Development Level

Tbio 10 | 11,445
Tchem 6 | 1,598

IMPC Phenotype

abnormal embryo size 2 | 220
abnormal heart morphology 2 | 162
abnormal seminal vesicle morph... 2 | 114
enlarged heart 2 | 210
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal brain morphology 1 | 13
abnormal neural tube morpholog... 1 | 12
abnormal sensory capabilities-... 1 | 8
abnormal skin morphology 1 | 50
decreased body length 1 | 101
decreased circulating insulin ... 1 | 76
decreased circulating potassiu... 1 | 20
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased lymphocyte cell numb... 1 | 83
decreased vertical activity 1 | 208
edema 1 | 59
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged seminal vesicle 1 | 10
female infertility 1 | 60
hydroencephaly 1 | 14
hydrometra 1 | 53
increased circulating fructosa... 1 | 13
increased circulating potassiu... 1 | 29
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
microphthalmia 1 | 26
pale yolk sac 1 | 25
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499
small superior vagus ganglion 1 | 74

Disease

ovarian cancer 9 | 8,520
Carcinoma 7 | 11,493
osteosarcoma 7 | 7,950
glioblastoma 6 | 5,792
interstitial cystitis 6 | 2,312
invasive ductal carcinoma 6 | 2,951
psoriasis 6 | 6,694
Pellagra 5 | 26
cystic fibrosis 5 | 1,696
ductal carcinoma in situ 5 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
lung cancer 5 | 4,740
malignant mesothelioma 5 | 3,232
pancreatic cancer 5 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
tuberculosis 5 | 2,010
Breast cancer 4 | 3,578
adult high grade glioma 4 | 3,801
astrocytic glioma 4 | 2,597
cutaneous lupus erythematosus 4 | 1,057
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
lung carcinoma 4 | 2,843
medulloblastoma, large-cell 4 | 6,241
pituitary cancer 4 | 1,972
primary Sjogren syndrome 4 | 735
ulcerative colitis 4 | 1,819
Astrocytoma, Pilocytic 3 | 3,081
Liver Cirrhosis, Experimental 3 | 769
Major Depressive Disorder 3 | 301
Pick disease 3 | 1,894
Schizophrenia 3 | 1,160
Unipolar Depression 3 | 250
adrenocortical carcinoma 3 | 1,428
breast carcinoma 3 | 1,638
ependymoma 3 | 4,679
group 3 medulloblastoma 3 | 4,104
non-small cell lung cancer 3 | 2,890
oligodendroglioma 3 | 2,850
primitive neuroectodermal tumor 3 | 3,035
subependymal giant cell astrocytoma 3 | 2,287
Cancer 2 | 2,499
Dermatitis, Allergic Contact 2 | 67
Huntington's disease 2 | 76
Inflammation 2 | 120
Macular degeneration 2 | 65
Neurodegenerative Diseases 2 | 38
Neurodegenerative Disorders 2 | 79
Obesity 2 | 678
Polycystic ovary syndrome 2 | 360
active Crohn's disease 2 | 922
atypical teratoid / rhabdoid tumor 2 | 5,112
group 4 medulloblastoma 2 | 1,855
head and neck cancer 2 | 271
head and neck cancer and chronic obstructive pulmonary disease 2 | 239
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
mucosa-associated lymphoid tissue lymphoma 2 | 484
non primary Sjogren syndrome sicca 2 | 891
primary pancreatic ductal adenocarcinoma 2 | 1,109
urothelial carcinoma 2 | 318
Amyotrophic lateral sclerosis 1 | 451
Atherosclerosis 1 | 291
Atopic dermatitis 1 | 952
Autistic Disorder 1 | 364
Blindness 1 | 88
Breast Neoplasms 1 | 445
Colitis 1 | 54
Colorectal Neoplasms 1 | 243
Congenital deafness 1 | 185
Deafness 1 | 198
Down syndrome 1 | 499
Hearing Loss, Partial 1 | 185
Hyperandrogenism 1 | 34
Hypertension 1 | 396
Leber congenital amaurosis 1 | 69
Mammary Neoplasms 1 | 425
Mouth Neoplasms 1 | 55
Multiple Sclerosis 1 | 540
Muscle Hypertonia 1 | 88
Narcolepsy 1 | 72
Psychotic Disorders 1 | 151
Retinal Degeneration 1 | 106
Rickets 1 | 49
Systemic lupus erythematosus 1 | 194
Tachycardia 1 | 43
Type 2 diabetes mellitus 1 | 272
Waldenstrons macroglobulinemia 1 | 765
Weight Gain 1 | 100
active ulcerative colitis 1 | 764
chronic lymphosyte leukemia 1 | 204
chronic rhinosinusitis 1 | 512
fibroadenoma 1 | 559
hearing impairment 1 | 199
hepatocellular carcinoma 1 | 547
medulloblastoma 1 | 720
nutritional deficiency disease 1 | 9
pediatric high grade glioma 1 | 1,064
permanent atrial fibrillation 1 | 45
posterior fossa group A ependymoma 1 | 468
progressive supranuclear palsy 1 | 676
sarcoidosis 1 | 370

Tissue

Blood and immune system 16 | 16,909
Digestive Tract 16 | 17,369
Endocrine System 16 | 18,159
Female tissues 16 | 17,400
Liver and Pancreas 16 | 16,750
Male tissues 16 | 17,142
Respiratory system 16 | 16,393
Skin and soft tissues 16 | 17,230
Urinary Tract 16 | 16,678
Cardiovascular System 15 | 15,192
Nervous System 15 | 16,725

Target Family

Enzyme 14 | 4,145
Kinase 2 | 634

WikiPathways Pathway

Tryptophan catabolism leading ... 16 | 16
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nicotinamide riboside kinase 1 NMRK1 Tbio Kinase -0.84939 6.66 143
Glutamine-dependent NAD(+) synthetase NADSYN1 Tbio Enzyme -1.21917 15.2 60
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 NMNAT2 Tbio Enzyme -1.54038 36.0 111
Kynureninase KYNU Tchem Enzyme -1.61116 39.2 173
Indoleamine 2,3-dioxygenase 1 IDO1 Tchem Enzyme -2.62196 421.1 684
Kynurenine formamidase AFMID Tbio Enzyme -1.65562 44.8 67
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial AADAT Tchem Enzyme -2.22788 165.9 215
3-hydroxyanthranilate 3,4-dioxygenase HAAO Tbio Enzyme -1.76359 56.1 114
Nicotinamide phosphoribosyltransferase NAMPT Tchem Enzyme -2.94790 1054.3 667
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 NMNAT3 Tbio Enzyme -1.31765 20.1 141