Development Level

Tchem 5 | 1,598
Tclin 3 | 613
Tbio 2 | 11,445

IMPC Phenotype

abnormal heart morphology 2 | 162
decreased circulating HDL chol... 2 | 68
decreased circulating calcium ... 2 | 36
decreased circulating choleste... 2 | 93
decreased circulating glucose ... 2 | 126
decreased total body fat amoun... 2 | 207
enlarged heart 2 | 210
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal clavicle morphology 1 | 6
abnormal cranium morphology 1 | 36
abnormal femur morphology 1 | 14
abnormal fibula morphology 1 | 2
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 23
abnormal pelvic girdle bone mo... 1 | 12
abnormal radius morphology 1 | 8
abnormal rib morphology 1 | 10
abnormal scapula morphology 1 | 3
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 18
absent mammary gland 1 | 1
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating phosphat... 1 | 27
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
decreased skeletal muscle mass 1 | 1
decreased vertical activity 1 | 208
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
short tibia 1 | 97
small heart 1 | 10
small kidney 1 | 16
small ovary 1 | 1
small spleen 1 | 19
small uterus 1 | 3
thin skin 1 | 2

Disease

Carcinoma 8 | 11,493
Cancer 7 | 2,499
Rickets 6 | 49
Autosomal recessive predisposition 5 | 1,442
Hyperparathyroidism 5 | 48
Osteomalacia 5 | 35
Osteoporosis 5 | 363
malignant mesothelioma 5 | 3,232
osteosarcoma 5 | 7,950
psoriasis 5 | 6,694
Bone Diseases, Metabolic 4 | 14
Failure to gain weight 4 | 365
Hypercalcemia 4 | 59
Hypophosphatemia 4 | 40
Kidney disease 4 | 430
Liver Cirrhosis 4 | 181
Metabolic Bone Disorder 4 | 11
Multiple Sclerosis 4 | 540
Muscle hypotonia 4 | 571
Pediatric failure to thrive 4 | 365
invasive ductal carcinoma 4 | 2,951
lung carcinoma 4 | 2,843
non-small cell lung cancer 4 | 2,890
ovarian cancer 4 | 8,520
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
Breast Neoplasms 3 | 445
Cataract 3 | 297
Dull intelligence 3 | 645
Epilepsy 3 | 792
Hyperparathyroidism, Secondary 3 | 7
Hyperphosphatemia 3 | 32
Hypertension 3 | 396
Hypervitaminosis D 3 | 8
Hypocalcemia 3 | 32
Hypoparathyroidism 3 | 41
Intellectual disability 3 | 1,016
Lens Opacities 3 | 231
Low intelligence 3 | 645
Mammary Neoplasms 3 | 425
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Poor school performance 3 | 645
Seizures 3 | 596
diabetes mellitus 3 | 1,728
group 4 medulloblastoma 3 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
lung adenocarcinoma 3 | 2,716
lung cancer 3 | 4,740
nephrosclerosis 3 | 333
Alkaline phosphatase serum increased 2 | 29
Alopecia 2 | 115
Arthritis 2 | 290
Atherosclerosis 2 | 291
Atopic dermatitis 2 | 952
Bone pain 2 | 42
Calcinosis 2 | 70
Defective enamel matrix 2 | 35
Delayed epiphyseal ossification 2 | 10
Delayed maturation of end part of long bone 2 | 10
Dental Enamel Hypoplasia 2 | 43
Difficulty walking 2 | 28
Dysplasia of tooth enamel 2 | 35
Femoral bowing 2 | 20
Flat back of the head 2 | 26
Flat occiput 2 | 26
Frequent fractures 2 | 53
Frontal bossing 2 | 157
Genu varum 2 | 29
Growth delay 2 | 114
Growth failure 2 | 114
Growth retardation 2 | 115
Hypercalciuria 2 | 27
Hypersensitivity reaction type II disease 2 | 253
Increased fracture rate 2 | 53
Increased serum parathyroid hormone 2 | 14
Irritation - emotion 2 | 68
Late tooth eruption 2 | 61
Liver disease 2 | 237
Lung Neoplasms 2 | 232
Metaphyseal irregularity 2 | 23
Motor delay 2 | 147
Nephrolithiasis 2 | 56
No development of motor milestones 2 | 147
Plaque psoriasis 2 | 17
Poor growth 2 | 114
Primary cutaneous T-cell lymphoma 2 | 29
Prostatic Neoplasms 2 | 495
Schizophrenia 2 | 1,160
Thin bony cortex 2 | 9
Thin dental enamel 2 | 35
Uremia 2 | 19
Varying degree of multiple fractures 2 | 53
Very poor growth 2 | 114
Vomiting 2 | 116
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
nutritional deficiency disease 2 | 9
pancreatic cancer 2 | 2,398
pituitary cancer 2 | 1,972
subependymal giant cell astrocytoma 2 | 2,287

Tissue

Digestive Tract 10 | 17,369
Endocrine System 10 | 18,159
Liver and Pancreas 10 | 16,750
Male tissues 10 | 17,142
Skin and soft tissues 10 | 17,230
Blood and immune system 9 | 16,909
Female tissues 9 | 17,400
Nervous System 9 | 16,725
Respiratory system 9 | 16,393
Urinary Tract 9 | 16,678
Cardiovascular System 7 | 15,192

Target Family

Enzyme 5 | 4,145
Nuclear Receptor 3 | 48
Non-IDG 2 | 12,091

WikiPathways Pathway

Vitamin D Metabolism 10 | 10
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Retinoic acid receptor RXR-beta RXRB Tclin Nuclear Receptor -1.72557 49.3 274
Vitamin D 25-hydroxylase CYP2R1 Tbio Enzyme -1.96830 95.4 152
7-dehydrocholesterol reductase DHCR7 Tchem Enzyme -2.44252 276.5 109
Vitamin D3 receptor VDR Tclin Nuclear Receptor -3.62166 3805.7 575
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial CYP24A1 Tchem Enzyme -2.91460 825.9 228
Vitamin D-binding protein GC Tchem Non-IDG -3.07485 1140.6 428
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 Tchem Enzyme -2.70628 492.9 68
Parathyroid hormone PTH Tbio Non-IDG -4.31704 21156.6 1312
Sterol 26-hydroxylase, mitochondrial CYP27A1 Tchem Enzyme -2.99010 980.2 164
Retinoic acid receptor RXR-alpha RXRA Tclin Nuclear Receptor -2.48285 237.9 299