma 10 | 2,241
colon cancer 10 | 1,475
pancreatic cancer 10 | 2,300
Pick disease 9 | 1,893
Prostatic Neoplasms 9 | 471
ulcerative colitis 9 | 2,087
acute myeloid leukemia 8 | 785
adrenocortical carcinoma 8 | 1,427
breast carcinoma 8 | 1,614
diabetes mellitus 8 | 1,663
ductal carcinoma in situ 8 | 1,745
spina bifida 8 | 1,064
Colonic Neoplasms 7 | 126
Colorectal Neoplasms 7 | 217
Liver carcinoma 7 | 217
Robinow syndrome 7 | 12
Stomach Neoplasms 7 | 282
atypical teratoid/rhabdoid tumor 7 | 1,095
primary pancreatic ductal adenocarcinoma 7 | 1,271
tuberculosis 7 | 1,563
Alzheimer's disease 6 | 644
Lung Neoplasms 6 | 171
Neoplastic Cell Transformation 6 | 81
Vascular disease 6 | 281
Waldenstrons macroglobulinemia 6 | 764
gastric carcinoma 6 | 832
nasopharyngeal carcinoma 6 | 1,056
posterior fossa group B ependymoma 6 | 1,530
Cleft palate 5 | 125
Crohn's disease 5 | 304
Familial adenomatous polyposis 5 | 33
Intellectual disability 5 | 573
Kidney disease 5 | 397
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse 5 | 12
Multiple myeloma 5 | 1,327
Obesity 5 | 616
Parkinson's disease 5 | 364
Schizophrenia 5 | 503
chronic lymphosyte leukemia 5 | 232
cutaneous lupus erythematosus 5 | 1,056
hepatocellular carcinoma 5 | 550
medulloblastoma 5 | 1,524
non primary Sjogren syndrome sicca 5 | 840
tuberculosis and treatment for 3 months 5 | 327
Actinic keratosis 4 | 22
Adenocarcinoma 4 | 115
Adenoma 4 | 165
Atopic dermatitis 4 | 944
Autistic Disorder 4 | 320
Cardiomegaly 4 | 66
Hemangiosarcoma 4 | 18
Hydrolethalus syndrome 4 | 128
Intestinal Neoplasms 4 | 11
Liver neoplasms 4 | 108
Mammary Neoplasms 4 | 410
Neoplasm Metastasis 4 | 138
Peripheral Neuropathy 4 | 303
Reperfusion Injury 4 | 84
Stomach cancer 4 | 18
acute quadriplegic myopathy 4 | 1,157
aldosterone-producing adenoma 4 | 664
chronic lymphocytic leukemia 4 | 244
esophageal adenocarcinoma 4 | 737
fibroadenoma 4 | 557
non diabetic and post-ischemic heart failure 4 | 200

Tissue

Digestive Tract 66 | 18,472
Endocrine System 66 | 18,511
Female tissues 66 | 18,646
Liver and Pancreas 66 | 18,135
Male tissues 66 | 17,968
Nervous System 66 | 18,560
Respiratory system 66 | 17,483
Skin and soft tissues 66 | 18,114
Urinary Tract 66 | 18,443
Blood and immune system 65 | 17,994
Cardiovascular System 65 | 17,957

Target Family

Non-IDG 31 | 11,969
Kinase 17 | 634
GPCR 9 | 408
Enzyme 6 | 4,146
Transcription Factor 3 | 1,400

WikiPathways Pathway

Wnt Signaling Pathway 66 | 66
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 257 | 257
Circadian rythm related genes 200 | 200
Integrated Pancreatic Cancer P... 192 | 192
Focal Adhesion 190 | 190
Metapathway biotransformation 172 | 172
MAPK Signaling Pathway 167 | 167
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
Myometrial Relaxation and Cont... 157 | 157
Sudden Infant Death Syndrome (... 157 | 157
Allograft Rejection 156 | 156
Integrated Breast Cancer Pathw... 152 | 152
Calcium Regulation in the Card... 150 | 150
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 128 | 128
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Signaling Pathways in Glioblas... 83 | 83
MicroRNAs in cardiomyocyte hyp... 82 | 82
Alzheimers Disease 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Arrhythmogenic Right Ventricul... 74 | 74
Peptide GPCRs 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
IL-1 signaling pathway 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Copper homeostasis 54 | 54
ErbB Signaling Pathway 54 | 54
IL-4 Signaling Pathway 54 | 54
Interferon type I signaling pa... 54 | 54
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54
Apoptosis-related network due ... 53 | 53
Cardiac Hypertrophic Response 53 | 53
Cardiac Progenitor Differentia... 53 | 53
Synaptic Vesicle Pathway 51 | 51
Translation Factors 51 | 51
Wnt Signaling Pathway Netpath 51 | 51

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -1.99707 87.2 90
Proto-oncogene Wnt-1 WNT1 Tbio Non-IDG -2.73870 492.7 294
Frizzled-1 FZD1 Tbio GPCR -2.04125 74.3 233
Low-density lipoprotein receptor LDLR Tchem Non-IDG -3.04462 893.1 512
Tyrosine-protein kinase transmembrane receptor ROR2 ROR2 Tbio Kinase -1.84344 79.9 342
Inactive tyrosine-protein kinase transmembrane receptor ROR1 ROR1 Tbio Kinase -1.29942 22.9 280
Myc proto-oncogene protein MYC Tbio Transcription Factor -4.09050 11730.8 2241
Mitogen-activated protein kinase 10 MAPK10 Tchem Kinase -2.27384 181.6 339
Protein kinase C iota type PRKCI Tchem Kinase -1.69816 51.8 122
Frizzled-10 FZD10 Tbio GPCR -1.33529 23.5 156