Development Level

Tbio 11 | 11,445
Tchem 1 | 1,598
Tclin 1 | 613

IMPC Phenotype

embryonic lethality prior to t... 2 | 278
preweaning lethality, complete... 2 | 979
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal ovary morphology 1 | 7
absent epididymis 1 | 3
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
increased or absent threshold ... 1 | 101

Disease

Cancer 10 | 2,499
psoriasis 9 | 6,694
invasive ductal carcinoma 8 | 2,951
malignant mesothelioma 8 | 3,232
Carcinoma 7 | 11,493
Obesity 7 | 678
glioblastoma 7 | 5,792
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
lung cancer 7 | 4,740
pituitary cancer 7 | 1,972
medulloblastoma, large-cell 6 | 6,241
osteosarcoma 6 | 7,950
ovarian cancer 6 | 8,520
pancreatic cancer 6 | 2,398
ulcerative colitis 6 | 1,819
Breast cancer 5 | 3,578
Carcinoma, Hepatocellular 5 | 228
Liver carcinoma 5 | 240
astrocytoma 5 | 1,146
breast carcinoma 5 | 1,638
diabetes mellitus 5 | 1,728
group 4 medulloblastoma 5 | 1,855
interstitial cystitis 5 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
lung adenocarcinoma 5 | 2,716
lung carcinoma 5 | 2,843
Schizophrenia 4 | 1,160
adrenocortical carcinoma 4 | 1,428
ductal carcinoma in situ 4 | 1,745
fibroadenoma 4 | 559
group 3 medulloblastoma 4 | 4,104
non-small cell lung cancer 4 | 2,890
Atherosclerosis 3 | 291
Fatty Liver 3 | 70
Leukemia, Myelocytic, Acute 3 | 120
Leukemia, Myeloid, Acute 3 | 105
acute quadriplegic myopathy 3 | 1,158
ependymoma 3 | 4,679
non primary Sjogren syndrome sicca 3 | 891
primitive neuroectodermal tumor 3 | 3,035
subependymal giant cell astrocytoma 3 | 2,287
Alzheimer's disease 2 | 658
Asthma 2 | 385
Atopic dermatitis 2 | 952
Autosomal recessive predisposition 2 | 1,442
Bipolar Disorder 2 | 666
Carcinoma, Squamous Cell 2 | 110
Diabetes Mellitus, Experimental 2 | 108
Fatty liver disease 2 | 103
Female infertility 2 | 30
Hematologic cancer 2 | 12
Highly variable clinical phenotype 2 | 150
Highly variable phenotype and severity 2 | 150
Highly variable phenotype, even within families 2 | 150
Hyperglycemia 2 | 137
Hyperinsulinism 2 | 133
Immune system cancer 2 | 140
Infertility, Female 2 | 28
Inflammation 2 | 120
Insulin Resistance 2 | 72
Leukemia, Acute Myeloid 2 | 17
Lipid metabolism disorder 2 | 114
Lipodystrophy 2 | 40
Liver Cirrhosis, Experimental 2 | 769
Liver disease 2 | 237
Multiple myeloma 2 | 1,332
Myocardial Ischemia 2 | 169
Pancreatic Neoplasm 2 | 85
Pancreatic Neoplasms 2 | 85
Parkinson's disease 2 | 392
Phenotypic variability 2 | 150
Pulmonary Fibrosis 2 | 106
Rheumatoid arthritis 2 | 1,191
Squamous cell carcinoma 2 | 129
atypical teratoid / rhabdoid tumor 2 | 5,112
chronic lymphosyte leukemia 2 | 204
cutaneous lupus erythematosus 2 | 1,057
gastric carcinoma 2 | 807
inflammatory breast cancer 2 | 286
mucosa-associated lymphoid tissue lymphoma 2 | 484
primary pancreatic ductal adenocarcinoma 2 | 1,109
tuberculosis 2 | 2,010
Asbestosis 1 | 20
Asphyxiating thoracic dystrophy 1 1 | 2
Asphyxiating thoracic dystrophy 2 1 | 2
Charcot-Marie-Tooth disease type 3 1 | 6
Claw hand 1 | 26
Dyslipidemias 1 | 27
Dysthymic Disorder 1 | 17
Foot dorsiflexor weakness 1 | 27
Foot-drop 1 | 27
Gait, Drop Foot 1 | 24
Myoepithelial carcinoma 1 | 4
Oligomenorrhea 1 | 16
Peripheral hypomyelination 1 | 7
Personality disorder 1 | 25
Prolactinoma 1 | 11
Seasonal affective disorder 1 | 28
hypoparathyroidism-deafness-renal disease syndrome 1 | 6

Tissue

Blood and immune system 13 | 16,909
Cardiovascular System 13 | 15,192
Digestive Tract 13 | 17,369
Endocrine System 13 | 18,159
Female tissues 13 | 17,400
Liver and Pancreas 13 | 16,750
Male tissues 13 | 17,142
Respiratory system 13 | 16,393
Skin and soft tissues 13 | 17,230
Urinary Tract 13 | 16,678
Nervous System 12 | 16,725

Target Family

Transcription Factor 12 | 1,400
Nuclear Receptor 1 | 48

WikiPathways Pathway

Transcriptional cascade regula... 13 | 13
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Krueppel-like factor 2 KLF2 Tbio Transcription Factor -2.30630 216.2 308
CCAAT/enhancer-binding protein beta CEBPB Tbio Transcription Factor -2.96589 857.9 436
CCAAT/enhancer-binding protein delta CEBPD Tbio Transcription Factor -2.49029 299.9 179
CCAAT/enhancer-binding protein alpha CEBPA Tbio Transcription Factor -2.94393 846.3 518
DNA damage-inducible transcript 3 protein DDIT3 Tchem Transcription Factor -2.94434 736.0 704
E3 SUMO-protein ligase EGR2 EGR2 Tbio Transcription Factor -2.55244 341.9 344
CCAAT/enhancer-binding protein gamma CEBPG Tbio Transcription Factor -0.92558 8.45 248
Krueppel-like factor 15 KLF15 Tbio Transcription Factor -1.86592 80.5 245
Krueppel-like factor 5 KLF5 Tbio Transcription Factor -2.24489 208.0 218
Peroxisome proliferator-activated receptor gamma PPARG Tclin Nuclear Receptor -3.96393 9579.5 773