Development Level

Tbio 12 | 11,651
Tchem 6 | 1,388
Tclin 2 | 612

IMPC Phenotype

decreased body length 2 | 101
preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating bilirubi... 1 | 19
decreased circulating glucose ... 1 | 126
decreased circulating phosphat... 1 | 27
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased food intake 1 | 13
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating potassiu... 1 | 29
male infertility 1 | 123
thin ventricular wall 1 | 24
thrombocytopenia 1 | 56

Disease

psoriasis 12 | 6,694
Carcinoma 11 | 11,493
Dull intelligence 11 | 645
Intellectual disability 11 | 1,016
Low intelligence 11 | 645
Mental Retardation 11 | 645
Mental deficiency 11 | 645
Poor school performance 11 | 645
medulloblastoma, large-cell 11 | 6,241
Autosomal recessive predisposition 10 | 1,442
Cognitive delay 10 | 608
Global developmental delay 10 | 608
Mental and motor retardation 10 | 608
Epilepsy 9 | 792
Seizures 9 | 596
lung cancer 9 | 4,740
ovarian cancer 9 | 8,520
lung adenocarcinoma 8 | 2,716
Failure to gain weight 7 | 365
Hyperammonemia 7 | 30
Pediatric failure to thrive 7 | 365
adult high grade glioma 7 | 3,801
atypical teratoid / rhabdoid tumor 7 | 5,112
osteosarcoma 7 | 7,950
Breast cancer 6 | 3,578
Vomiting 6 | 116
group 3 medulloblastoma 6 | 4,104
Argininosuccinic aciduria 5 | 17
Irritation - emotion 5 | 68
Muscle hypotonia 5 | 571
glioblastoma 5 | 5,792
invasive ductal carcinoma 5 | 2,951
Alkalosis, Respiratory 4 | 5
Brain Edema 4 | 50
Cancer 4 | 2,499
Cerebellar Ataxia 4 | 304
Cerebral Edema 4 | 30
Citrullinemia 4 | 14
Comatose 4 | 56
Episodic ammonia intoxication 4 | 4
Gyrate atrophy 4 | 7
Hyperargininemia 4 | 8
Lethargy 4 | 77
Liver Cirrhosis, Experimental 4 | 769
Orbital separation excessive 4 | 244
Orotic aciduria 4 | 18
Protein avoidance 4 | 5
ependymoma 4 | 4,679
interstitial cystitis 4 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
non-small cell lung cancer 4 | 2,890
pancreatic cancer 4 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
pituitary cancer 4 | 1,972
primitive neuroectodermal tumor 4 | 3,035
AGAT deficiency 3 | 6
Abnormal urinary amino-acid findings 3 | 38
Adenocarcinoma of lung 3 | 142
Aminoaciduria 3 | 38
Arginine deficiency 3 | 3
Astrocytoma, Pilocytic 3 | 3,081
Cutis Laxa 3 | 39
Delayed speech and language development 3 | 112
Disease Models, Animal 3 | 155
Fetal Growth Retardation 3 | 189
High plasma glutamine 3 | 3
Highly variable clinical phenotype 3 | 150
Highly variable phenotype and severity 3 | 150
Highly variable phenotype, even within families 3 | 150
Hypoargininemia 3 | 3
Kidney cancer 3 | 2,613
Language Delay 3 | 112
Leishmaniasis 3 | 47
Myopathy 3 | 185
Ornithine carbamoyltransferase deficiency 3 | 12
Ornithine translocase deficiency 3 | 7
Phenotypic variability 3 | 150
Precancerous Conditions 3 | 80
Short stature 3 | 531
Speech Delay 3 | 112
Speech impairment 3 | 112
Tyrosinemia type II 3 | 7
active ulcerative colitis 3 | 764
cutaneous lupus erythematosus 3 | 1,057
dermatomyositis 3 | 966
esophageal adenocarcinoma 3 | 737
fibroadenoma 3 | 559
nephrosclerosis 3 | 333
oligodendroglioma 3 | 2,850
ulcerative colitis 3 | 1,819
Acquired scoliosis 2 | 281
Colonic Neoplasms 2 | 142
Generalized elastolysis 2 | 24
Hanging skin 2 | 24
Hypoglycemia 2 | 152
Kidney disease 2 | 430
Pectus excavatum 2 | 100
active Crohn's disease 2 | 922

Tissue

Blood and immune system 20 | 16,909
Digestive Tract 20 | 17,369
Endocrine System 20 | 18,159
Female tissues 20 | 17,400
Liver and Pancreas 20 | 16,750
Nervous System 20 | 16,725
Skin and soft tissues 20 | 17,230
Urinary Tract 20 | 16,678
Cardiovascular System 19 | 15,192
Male tissues 19 | 17,142
Respiratory system 19 | 16,393

Target Family

Enzyme 18 | 4,145
Kinase 2 | 634

WikiPathways Pathway

Urea cycle and metabolism of a... 20 | 20
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Delta-1-pyrroline-5-carboxylate synthase ALDH18A1 Tbio Enzyme -2.34260 216.5 146
Creatine kinase B-type CKB Tbio Kinase -2.09121 122.4 465
Argininosuccinate synthase ASS1 Tbio Enzyme -2.30801 186.1 322
Ornithine carbamoyltransferase, mitochondrial OTC Tchem Enzyme -2.21752 151.7 480
Aminoacylase-1 ACY1 Tbio Enzyme -2.00409 100.3 313
Ornithine decarboxylase ODC1 Tclin Enzyme -3.37636 2514.9 440
Glutamate dehydrogenase 1, mitochondrial GLUD1 Tbio Enzyme -2.39787 257.7 148
Argininosuccinate lyase ASL Tbio Enzyme -2.13476 130.8 199
Arginase-2, mitochondrial ARG2 Tchem Enzyme -2.46702 275.2 245
Glycine amidinotransferase, mitochondrial GATM Tbio Enzyme -2.34742 219.1 219