Development Level

Tbio 43 | 11,651
Tchem 41 | 1,388
Tclin 15 | 612
Tdark 2 | 6,593

IMPC Phenotype

preweaning lethality, complete... 5 | 979
decreased body weight 3 | 161
decreased circulating creatini... 3 | 39
decreased mean corpuscular vol... 3 | 79
preweaning lethality, incomple... 3 | 499
abnormal gait 2 | 69
decreased vertical activity 2 | 208
embryonic lethality prior to t... 2 | 278
increased circulating alkaline... 2 | 122
increased lymphocyte cell numb... 2 | 32
increased neutrophil cell numb... 2 | 46
small superior vagus ganglion 2 | 74
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal cecum morphology 1 | 7
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal glucose homeostasis 1 | 4
abnormal lens morphology 1 | 81
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal skin condition 1 | 6
abnormal vibrissa morphology 1 | 25
decreased bone mineral content 1 | 151
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased heart weight 1 | 27
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 31
decreased monocyte cell number 1 | 8
decreased neutrophil cell numb... 1 | 42
decreased thermal nociceptive ... 1 | 2
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
enlarged cecum 1 | 5
enlarged lymph nodes 1 | 37
enlarged uterus 1 | 11
impaired righting response 1 | 26
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased eosinophil cell numb... 1 | 11
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
short tibia 1 | 97
thrombocytosis 1 | 27
vertebral fusion 1 | 23

Disease

Cancer 68 | 2,499
Carcinoma 64 | 11,493
glioblastoma 52 | 5,792
ovarian cancer 51 | 8,520
psoriasis 51 | 6,694
lung cancer 45 | 4,740
osteosarcoma 37 | 7,950
adult high grade glioma 34 | 3,801
medulloblastoma, large-cell 34 | 6,241
tuberculosis 34 | 2,010
Arthritis 31 | 290
atypical teratoid / rhabdoid tumor 30 | 5,112
lung carcinoma 29 | 2,843
Asthma 28 | 385
Astrocytoma, Pilocytic 28 | 3,081
Influenza 28 | 142
Multiple Sclerosis 27 | 540
diabetes mellitus 27 | 1,728
interstitial cystitis 26 | 2,312
malignant mesothelioma 25 | 3,232
Breast cancer 24 | 3,578
Hypersensitivity reaction type II disease 24 | 253
Rheumatoid arthritis 24 | 1,191
Inflammatory bowel disease 22 | 151
Schizophrenia 22 | 1,160
cutaneous lupus erythematosus 22 | 1,057
invasive ductal carcinoma 22 | 2,951
ulcerative colitis 22 | 1,819
ependymoma 21 | 4,679
subependymal giant cell astrocytoma 21 | 2,287
Lung disease 20 | 142
Vascular disease 19 | 319
cystic fibrosis 19 | 1,696
juvenile dermatomyositis 19 | 1,187
non-small cell lung cancer 19 | 2,890
Kidney disease 18 | 430
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,989
Breast Neoplasms 17 | 445
Mammary Neoplasms 17 | 425
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
lung adenocarcinoma 17 | 2,716
pancreatic cancer 17 | 2,398
Kidney cancer 16 | 2,613
Lung Neoplasms 16 | 232
Obesity 16 | 678
Pneumonia 16 | 174
Reperfusion Injury 16 | 86
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,955
Dermatitis 15 | 157
Liver disease 15 | 237
Malaria 15 | 160
Allergic hypersensitivity disease 14 | 126
Atherosclerosis 14 | 291
Brain Ischemia 14 | 110
Liver Cirrhosis, Experimental 14 | 769
Liver carcinoma 14 | 240
breast carcinoma 14 | 1,638
group 4 medulloblastoma 14 | 1,855
Autosomal recessive predisposition 13 | 1,442
Cholestasis, Extrahepatic 13 | 25
Hepatitis B 13 | 108
Hepatitis C 13 | 94
Human immunodeficiency virus infectious disease 13 | 138
Seizures 13 | 596
Brain Injuries 12 | 65
Carcinoma, Hepatocellular 12 | 228
Depressive disorder 12 | 409
Immunologic Deficiency Syndromes 12 | 113
Inflammation 12 | 120
Meningitis 12 | 67
Neoplasm Metastasis 12 | 168
Prostatic Neoplasms 12 | 495
acute myeloid leukemia 12 | 783
dermatomyositis 12 | 966
hepatocellular carcinoma 12 | 547
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
Arthritis, Rheumatoid 11 | 174
Coronary artery disease 11 | 268
Diarrhea 11 | 253
Encephalitis 11 | 64
Epilepsy 11 | 792
Hypertension 11 | 396
Stomach Neoplasms 11 | 300
colon cancer 11 | 1,478
group 3 medulloblastoma 11 | 4,104
pancreatic carcinoma 11 | 562
pituitary cancer 11 | 1,972
primitive neuroectodermal tumor 11 | 3,035
Alzheimer's disease 10 | 658
Bipolar Disorder 10 | 666
Endometriosis 10 | 540
Heart disease 10 | 306
Leishmaniasis 10 | 47
Multiple myeloma 10 | 1,332
active Crohn's disease 10 | 922
astrocytoma 10 | 1,146
ductal carcinoma in situ 10 | 1,745
gastric cancer 10 | 459
nasopharyngeal carcinoma 10 | 1,058
primary Sjogren syndrome 10 | 735

Tissue

Blood and immune system 91 | 16,909
Male tissues 90 | 17,142
Nervous System 89 | 16,725
Urinary Tract 89 | 16,678
Digestive Tract 88 | 17,369
Endocrine System 88 | 18,159
Female tissues 88 | 17,400
Liver and Pancreas 88 | 16,750
Skin and soft tissues 88 | 17,230
Respiratory system 87 | 16,393
Cardiovascular System 83 | 15,192

Target Family

Non-IDG 52 | 12,091
Kinase 34 | 634
Transcription Factor 9 | 1,400
Enzyme 6 | 4,145

WikiPathways Pathway

Toll-like Receptor Signaling P... 101 | 101
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
Interleukin-1 receptor-associated kinase 4 IRAK4 Tchem Kinase -2.28820 202.2 610
Myeloid differentiation primary response protein MyD88 MYD88 Tbio Non-IDG -3.26747 1795.4 672
TNF receptor-associated factor 6 TRAF6 Tbio Non-IDG -2.74221 511.1 403
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.94674 87.1 452
Dual specificity mitogen-activated protein kinase kinase 6 MAP2K6 Tchem Kinase -2.01763 74.4 636
Nuclear factor NF-kappa-B p100 subunit NFKB2 Tchem Transcription Factor -2.29577 191.3 637
Mitogen-activated protein kinase kinase kinase 7 MAP3K7 Tchem Kinase -1.46817 32.4 765
Mitogen-activated protein kinase 12 MAPK12 Tchem Kinase -1.95173 88.4 378