Development Level

Tbio 8 | 11,445
Tchem 3 | 1,598
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal lens morphology 1 | 81
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased hemoglobin content 1 | 45
thin ventricular wall 1 | 24

Disease

Carcinoma 12 | 11,493
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
Cognitive delay 6 | 608
Global developmental delay 6 | 608
Mental and motor retardation 6 | 608
ovarian cancer 6 | 8,520
Autosomal recessive predisposition 5 | 1,442
Epilepsy 5 | 792
Muscle hypotonia 5 | 571
atypical teratoid / rhabdoid tumor 5 | 5,112
lung cancer 5 | 4,740
osteosarcoma 5 | 7,950
ulcerative colitis 5 | 1,819
Cancer 4 | 2,499
Chemical and Drug Induced Liver Injury 4 | 195
Liver disease 4 | 237
Seizures 4 | 596
glioblastoma 4 | 5,792
medulloblastoma, large-cell 4 | 6,241
psoriasis 4 | 6,694
Acidosis, Lactic 3 | 97
Breast cancer 3 | 3,578
Hypoglycemia 3 | 152
Lactic acidemia 3 | 95
Lethargy 3 | 77
Metabolic acidosis 3 | 90
Multiple myeloma 3 | 1,332
Schizophrenia 3 | 1,160
adult high grade glioma 3 | 3,801
colon cancer 3 | 1,478
ependymoma 3 | 4,679
group 4 medulloblastoma 3 | 1,855
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
lung carcinoma 3 | 2,843
malignant mesothelioma 3 | 3,232
nephrosclerosis 3 | 333
non primary Sjogren syndrome sicca 3 | 891
Abnormal amniotic fluid 2 | 6
Abnormality of blood and blood-forming tissues 2 | 10
Abnormality of metabolism/homeostasis 2 | 134
Abnormality of the haematopoietic system 2 | 10
Acquired immunodeficiency syndrome 2 | 197
Astrocytoma, Pilocytic 2 | 3,081
Autistic Disorder 2 | 364
Cardiomyopathies 2 | 110
Cardiomyopathy 2 | 116
Cardiomyopathy, Dilated 2 | 83
Cholestasis 2 | 155
Congestive heart failure 2 | 113
Elevated hepatic transaminases 2 | 81
Failure to gain weight 2 | 365
Generalized muscle weakness 2 | 57
Heart Diseases 2 | 43
Heart failure 2 | 162
Hematological Disease 2 | 18
Hepatic enzyme increased 2 | 81
Hydrops Fetalis 2 | 21
Hyperammonemia 2 | 30
Hyperreflexia 2 | 209
Hypoketotic hypoglycemia 2 | 11
Infantile onset 2 | 238
Isovaleric acidemia 2 | 15
Liver Cirrhosis, Experimental 2 | 769
Liver Dysfunction 2 | 99
Liver enzymes abnormal 2 | 81
Liver function test increased 2 | 81
Liver function tests abnormal finding 2 | 81
Low Birth Weights 2 | 69
Lung Neoplasms 2 | 232
Major Depressive Disorder 2 | 301
Medium chain acyl-CoA dehydrogenase deficiency 2 | 13
Motor delay 2 | 147
Myoglobinuria 2 | 15
Neuropathy 2 | 261
Nicotine dependence 2 | 54
No development of motor milestones 2 | 147
Osteoarthritis 2 | 184
Pediatric failure to thrive 2 | 365
Peripheral Neuropathy 2 | 134
Pick disease 2 | 1,894
Psychotic Disorders 2 | 151
Respiratory Failure 2 | 104
Rhabdomyolysis 2 | 15
Small for gestational age (disorder) 2 | 69
Subclinical abnormal liver function tests 2 | 81
Transaminases increased 2 | 81
Unipolar Depression 2 | 250
Very long chain acyl-CoA dehydrogenase deficiency 2 | 10
Waldenstrons macroglobulinemia 2 | 765
astrocytoma 2 | 1,146
beta-ketothiolase deficiency 2 | 13
chronic rhinosinusitis 2 | 512
cystic fibrosis 2 | 1,696
oligodendroglioma 2 | 2,850
pancreatic cancer 2 | 2,398
primitive neuroectodermal tumor 2 | 3,035
subependymal giant cell astrocytoma 2 | 2,287

Tissue

Liver and Pancreas 13 | 16,750
Skin and soft tissues 13 | 17,230
Urinary Tract 13 | 16,678
Digestive Tract 12 | 17,369
Female tissues 12 | 17,400
Male tissues 12 | 17,142
Respiratory system 12 | 16,393
Blood and immune system 11 | 16,909
Endocrine System 11 | 18,159
Cardiovascular System 10 | 15,192
Nervous System 10 | 16,725

Target Family

Enzyme 7 | 4,145
Non-IDG 5 | 12,091
Epigenetic 1 | 242

WikiPathways Pathway

Valproic acid pathway 13 | 13
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Isovaleryl-CoA dehydrogenase, mitochondrial IVD Tbio Enzyme -3.13592 1365.7 103
Acyl-coenzyme A synthetase ACSM1, mitochondrial ACSM1 Tbio Enzyme -2.32216 206.5 61
Peroxisomal bifunctional enzyme EHHADH Tbio Non-IDG -2.05616 109.3 204
UDP-glucuronosyltransferase 1-3 UGT1A3 Tbio Enzyme -1.83933 63.3 13
3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 Tbio Enzyme -2.13468 132.4 359
Histone deacetylase 1 HDAC1 Tclin Epigenetic -3.03775 954.3 1201
Trifunctional enzyme subunit alpha, mitochondrial HADHA Tbio Non-IDG -2.99704 989.4 151
4-aminobutyrate aminotransferase, mitochondrial ABAT Tclin Enzyme -2.02391 104.3 204
Cytochrome P450 2C9 CYP2C9 Tchem Non-IDG -3.21210 1623.8 177
Cytochrome P450 2A6 CYP2A6 Tchem Non-IDG -2.84002 705.5 272