Development Level

Tbio 119 | 11,651
Tchem 91 | 1,388
Tclin 25 | 612

Collection

Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 21 | 979
preweaning lethality, incomple... 7 | 499
abnormal bone structure 6 | 187
abnormal embryo size 6 | 220
decreased bone mineral content 6 | 151
embryonic lethality prior to t... 6 | 278
abnormal behavior 5 | 298
enlarged heart 5 | 210
abnormal retina morphology 4 | 71
decreased bone mineral density 4 | 126
decreased total body fat amoun... 4 | 207
enlarged spleen 4 | 41
hypoactivity 4 | 132
increased circulating HDL chol... 4 | 80
increased circulating alkaline... 4 | 122
male infertility 4 | 123
abnormal gait 3 | 69
abnormal neural tube closure 3 | 46
decreased body weight 3 | 161
decreased circulating creatini... 3 | 39
decreased mean corpuscular vol... 3 | 79
embryonic growth retardation 3 | 106
increased neutrophil cell numb... 3 | 46
short tibia 3 | 97
thrombocytopenia 3 | 56
tremors 3 | 39
abnormal cornea morphology 2 | 31
abnormal forebrain development 2 | 20
abnormal hindbrain development 2 | 16
abnormal lens morphology 2 | 81
abnormal midbrain development 2 | 20
abnormal sleep behavior 2 | 70
anophthalmia 2 | 33
cataract 2 | 92
decreased blood urea nitrogen ... 2 | 51
decreased circulating amylase ... 2 | 28
decreased circulating sodium l... 2 | 22
decreased circulating triglyce... 2 | 79
decreased fasted circulating g... 2 | 65
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular hem... 2 | 50
decreased neutrophil cell numb... 2 | 42
embryonic lethality prior to o... 2 | 239
enlarged kidney 2 | 14
hyperactivity 2 | 148
improved glucose tolerance 2 | 79
increased circulating LDL chol... 2 | 13
increased circulating calcium ... 2 | 34
increased circulating choleste... 2 | 66
increased circulating iron lev... 2 | 30
increased circulating phosphat... 2 | 26
increased circulating triglyce... 2 | 42
increased erythrocyte cell num... 2 | 39
increased hemoglobin content 2 | 45
increased leukocyte cell numbe... 2 | 47
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
prenatal lethality prior to he... 2 | 87
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal head morphology 1 | 10
abnormal optic disc morphology 1 | 10
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
abnormal whole-body plethysmog... 1 | 4
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating bilirubi... 1 | 19
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased red blood cell distr... 1 | 41
decreased total retina thickne... 1 | 17
enlarged lymph nodes 1 | 37
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral density 1 | 72
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating potassiu... 1 | 29
increased eosinophil cell numb... 1 | 11
increased heart weight 1 | 62
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
persistence of hyaloid vascula... 1 | 33
small superior vagus ganglion 1 | 74
thin ventricular wall 1 | 24

Disease

Carcinoma 178 | 11,493
ovarian cancer 159 | 8,520
Cancer 156 | 2,499
glioblastoma 136 | 5,792
osteosarcoma 136 | 7,950
lung cancer 117 | 4,740
medulloblastoma, large-cell 111 | 6,241
psoriasis 108 | 6,694
atypical teratoid / rhabdoid tumor 101 | 5,112
ependymoma 95 | 4,679
Breast cancer 85 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 74 | 3,291
adult high grade glioma 72 | 3,801
non-small cell lung cancer 72 | 2,890
pancreatic cancer 65 | 2,398
oligodendroglioma 64 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 63 | 2,989
lung adenocarcinoma 63 | 2,716
invasive ductal carcinoma 62 | 2,951
malignant mesothelioma 61 | 3,232
Astrocytoma, Pilocytic 59 | 3,081
Schizophrenia 59 | 1,160
diabetes mellitus 59 | 1,728
primitive neuroectodermal tumor 59 | 3,035
Kidney cancer 58 | 2,613
group 3 medulloblastoma 57 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 55 | 2,955
tuberculosis 54 | 2,010
lung carcinoma 53 | 2,843
cystic fibrosis 50 | 1,696
group 4 medulloblastoma 50 | 1,855
interstitial cystitis 50 | 2,312
Rheumatoid arthritis 47 | 1,191
subependymal giant cell astrocytoma 47 | 2,287
ulcerative colitis 46 | 1,819
astrocytic glioma 43 | 2,597
pituitary cancer 43 | 1,972
Breast Neoplasms 40 | 445
Vascular disease 40 | 319
Mammary Neoplasms 39 | 425
Multiple myeloma 39 | 1,332
astrocytoma 38 | 1,146
juvenile dermatomyositis 37 | 1,187
Pick disease 36 | 1,894
breast carcinoma 36 | 1,638
Hypertension 34 | 396
pediatric high grade glioma 34 | 1,064
primary pancreatic ductal adenocarcinoma 34 | 1,109
colon cancer 33 | 1,478
pancreatic ductal adenocarcinoma liver metastasis 33 | 1,962
ductal carcinoma in situ 31 | 1,745
acute quadriplegic myopathy 30 | 1,158
Kidney disease 29 | 430
Prostatic Neoplasms 29 | 495
dermatomyositis 29 | 966
Arthritis 28 | 290
Bipolar Disorder 28 | 666
Liver Cirrhosis, Experimental 28 | 769
Neoplasm Metastasis 28 | 168
Stomach Neoplasms 28 | 300
Obesity 27 | 678
adrenocortical carcinoma 27 | 1,428
Alzheimer's disease 26 | 658
Heart disease 26 | 306
Depressive disorder 24 | 409
nasopharyngeal carcinoma 24 | 1,058
spina bifida 24 | 1,074
Asthma 23 | 385
Autosomal recessive predisposition 23 | 1,442
Neoplasm Invasiveness 22 | 161
Atherosclerosis 21 | 291
Hypertensive disease 21 | 292
Liver carcinoma 21 | 240
Osteoporosis 21 | 363
Reperfusion Injury 21 | 86
pancreatic carcinoma 21 | 562
Carcinoma, Hepatocellular 20 | 228
Carcinoma, Squamous Cell 20 | 110
Multiple Sclerosis 20 | 540
Myocardial Ischemia 20 | 169
Waldenstrons macroglobulinemia 20 | 765
gastric carcinoma 20 | 807
Endometriosis 19 | 540
Intellectual disability 19 | 1,016
Lung Neoplasms 19 | 232
Lung disease 19 | 142
Mental Depression 19 | 333
Muscle hypotonia 19 | 571
Squamous cell carcinoma 19 | 129
Adenocarcinoma 18 | 122
Brain Ischemia 18 | 110
Colorectal Neoplasms 18 | 243
Down syndrome 18 | 499
Renal Cell Carcinoma 18 | 214
Short stature 18 | 531
aldosterone-producing adenoma 18 | 665
Atopic dermatitis 17 | 952
Cerebrovascular disease 17 | 238
Major Depressive Disorder 17 | 301
Orbital separation excessive 17 | 244

Tissue

Digestive Tract 234 | 17,369
Endocrine System 234 | 18,159
Female tissues 234 | 17,400
Liver and Pancreas 234 | 16,750
Blood and immune system 233 | 16,909
Male tissues 233 | 17,142
Skin and soft tissues 233 | 17,230
Urinary Tract 233 | 16,678
Respiratory system 232 | 16,393
Cardiovascular System 230 | 15,192
Nervous System 230 | 16,725

Target Family

Non-IDG 104 | 12,091
Kinase 52 | 634
Enzyme 42 | 4,145
Transcription Factor 23 | 1,400
Epigenetic 6 | 242
Ion Channel 3 | 344
Nuclear Receptor 3 | 48
GPCR 1 | 408
Transporter 1 | 473

WikiPathways Pathway

VEGFA-VEGFR2 Signaling Pathway 235 | 235
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Epsin-1 EPN1 Tbio Non-IDG -1.52389 32.5 163
E-selectin SELE Tchem Non-IDG -3.44926 2672.1 919
Cyclic AMP-dependent transcription factor ATF-2 ATF2 Tbio Transcription Factor -2.23104 170.7 1819
Ezrin EZR Tbio Non-IDG -2.99865 981.3 1088
F-box/WD repeat-containing protein 11 FBXW11 Tbio Non-IDG -0.75887 5.88 183
5'-AMP-activated protein kinase catalytic subunit alpha-2 PRKAA2 Tchem Kinase -1.42705 21.1 603
Calpain-2 catalytic subunit CAPN2 Tchem Non-IDG -1.69585 48.5 220
Cytoplasmic protein NCK1 NCK1 Tbio Non-IDG -2.25032 186.5 398