Development Level

Tbio 125 | 11,445
Tchem 39 | 1,598
Tdark 19 | 6,588
Tclin 13 | 613

Collection

GPCR: IDG Consortium (Complete... 1 | 25
Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

cataract 7 | 92
preweaning lethality, incomple... 7 | 499
abnormal lens morphology 5 | 81
decreased vertical activity 5 | 208
decreased circulating calcium ... 4 | 36
preweaning lethality, complete... 4 | 979
short tibia 3 | 97
abnormal behavior 2 | 298
abnormal bone structure 2 | 187
abnormal cranium morphology 2 | 36
abnormal epididymis morphology 2 | 42
abnormal lung morphology 2 | 26
abnormal seminal vesicle morph... 2 | 114
abnormal spleen morphology 2 | 55
abnormal testis morphology 2 | 43
decreased body weight 2 | 161
decreased circulating HDL chol... 2 | 68
decreased circulating choleste... 2 | 93
decreased circulating phosphat... 2 | 27
decreased threshold for audito... 2 | 26
decreased total body fat amoun... 2 | 207
embryonic lethality prior to o... 2 | 239
enlarged epididymis 2 | 31
enlarged heart 2 | 210
increased circulating alkaline... 2 | 122
increased mean corpuscular vol... 2 | 92
increased startle reflex 2 | 112
small testis 2 | 58
abnormal clavicle morphology 1 | 6
abnormal coat- hair morphology 1 | 19
abnormal coat-hair pigmentatio... 1 | 64
abnormal femur morphology 1 | 14
abnormal head morphology 1 | 10
abnormal humerus morphology 1 | 11
abnormal iris morphology 1 | 13
abnormal joint morphology 1 | 23
abnormal pelvic girdle bone mo... 1 | 12
abnormal radius morphology 1 | 8
abnormal retinal blood vessel ... 1 | 26
abnormal rib morphology 1 | 10
abnormal sleep behavior 1 | 70
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal urinary bladder morph... 1 | 11
abnormal vertebrae morphology 1 | 18
abnormal vibrissa morphology 1 | 25
abnormal vitreous body morphol... 1 | 10
absent vibrissae 1 | 12
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased cardiac muscle contr... 1 | 11
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased monocyte cell number 1 | 8
edema 1 | 59
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged adrenal glands 1 | 3
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
enlarged uterus 1 | 11
hydrometra 1 | 53
hyperactivity 1 | 148
hypoactivity 1 | 132
increased body length 1 | 32
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased prepulse inhibition 1 | 32
increased total body fat amoun... 1 | 134
irregularly shaped pupil 1 | 7
polycystic kidney 1 | 15
small heart 1 | 10
small kidney 1 | 16
small seminal vesicle 1 | 10
small spleen 1 | 19
thin ventricular wall 1 | 24
thrombocytosis 1 | 27
vertebral fusion 1 | 23

Disease

Carcinoma 112 | 11,493
psoriasis 110 | 6,694
ovarian cancer 89 | 8,520
Cancer 87 | 2,499
lung cancer 77 | 4,740
osteosarcoma 74 | 7,950
glioblastoma 69 | 5,792
medulloblastoma, large-cell 60 | 6,241
pancreatic cancer 57 | 2,398
diabetes mellitus 54 | 1,728
non-small cell lung cancer 52 | 2,890
intraductal papillary-mucinous adenoma (IPMA) 50 | 2,955
lung carcinoma 50 | 2,843
ulcerative colitis 50 | 1,819
Breast cancer 48 | 3,578
invasive ductal carcinoma 47 | 2,951
malignant mesothelioma 47 | 3,232
atypical teratoid / rhabdoid tumor 46 | 5,112
Astrocytoma, Pilocytic 45 | 3,081
interstitial cystitis 45 | 2,312
cystic fibrosis 44 | 1,696
lung adenocarcinoma 44 | 2,716
tuberculosis 42 | 2,010
intraductal papillary-mucinous carcinoma (IPMC) 41 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 41 | 3,291
Rheumatoid arthritis 40 | 1,191
ependymoma 40 | 4,679
adult high grade glioma 39 | 3,801
pituitary cancer 38 | 1,972
ductal carcinoma in situ 33 | 1,745
oligodendroglioma 32 | 2,850
adrenocortical carcinoma 31 | 1,428
group 3 medulloblastoma 31 | 4,104
breast carcinoma 28 | 1,638
subependymal giant cell astrocytoma 28 | 2,287
astrocytic glioma 27 | 2,597
cutaneous lupus erythematosus 26 | 1,057
pancreatic ductal adenocarcinoma liver metastasis 26 | 1,962
Atopic dermatitis 25 | 952
primary pancreatic ductal adenocarcinoma 25 | 1,109
Systemic lupus erythematosus 24 | 194
Multiple Sclerosis 22 | 540
Prostatic Neoplasms 22 | 495
active Crohn's disease 22 | 922
colon cancer 22 | 1,478
nasopharyngeal carcinoma 22 | 1,058
primitive neuroectodermal tumor 22 | 3,035
active ulcerative colitis 21 | 764
esophageal adenocarcinoma 21 | 737
Kidney disease 20 | 430
acute quadriplegic myopathy 20 | 1,158
astrocytoma 20 | 1,146
gastric carcinoma 20 | 807
group 4 medulloblastoma 20 | 1,855
sarcoidosis 20 | 370
Breast Neoplasms 19 | 445
Hypertension 19 | 396
Liver Cirrhosis, Experimental 19 | 769
Liver disease 19 | 237
Mammary Neoplasms 19 | 425
Asthma 18 | 385
Schizophrenia 18 | 1,160
juvenile dermatomyositis 18 | 1,187
mucosa-associated lymphoid tissue lymphoma 18 | 484
Duchenne muscular dystrophy 17 | 601
Hyperparathyroidism 17 | 48
Kidney cancer 17 | 2,613
Osteoporosis 17 | 363
Arthritis 16 | 290
Arthritis, Rheumatoid 16 | 174
Atherosclerosis 16 | 291
Obesity 16 | 678
autosomal dominant Emery-Dreifuss muscular dystrophy 16 | 510
medulloblastoma 16 | 720
Bipolar Disorder 15 | 666
Hypercalcemia 15 | 59
Narcolepsy 15 | 72
dermatomyositis 15 | 966
fibroadenoma 15 | 559
pediatric high grade glioma 15 | 1,064
Berylliosis 14 | 28
Diffuse cutaneous systemic sclerosis 14 | 17
Melanoma 14 | 711
Narcolepsy-cataplexy 14 | 21
Stomach Neoplasms 14 | 300
Vascular disease 14 | 319
follicular lymphoma 14 | 20
limited scleroderma 14 | 19
spina bifida 14 | 1,074
Coronary artery disease 13 | 268
Crohn's disease 13 | 321
Down syndrome 13 | 499
Hypersensitivity reaction type II disease 13 | 253
Multiple Sclerosis, Susceptibility to 13 | 15
Pick disease 13 | 1,894
Rheumatoid Arthritis, Systemic Juvenile 13 | 16
Sarcoidosis 1 13 | 14
gastric cancer 13 | 459
primary Sjogren syndrome 13 | 735
Lung Neoplasms 12 | 232

Tissue

Female tissues 171 | 17,400
Digestive Tract 170 | 17,369
Skin and soft tissues 168 | 17,230
Liver and Pancreas 166 | 16,750
Endocrine System 165 | 18,159
Blood and immune system 163 | 16,909
Male tissues 163 | 17,142
Urinary Tract 161 | 16,678
Respiratory system 155 | 16,393
Nervous System 153 | 16,725
Cardiovascular System 135 | 15,192

Target Family

Non-IDG 117 | 12,091
Enzyme 37 | 4,145
Transcription Factor 19 | 1,400
Transporter 9 | 473
GPCR 5 | 408
Kinase 3 | 634
Nuclear Receptor 3 | 48
Ion Channel 2 | 344
TF/Epigenetic 1 | 38

WikiPathways Pathway

Vitamin D Receptor Pathway 196 | 196
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Caspase-14 CASP14 Tchem Enzyme -1.81937 73.7 348
Hypoxia-inducible lipid droplet-associated protein HILPDA Tbio Non-IDG -1.24205 21.6 18
Sal-like protein 4 SALL4 Tbio Transcription Factor -2.64737 454.3 165
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 ASAP2 Tbio Non-IDG -1.14527 15.1 71
Interferon regulatory factor 5 IRF5 Tbio Transcription Factor -2.33923 241.0 400
Ephrin type-B receptor 4 EPHB4 Tchem Kinase -2.26622 206.3 514
Leukocyte elastase inhibitor SERPINB1 Tbio Enzyme -2.55345 336.3 370
Homeobox protein CDX-2 CDX2 Tbio Transcription Factor -2.91273 837.0 699
Zinc finger protein 257 ZNF257 Tdark Transcription Factor -0.06695 1.13 37
Interleukin-1 receptor-like 1 IL1RL1 Tbio Non-IDG -2.06895 107.0 347