Development Level

Tbio 89 | 11,651
Tchem 35 | 1,388
Tclin 7 | 612
Tdark 4 | 6,593

Collection

RFA-RM-18-021 4 | 328
Kinase: IDG Consortium (Target... 3 | 125
Kinase: IDG Consortium (Comple... 2 | 37
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 14 | 979
preweaning lethality, incomple... 7 | 499
embryonic lethality prior to t... 6 | 278
abnormal heart morphology 5 | 162
enlarged heart 5 | 210
decreased total body fat amoun... 4 | 207
increased bone mineral content 4 | 108
decreased body length 3 | 101
decreased body weight 3 | 161
decreased vertical activity 3 | 208
increased or absent threshold ... 3 | 101
mammalian phenotype 3 | 17
small superior vagus ganglion 3 | 74
abnormal behavior 2 | 298
abnormal bone mineralization 2 | 38
abnormal bone structure 2 | 187
abnormal gait 2 | 69
abnormal snout morphology 2 | 23
abnormal tail movements 2 | 12
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased circulating insulin ... 2 | 76
decreased lean body mass 2 | 135
decreased startle reflex 2 | 75
embryonic lethality prior to o... 2 | 239
hydrometra 2 | 53
impaired glucose tolerance 2 | 75
increased blood urea nitrogen ... 2 | 48
increased bone mineral density 2 | 72
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased fasted circulating g... 2 | 76
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
kinked tail 2 | 2
male infertility 2 | 123
prenatal lethality prior to he... 2 | 87
abnormal body wall morphology 1 | 9
abnormal brain morphology 1 | 13
abnormal cranium morphology 1 | 36
abnormal embryo development 1 | 7
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal eyelid fusion 1 | 3
abnormal facial morphology 1 | 17
abnormal forelimb morphology 1 | 2
abnormal head morphology 1 | 10
abnormal head shape 1 | 10
abnormal iris morphology 1 | 13
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal limb morphology 1 | 13
abnormal locomotor behavior 1 | 24
abnormal maxilla morphology 1 | 17
abnormal pericardium morpholog... 1 | 26
abnormal retina morphology 1 | 71
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal vocalization 1 | 21
anophthalmia 1 | 33
cataract 1 | 92
corneal opacity 1 | 32
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased exploration in new e... 1 | 11
decreased heart left ventricle... 1 | 28
decreased prepulse inhibition 1 | 82
edema 1 | 59
hydroencephaly 1 | 14
hyperactivity 1 | 148
hypoactivity 1 | 132
increased B cell number 1 | 9
increased circulating LDL chol... 1 | 13
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased monocyte cell number 1 | 63
microphthalmia 1 | 26
polydactyly 1 | 7
prenatal lethality 1 | 28
protruding tongue 1 | 3
short tibia 1 | 97
small heart 1 | 10
syndactyly 1 | 23
thrombocytosis 1 | 27

Disease

Carcinoma 109 | 11,493
ovarian cancer 81 | 8,520
psoriasis 73 | 6,694
osteosarcoma 71 | 7,950
Cancer 62 | 2,499
atypical teratoid / rhabdoid tumor 61 | 5,112
glioblastoma 60 | 5,792
medulloblastoma, large-cell 60 | 6,241
ependymoma 59 | 4,679
group 3 medulloblastoma 46 | 4,104
lung cancer 46 | 4,740
Breast cancer 45 | 3,578
primitive neuroectodermal tumor 44 | 3,035
malignant mesothelioma 39 | 3,232
Astrocytoma, Pilocytic 38 | 3,081
adult high grade glioma 36 | 3,801
non-small cell lung cancer 34 | 2,890
oligodendroglioma 34 | 2,850
Kidney cancer 33 | 2,613
lung carcinoma 32 | 2,843
intraductal papillary-mucinous carcinoma (IPMC) 31 | 2,989
invasive ductal carcinoma 31 | 2,951
lung adenocarcinoma 31 | 2,716
astrocytic glioma 30 | 2,597
interstitial cystitis 30 | 2,312
Schizophrenia 29 | 1,160
intraductal papillary-mucinous adenoma (IPMA) 29 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,291
subependymal giant cell astrocytoma 27 | 2,287
diabetes mellitus 23 | 1,728
cystic fibrosis 22 | 1,696
pituitary cancer 22 | 1,972
pancreatic cancer 21 | 2,398
breast carcinoma 20 | 1,638
Intellectual disability 19 | 1,016
Pick disease 19 | 1,894
colon cancer 19 | 1,478
tuberculosis 19 | 2,010
ductal carcinoma in situ 18 | 1,745
Autosomal recessive predisposition 17 | 1,442
Bipolar Disorder 17 | 666
Osteoporosis 17 | 363
group 4 medulloblastoma 17 | 1,855
Rheumatoid arthritis 16 | 1,191
ulcerative colitis 16 | 1,819
Colorectal Neoplasms 15 | 243
Prostatic Neoplasms 15 | 495
Vascular disease 15 | 319
pediatric high grade glioma 15 | 1,064
Cognitive delay 14 | 608
Global developmental delay 14 | 608
Mental and motor retardation 14 | 608
Stomach Neoplasms 14 | 300
astrocytoma 13 | 1,146
primary pancreatic ductal adenocarcinoma 13 | 1,109
Colonic Neoplasms 12 | 142
Dull intelligence 12 | 645
Hypoplastic mandible condyle 12 | 275
Low intelligence 12 | 645
Mandibular hypoplasia 12 | 275
Mental Retardation 12 | 645
Mental deficiency 12 | 645
Micrognathism 12 | 275
Obesity 12 | 678
Orbital separation excessive 12 | 244
Parkinson's disease 12 | 392
Poor school performance 12 | 645
acute quadriplegic myopathy 12 | 1,158
adrenocortical carcinoma 12 | 1,428
cutaneous lupus erythematosus 12 | 1,057
medulloblastoma 12 | 720
Alzheimer's disease 11 | 658
Breast Neoplasms 11 | 445
Depressive disorder 11 | 409
Epilepsy 11 | 792
Kidney disease 11 | 430
Renal Cell Carcinoma 11 | 214
Short stature 11 | 531
acute myeloid leukemia 11 | 783
esophageal adenocarcinoma 11 | 737
gastric carcinoma 11 | 807
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
spina bifida 11 | 1,074
Adenoma 10 | 167
Atopic dermatitis 10 | 952
Carcinoma, Hepatocellular 10 | 228
Liver carcinoma 10 | 240
Mental Depression 10 | 333
non primary Sjogren syndrome sicca 10 | 891
Arthritis 9 | 290
Broad flat nasal bridge 9 | 236
Cleft Palate 9 | 271
Disease Models, Animal 9 | 155
Increased head circumference 9 | 147
Lung Neoplasms 9 | 232
Major Depressive Disorder 9 | 301
Melanoma 9 | 711
Multiple myeloma 9 | 1,332
Nasal bridge wide 9 | 236
fibroadenoma 9 | 559

Tissue

Digestive Tract 132 | 17,369
Endocrine System 132 | 18,159
Female tissues 131 | 17,400
Nervous System 131 | 16,725
Skin and soft tissues 131 | 17,230
Male tissues 130 | 17,142
Blood and immune system 129 | 16,909
Urinary Tract 128 | 16,678
Liver and Pancreas 127 | 16,750
Respiratory system 125 | 16,393
Cardiovascular System 118 | 15,192

Target Family

Non-IDG 62 | 12,091
Kinase 33 | 634
Transcription Factor 15 | 1,400
Enzyme 14 | 4,145
GPCR 9 | 408
Epigenetic 1 | 242
Nuclear Receptor 1 | 48

WikiPathways Pathway

Wnt Signaling Pathway 135 | 135
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 PLCB1 Tbio Enzyme -2.50444 332.8 190
Phosphatidylinositol 4-kinase type 2-alpha PI4K2A Tbio Kinase -2.88003 745.1 146
Wnt inhibitory factor 1 WIF1 Tbio Non-IDG -2.11284 143.2 350
Chromodomain-helicase-DNA-binding protein 8 CHD8 Tbio Epigenetic -1.64766 47.4 81
Tyrosine-protein kinase transmembrane receptor ROR2 ROR2 Tbio Kinase -1.88065 80.4 419
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.94674 87.1 452
Mitogen-activated protein kinase kinase kinase 7 MAP3K7 Tchem Kinase -1.46817 32.4 765
Cyclin-dependent kinase 6 CDK6 Tclin Kinase -2.71197 390.1 730
Dickkopf-related protein 1 DKK1 Tchem Non-IDG -2.79271 621.8 694
Vang-like protein 2 VANGL2 Tbio Non-IDG -2.29322 199.6 158