Development Level

Tbio 18 | 11,445
Tchem 8 | 1,598
Tclin 4 | 613
Tdark 2 | 6,588

IMPC Phenotype

preweaning lethality, complete... 7 | 979
embryonic lethality prior to o... 3 | 239
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
abnormal heart morphology 2 | 162
abnormal retina morphology 2 | 71
cataract 2 | 92
decreased circulating HDL chol... 2 | 68
decreased total body fat amoun... 2 | 207
embryonic lethality prior to t... 2 | 278
increased bone mineral content 2 | 108
increased lean body mass 2 | 172
preweaning lethality, incomple... 2 | 499
abnormal allantois morphology 1 | 8
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal eye morphology 1 | 68
abnormal lens morphology 1 | 81
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal skin morphology 1 | 50
anophthalmia 1 | 33
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased granulocyte number 1 | 6
decreased lean body mass 1 | 135
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
edema 1 | 59
enlarged heart 1 | 210
hypoactivity 1 | 132
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating bilirubi... 1 | 16
increased grip strength 1 | 41
increased mean platelet volume 1 | 45
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
microphthalmia 1 | 26
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small adrenal glands 1 | 16
thrombocytopenia 1 | 56

Disease

Carcinoma 23 | 11,493
ovarian cancer 18 | 8,520
osteosarcoma 17 | 7,950
Cancer 16 | 2,499
psoriasis 16 | 6,694
non-small cell lung cancer 15 | 2,890
Autosomal recessive predisposition 14 | 1,442
medulloblastoma, large-cell 14 | 6,241
Schizophrenia 12 | 1,160
group 3 medulloblastoma 12 | 4,104
lung cancer 12 | 4,740
pancreatic cancer 12 | 2,398
glioblastoma 11 | 5,792
atypical teratoid / rhabdoid tumor 10 | 5,112
lung adenocarcinoma 10 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
Breast Neoplasms 9 | 445
Down syndrome 9 | 499
Hyperhomocysteinemia 9 | 37
Intellectual disability 9 | 1,016
Mammary Neoplasms 9 | 425
ependymoma 9 | 4,679
malignant mesothelioma 9 | 3,232
Breast cancer 8 | 3,578
Dull intelligence 8 | 645
Epilepsy 8 | 792
Homocystinuria 8 | 21
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Poor school performance 8 | 645
Seizures 8 | 596
adrenocortical carcinoma 8 | 1,428
Cleft Lip 7 | 141
Cleft Palate 7 | 271
Cognitive delay 7 | 608
Global developmental delay 7 | 608
Mental and motor retardation 7 | 608
colon cancer 7 | 1,478
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
invasive ductal carcinoma 7 | 2,951
nasopharyngeal carcinoma 7 | 1,058
oligodendroglioma 7 | 2,850
primitive neuroectodermal tumor 7 | 3,035
spina bifida 7 | 1,074
Anemia 6 | 365
Hypermethioninemia 6 | 11
Kidney cancer 6 | 2,613
Prostatic Neoplasms 6 | 495
adult high grade glioma 6 | 3,801
ductal carcinoma in situ 6 | 1,745
interstitial cystitis 6 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
tuberculosis 6 | 2,010
Adverse reaction to drug 5 | 61
Bipolar Disorder 5 | 666
Drug-Related Side Effects and Adverse Reactions 5 | 62
Lymphoma, Non-Hodgkin 5 | 24
hepatocellular carcinoma 5 | 547
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
pancreatic carcinoma 5 | 562
progressive supranuclear palsy 5 | 676
Adenocarcinoma of lung 4 | 142
Amino Acid Metabolism, Inborn Errors 4 | 13
Astrocytoma, Pilocytic 4 | 3,081
Atherosclerosis 4 | 291
Carcinoma, Non-Small-Cell Lung 4 | 107
Dementia 4 | 175
Depressive disorder 4 | 409
Disease Models, Animal 4 | 155
Fetal Growth Retardation 4 | 189
Hypertension 4 | 396
Lung Neoplasms 4 | 232
MYELODYSPLASTIC SYNDROME 4 | 53
Nervous System Diseases 4 | 53
Polycystic ovary syndrome 4 | 360
Stomach Neoplasms 4 | 300
Waldenstrons macroglobulinemia 4 | 765
acute quadriplegic myopathy 4 | 1,158
astrocytic glioma 4 | 2,597
astrocytoma 4 | 1,146
atypical teratoid/rhabdoid tumor 4 | 357
cystic fibrosis 4 | 1,696
diabetes mellitus 4 | 1,728
group 4 medulloblastoma 4 | 1,855
immunodeficiency-centromeric instability-facial anomalies syndrome 4 | 16
nervous system disorder 4 | 53
non-small cell lung carcinoma 4 | 317
primary Sjogren syndrome 4 | 735
subependymal giant cell astrocytoma 4 | 2,287
ulcerative colitis 4 | 1,819
Alzheimer's disease 3 | 658
Atopic dermatitis 3 | 952
Male infertility 3 | 206
breast carcinoma 3 | 1,638
chronic rhinosinusitis 3 | 512
dermatomyositis 3 | 966
gastric carcinoma 3 | 807
pituitary cancer 3 | 1,972
primary pancreatic ductal adenocarcinoma 3 | 1,109

Tissue

Digestive Tract 32 | 17,369
Endocrine System 32 | 18,159
Female tissues 32 | 17,400
Liver and Pancreas 32 | 16,750
Nervous System 32 | 16,725
Skin and soft tissues 32 | 17,230
Urinary Tract 32 | 16,678
Blood and immune system 31 | 16,909
Male tissues 31 | 17,142
Cardiovascular System 30 | 15,192
Respiratory system 30 | 16,393

Target Family

Enzyme 29 | 4,145
Epigenetic 2 | 242
Non-IDG 1 | 12,091

WikiPathways Pathway

Trans-sulfuration and one carb... 32 | 32
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
D-3-phosphoglycerate dehydrogenase PHGDH Tbio Enzyme -3.17330 1408.2 293
Methylenetetrahydrofolate reductase MTHFR Tbio Enzyme -3.68447 5032.2 275
Methionine synthase MTR Tbio Enzyme -2.56900 300.2 87
DNA (cytosine-5)-methyltransferase 1 DNMT1 Tclin Enzyme -3.21333 1562.7 1125
Cystathionine beta-synthase-like protein CBS Tbio Non-IDG -3.25635 3246.1 0
Thymidylate synthase TYMS Tclin Enzyme -2.93426 732.0 733
Glutathione synthetase GSS Tbio Enzyme -2.78139 592.8 229
Dihydrofolate reductase DHFR Tclin Enzyme -2.99192 972.8 202
C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 Tbio Enzyme -1.97029 90.6 101
Cystathionine beta-synthase CBS Tchem Enzyme -3.25635 3246.1 391