Development Level

Tbio 12 | 11,651
Tchem 5 | 1,388
Tclin 5 | 612

IMPC Phenotype

preweaning lethality, complete... 3 | 979
impaired glucose tolerance 2 | 75
abnormal behavior 1 | 298
cardiovascular system phenotyp... 1 | 36
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 38
decreased fasted circulating g... 1 | 65
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
increased circulating LDL chol... 1 | 13
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating iron lev... 1 | 30
increased mean corpuscular hem... 1 | 96
preweaning lethality, incomple... 1 | 499
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36

Disease

Carcinoma 16 | 11,493
Cancer 12 | 2,499
diabetes mellitus 12 | 1,728
Hyperglycemia 11 | 137
osteosarcoma 10 | 7,950
psoriasis 10 | 6,694
Obesity 9 | 678
ovarian cancer 9 | 8,520
Autosomal recessive predisposition 8 | 1,442
Diabetes Mellitus, Experimental 8 | 108
Diabetes Mellitus, Non-Insulin-Dependent 8 | 145
Cognitive delay 7 | 608
Diabetes Mellitus, Type 2 7 | 142
Global developmental delay 7 | 608
Hyperinsulinism 7 | 133
Hypertension 7 | 396
Hypoglycemia 7 | 152
Mental and motor retardation 7 | 608
atypical teratoid / rhabdoid tumor 7 | 5,112
glioblastoma 7 | 5,792
Alzheimer's disease 6 | 658
Epilepsy 6 | 792
Insulin Resistance 6 | 72
Intellectual disability 6 | 1,016
Neuropathy 6 | 261
ependymoma 6 | 4,679
medulloblastoma, large-cell 6 | 6,241
Astrocytoma, Pilocytic 5 | 3,081
Breast cancer 5 | 3,578
Diabetes Mellitus, Noninsulin-Dependent 5 | 31
Failure to gain weight 5 | 365
Hyperalgesia 5 | 83
Pediatric failure to thrive 5 | 365
Polycystic ovary syndrome 5 | 360
Schizophrenia 5 | 1,160
Seizures 5 | 596
adult high grade glioma 5 | 3,801
group 3 medulloblastoma 5 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
Arthritis 4 | 290
Bipolar Disorder 4 | 666
Carcinoma, Hepatocellular 4 | 228
Dull intelligence 4 | 645
Fatty liver disease 4 | 103
Fetal Growth Retardation 4 | 189
Heart disease 4 | 306
Hypertensive disease 4 | 292
Infant, Small for Gestational Age 4 | 176
Intrauterine retardation 4 | 176
Kidney cancer 4 | 2,613
Kidney disease 4 | 430
Lipid metabolism disorder 4 | 114
Liver Cirrhosis, Experimental 4 | 769
Liver carcinoma 4 | 240
Low Birth Weights 4 | 69
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Neurodegenerative disease 4 | 414
Osteoporosis 4 | 363
Parkinson's disease 4 | 392
Poor school performance 4 | 645
Small for gestational age (disorder) 4 | 69
Vascular disease 4 | 319
interstitial cystitis 4 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
invasive ductal carcinoma 4 | 2,951
oligodendroglioma 4 | 2,850
spina bifida 4 | 1,074
Alzheimer Disease 3 | 83
Anemia 3 | 365
Blepharoptosis 3 | 231
Comatose 3 | 56
Coronary artery disease 3 | 268
Diarrhea 3 | 253
Disease Models, Animal 3 | 155
Dysarthria 3 | 192
Hepatomegaly 3 | 285
Infantile onset 3 | 238
Liver disease 3 | 237
Motor delay 3 | 147
Muscle Weakness 3 | 170
Myocardial Ischemia 3 | 169
No development of motor milestones 3 | 147
Progressive disorder 3 | 142
Retinal Diseases 3 | 55
Rheumatoid arthritis 3 | 1,191
Stomach Neoplasms 3 | 300
Toxic encephalopathy 3 | 141
Type 2 diabetes mellitus 3 | 272
Weight decreased 3 | 103
acute myeloid leukemia 3 | 783
dermatomyositis 3 | 966
ductal carcinoma in situ 3 | 1,745
lung cancer 3 | 4,740
lung carcinoma 3 | 2,843
primitive neuroectodermal tumor 3 | 3,035
subependymal giant cell astrocytoma 3 | 2,287
tuberculosis 3 | 2,010

Tissue

Liver and Pancreas 22 | 16,750
Digestive Tract 21 | 17,369
Endocrine System 21 | 18,159
Female tissues 20 | 17,400
Nervous System 20 | 16,725
Skin and soft tissues 20 | 17,230
Urinary Tract 20 | 16,678
Male tissues 19 | 17,142
Blood and immune system 18 | 16,909
Respiratory system 18 | 16,393
Cardiovascular System 17 | 15,192

Target Family

Kinase 9 | 634
Non-IDG 6 | 12,091
Ion Channel 2 | 344
Transcription Factor 2 | 1,400
Transporter 2 | 473
Enzyme 1 | 4,145

WikiPathways Pathway

Type II diabetes mellitus 22 | 22
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Phosphoinositide 3-kinase regulatory subunit 5 PIK3R5 Tbio Enzyme -1.52582 28.6 325
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.18822 1239.4 1248
Solute carrier family 2, facilitated glucose transporter member 4 SLC2A4 Tbio Transporter -3.33806 2184.5 526
Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 Tchem Transporter -2.81915 616.6 291
Insulin receptor substrate 1 IRS1 Tbio Non-IDG -3.18611 1482.3 1920
Glycerol kinase GK Tbio Kinase -1.84692 109.0 238
Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB Tchem Kinase -2.93125 790.1 1824
Surfeit locus protein 1 SURF1 Tbio Non-IDG -2.05564 112.5 104
Protein kinase C zeta type PRKCZ Tchem Kinase -2.13834 126.9 626
Phosphorylase b kinase regulatory subunit alpha, liver isoform PHKA2 Tbio Kinase -2.21111 153.2 59