Development Level

Tbio 23 | 11,445
Tchem 16 | 1,598
Tclin 6 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal behavior 3 | 298
abnormal lens morphology 2 | 81
abnormal seminal vesicle morph... 2 | 114
decreased mean corpuscular vol... 2 | 79
hypoactivity 2 | 132
increased lean body mass 2 | 172
increased startle reflex 2 | 112
abnormal QT variability 1 | 10
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal embryo size 1 | 220
abnormal heart left ventricle ... 1 | 16
abnormal heart morphology 1 | 162
abnormal response to tactile s... 1 | 17
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
abnormal sensory capabilities-... 1 | 8
abnormal skin morphology 1 | 50
abnormal startle reflex 1 | 15
cataract 1 | 92
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alkaline... 1 | 46
decreased circulating bilirubi... 1 | 19
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating lipase l... 1 | 3
decreased circulating potassiu... 1 | 20
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased prepulse inhibition 1 | 82
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
edema 1 | 59
enlarged heart 1 | 210
enlarged seminal vesicle 1 | 10
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased bone mineral density 1 | 72
increased cardiac muscle contr... 1 | 8
increased circulating alkaline... 1 | 122
increased circulating creatini... 1 | 38
increased circulating fructosa... 1 | 13
increased circulating potassiu... 1 | 29
increased erythrocyte cell num... 1 | 39
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
increased total body fat amoun... 1 | 134
male infertility 1 | 123
microphthalmia 1 | 26
preweaning lethality, incomple... 1 | 499
small superior vagus ganglion 1 | 74

Disease

Carcinoma 36 | 11,493
ovarian cancer 26 | 8,520
psoriasis 26 | 6,694
lung cancer 21 | 4,740
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,962
interstitial cystitis 15 | 2,312
osteosarcoma 15 | 7,950
ependymoma 14 | 4,679
invasive ductal carcinoma 14 | 2,951
medulloblastoma, large-cell 14 | 6,241
Autosomal recessive predisposition 13 | 1,442
Cancer 13 | 2,499
ductal carcinoma in situ 13 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
pituitary cancer 13 | 1,972
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
lung carcinoma 12 | 2,843
group 3 medulloblastoma 11 | 4,104
lung adenocarcinoma 11 | 2,716
Prostatic Neoplasms 10 | 495
Schizophrenia 10 | 1,160
adrenocortical carcinoma 10 | 1,428
breast carcinoma 10 | 1,638
colon cancer 10 | 1,478
glioblastoma 10 | 5,792
tuberculosis 10 | 2,010
Atopic dermatitis 9 | 952
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
malignant mesothelioma 9 | 3,232
pancreatic cancer 9 | 2,398
Alcoholic Intoxication, Chronic 8 | 289
Breast cancer 8 | 3,578
Liver Cirrhosis, Experimental 8 | 769
Obesity 8 | 678
atypical teratoid / rhabdoid tumor 8 | 5,112
cutaneous lupus erythematosus 8 | 1,057
non-small cell lung cancer 8 | 2,890
Breast Neoplasms 7 | 445
Mammary Neoplasms 7 | 425
adult high grade glioma 7 | 3,801
oligodendroglioma 7 | 2,850
Astrocytoma, Pilocytic 6 | 3,081
Autistic Disorder 6 | 364
Bipolar Disorder 6 | 666
Cognitive delay 6 | 608
Dull intelligence 6 | 645
Epilepsy 6 | 792
Global developmental delay 6 | 608
Intellectual disability 6 | 1,016
Low intelligence 6 | 645
Major Depressive Disorder 6 | 301
Mental Retardation 6 | 645
Mental and motor retardation 6 | 608
Mental deficiency 6 | 645
Muscle hypotonia 6 | 571
Poor school performance 6 | 645
Seizures 6 | 596
Unipolar Depression 6 | 250
active Crohn's disease 6 | 922
active ulcerative colitis 6 | 764
astrocytic glioma 6 | 2,597
primitive neuroectodermal tumor 6 | 3,035
ulcerative colitis 6 | 1,819
Alcohol dependence 5 | 107
Alzheimer's disease 5 | 658
Depressive disorder 5 | 409
Fatty Liver 5 | 70
Hepatomegaly 5 | 285
Hypertension 5 | 396
Kidney cancer 5 | 2,613
Liver disease 5 | 237
Mental Depression 5 | 333
Muscle Spasticity 5 | 195
acute quadriplegic myopathy 5 | 1,158
cystic fibrosis 5 | 1,696
diabetes mellitus 5 | 1,728
esophageal adenocarcinoma 5 | 737
primary Sjogren syndrome 5 | 735
Cardiomegaly 4 | 116
Chemical and Drug Induced Liver Injury 4 | 195
Cholestasis 4 | 155
Diarrhea 4 | 253
Endometriosis 4 | 540
Feeding difficulties in infancy 4 | 175
Hyperreflexia 4 | 209
Hypotension 4 | 82
Male infertility 4 | 206
Melanoma 4 | 711
Metabolic acidosis 4 | 90
Nystagmus 4 | 317
Parkinson's disease 4 | 392
Pellagra 4 | 26
Precancerous Conditions 4 | 80
Waldenstrons macroglobulinemia 4 | 765
chronic rhinosinusitis 4 | 512
dermatomyositis 4 | 966
fibroadenoma 4 | 559
head and neck cancer and chronic obstructive pulmonary disease 4 | 239
juvenile dermatomyositis 4 | 1,187
subependymal giant cell astrocytoma 4 | 2,287

Tissue

Endocrine System 46 | 18,159
Blood and immune system 45 | 16,909
Digestive Tract 45 | 17,369
Female tissues 45 | 17,400
Liver and Pancreas 45 | 16,750
Respiratory system 45 | 16,393
Male tissues 43 | 17,142
Nervous System 43 | 16,725
Skin and soft tissues 43 | 17,230
Urinary Tract 43 | 16,678
Cardiovascular System 39 | 15,192

Target Family

Enzyme 36 | 4,145
Non-IDG 9 | 12,091
Epigenetic 1 | 242

WikiPathways Pathway

Tryptophan metabolism 46 | 46
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Retinal dehydrogenase 2 ALDH1A2 Tbio Enzyme -2.25078 175.3 229
Amine oxidase [flavin-containing] B MAOB Tclin Enzyme -3.40865 2530.3 252
4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 Tbio Enzyme -1.43954 27.0 162
Aromatic-L-amino-acid decarboxylase DDC Tclin Enzyme -2.78263 593.3 412
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH Tbio Enzyme -2.48697 296.4 389
2-oxoglutarate dehydrogenase, mitochondrial OGDH Tbio Enzyme -2.47825 290.5 147
Indoleamine 2,3-dioxygenase 1 IDO1 Tchem Enzyme -2.62196 421.1 684
Kynureninase KYNU Tchem Enzyme -1.61116 39.2 173
Tryptophan--tRNA ligase, cytoplasmic WARS Tbio Enzyme -2.74520 518.6 163
Retinal dehydrogenase 1 ALDH1A1 Tchem Enzyme -2.81062 648.3 725