Development Level

Tbio 22 | 11,445
Tchem 6 | 1,598
Tclin 3 | 613

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal embryo size 3 | 220
edema 3 | 59
abnormal kidney morphology 2 | 65
abnormal lens morphology 2 | 81
cataract 2 | 92
decreased vertical activity 2 | 208
preweaning lethality, incomple... 2 | 499
abnormal behavioral response t... 1 | 66
abnormal craniofacial morpholo... 1 | 33
abnormal embryo development 1 | 7
abnormal embryo turning 1 | 31
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
abnormal limb morphology 1 | 13
abnormal pericardium morpholog... 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal tail morphology 1 | 25
decreased NK T cell number 1 | 2
decreased circulating bilirubi... 1 | 19
embryonic lethality prior to t... 1 | 278
female infertility 1 | 60
hyperactivity 1 | 148
increased body weight 1 | 25
increased circulating triglyce... 1 | 42
increased heart rate variabili... 1 | 7
increased mean corpuscular hem... 1 | 96
increased startle reflex 1 | 112
male infertility 1 | 123
microphthalmia 1 | 26
pallor 1 | 34
polycystic kidney 1 | 15
prenatal lethality prior to he... 1 | 87
small superior vagus ganglion 1 | 74

Disease

Carcinoma 24 | 11,493
osteosarcoma 23 | 7,950
ovarian cancer 21 | 8,520
atypical teratoid / rhabdoid tumor 17 | 5,112
glioblastoma 17 | 5,792
ependymoma 16 | 4,679
group 3 medulloblastoma 16 | 4,104
lung cancer 16 | 4,740
Breast cancer 15 | 3,578
Cancer 15 | 2,499
medulloblastoma, large-cell 15 | 6,241
psoriasis 14 | 6,694
malignant mesothelioma 12 | 3,232
Intellectual disability 11 | 1,016
primitive neuroectodermal tumor 11 | 3,035
pancreatic cancer 10 | 2,398
Dull intelligence 9 | 645
Kidney cancer 9 | 2,613
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Poor school performance 9 | 645
adult high grade glioma 9 | 3,801
Cognitive delay 8 | 608
Epilepsy 8 | 792
Global developmental delay 8 | 608
Mental and motor retardation 8 | 608
Seizures 8 | 596
Short stature 8 | 531
astrocytic glioma 8 | 2,597
lung adenocarcinoma 8 | 2,716
oligodendroglioma 8 | 2,850
Astrocytoma, Pilocytic 7 | 3,081
Broad flat nasal bridge 7 | 236
Coffin-Siris syndrome 7 | 17
Concave bridge of nose 7 | 195
Cryptorchidism 7 | 296
Depressed nasal bridge 7 | 195
Depressed nasal root/bridge 7 | 195
Muscle hypotonia 7 | 571
Nasal bridge wide 7 | 236
Small head 7 | 374
Acquired scoliosis 6 | 281
Carcinoma, Hepatocellular 6 | 228
Curvature of spine 6 | 282
Fetal Growth Retardation 6 | 189
Gastrointestinal Stromal Tumors 6 | 48
Infant, Small for Gestational Age 6 | 176
Intrauterine retardation 6 | 176
Liver carcinoma 6 | 240
Multiple myeloma 6 | 1,332
Strabismus 6 | 270
astrocytoma 6 | 1,146
invasive ductal carcinoma 6 | 2,951
pituitary cancer 6 | 1,972
spina bifida 6 | 1,074
Abnormality of cardiovascular system morphology 5 | 23
Abnormally small eyeball 5 | 97
Coarse facial features 5 | 108
Dandy-Walker Syndrome 5 | 39
Decreased size of eyeball 5 | 97
Depressed nasal ridge 5 | 51
Feeding difficulties in infancy 5 | 175
Generalized hirsutism 5 | 36
Immune system cancer 5 | 140
Joint hyperflexibility 5 | 78
Liver cancer 5 | 604
Lymphoid leukemia 5 | 160
Melanoma 5 | 711
Microphthalmos 5 | 100
Nevoid basal cell carcinoma syndrome 5 | 16
Orbital separation excessive 5 | 244
Pick disease 5 | 1,894
Skin cancer 5 | 469
Thickened facial skin with coarse facial features 5 | 108
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
medulloblastoma 5 | 720
non-small cell lung cancer 5 | 2,890
subependymal giant cell astrocytoma 5 | 2,287
Adenoma 4 | 167
Big calvaria 4 | 147
Bladder Neoplasm 4 | 112
DOID:2627 4 | 94
Deafness 4 | 198
Hearing Loss, Partial 4 | 185
Increased head circumference 4 | 147
Increased size of cranium 4 | 147
Increased size of skull 4 | 147
Rheumatoid arthritis 4 | 1,191
Stomach Neoplasms 4 | 300
Urinary Bladder Neoplasms 4 | 114
acute myeloid leukemia 4 | 783
breast carcinoma 4 | 1,638
colon cancer 4 | 1,478
cystic fibrosis 4 | 1,696
diabetes mellitus 4 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
nasopharyngeal carcinoma 4 | 1,058
pediatric high grade glioma 4 | 1,064
progressive supranuclear palsy 4 | 676

Tissue

Digestive Tract 30 | 17,369
Endocrine System 30 | 18,159
Liver and Pancreas 30 | 16,750
Nervous System 30 | 16,725
Skin and soft tissues 30 | 17,230
Blood and immune system 29 | 16,909
Female tissues 29 | 17,400
Male tissues 29 | 17,142
Respiratory system 29 | 16,393
Cardiovascular System 28 | 15,192
Urinary Tract 28 | 16,678

Target Family

Non-IDG 13 | 12,091
Transcription Factor 7 | 1,400
Epigenetic 5 | 242
Kinase 2 | 634
TF/Epigenetic 2 | 38
Enzyme 1 | 4,145
GPCR 1 | 408

WikiPathways Pathway

Tumor suppressor activity of S... 31 | 31
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Smoothened homolog SMO Tclin GPCR -1.17466 14.5 415
Actin-like protein 6B ACTL6B Tbio Non-IDG -0.88819 7.82 127
Zinc finger protein GLI4 GLI4 Tbio Transcription Factor -0.12494 1.92 121
AT-rich interactive domain-containing protein 1B ARID1B Tbio Transcription Factor -1.88304 66.9 120
Retinoblastoma-associated protein RB1 Tchem Non-IDG -3.07052 1137.4 2150
Zinc finger protein neuro-d4 DPF1 Tbio Epigenetic -0.99036 9.89 130
AT-rich interactive domain-containing protein 1A ARID1A Tbio Transcription Factor -2.61778 423.3 132
SWI/SNF complex subunit SMARCC1 SMARCC1 Tbio TF/Epigenetic -1.82146 65.9 148
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 SMARCD2 Tbio Non-IDG -0.94452 9.88 94
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 SMARCD3 Tbio Non-IDG -1.30404 22.1 170