Development Level

Tchem 48 | 1,890
Tbio 36 | 10,625
Tclin 14 | 602
Tdark 3 | 7,003

IMPC Phenotype

preweaning lethality, complete... 4 | 633
decreased body weight 3 | 174
decreased circulating creatini... 3 | 31
decreased lean body mass 3 | 195
decreased KLRG1+ CD8 alpha bet... 2 | 8
decreased Ly6C low monocyte nu... 2 | 23
decreased bone mineral content 2 | 157
decreased mean corpuscular vol... 2 | 50
decreased monocyte cell number 2 | 28
embryonic lethality prior to t... 2 | 187
increased NK cell number 2 | 19
increased circulating alkaline... 2 | 119
increased erythrocyte cell num... 2 | 26
small superior vagus ganglion 2 | 20
abnormal bone mineralization 1 | 55
abnormal coping response 1 | 12
abnormal cornea morphology 1 | 24
abnormal embryo size 1 | 112
abnormal forebrain development 1 | 18
abnormal gait 1 | 51
abnormal glucose homeostasis 1 | 5
abnormal hindbrain development 1 | 24
abnormal lens morphology 1 | 73
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal respiratory quotient 1 | 9
abnormal skin condition 1 | 6
decreased B cell number 1 | 30
decreased CD4-positive, CD25-p... 1 | 24
decreased CD5-positive Ly6C-po... 1 | 4
decreased body length 1 | 108
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating amylase ... 1 | 24
decreased circulating choleste... 1 | 85
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased effector memory CD4-... 1 | 6
decreased effector memory CD8-... 1 | 24
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased lumbar vertebrae num... 1 | 62
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular hem... 1 | 19
decreased neutrophil cell numb... 1 | 37
decreased thermal nociceptive ... 1 | 4
decreased total body fat amoun... 1 | 186
enlarged lymph nodes 1 | 27
increased B cell number 1 | 23
increased body weight 1 | 42
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating choleste... 1 | 53
increased circulating free fat... 1 | 17
increased fasted circulating g... 1 | 68
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
increased mature B cell number 1 | 12
increased mean corpuscular hem... 1 | 93
increased thermal nociceptive ... 1 | 9
polydactyly 1 | 22
preweaning lethality, incomple... 1 | 260
thrombocytosis 1 | 23
vertebral fusion 1 | 23

Disease

Cancer 65 | 2,346
ovarian cancer 51 | 8,491
psoriasis 51 | 6,685
glioblastoma 48 | 5,572
lung cancer 43 | 4,473
osteosarcoma 37 | 7,933
medulloblastoma, large-cell 34 | 6,234
tuberculosis 32 | 1,563
lung carcinoma 29 | 2,844
Influenza 28 | 142
atypical teratoid / rhabdoid tumor 28 | 4,369
pilocytic astrocytoma 28 | 3,086
Multiple Sclerosis 27 | 498
ulcerative colitis 27 | 2,087
Arthritis 26 | 248
Asthma 26 | 349
interstitial cystitis 26 | 2,299
diabetes mellitus 25 | 1,663
Rheumatoid Arthritis 24 | 1,170
cutaneous lupus erythematosus 22 | 1,056
invasive ductal carcinoma 22 | 2,950
malignant mesothelioma 22 | 3,163
Hypersensitivity reaction type II disease 21 | 235
subependymal giant cell astrocytoma 21 | 2,287
Inflammatory bowel disease 19 | 142
Lung disease 19 | 136
adult high grade glioma 19 | 2,148
juvenile dermatomyositis 19 | 1,189
non-small cell lung cancer 19 | 2,798
pediatric high grade glioma 19 | 2,712
Breast cancer 18 | 3,098
Vascular disease 18 | 281
cystic fibrosis 18 | 1,670
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,988
Kidney disease 17 | 397
Mammary Neoplasms 17 | 410
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,289
lung adenocarcinoma 17 | 2,714
Lung Neoplasms 16 | 171
Reperfusion Injury 16 | 84
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,956
pancreatic cancer 16 | 2,300
Carcinoma 15 | 2,147
Brain Ischemia 14 | 87
Dermatitis 14 | 141
Hepatitis B 14 | 103
Liver disease 14 | 219
Obesity 14 | 616
posterior fossa group A ependymoma 14 | 1,511
Atherosclerosis 13 | 275
Pneumonia 13 | 133
primary Sjogren syndrome 13 | 788
Allergic hypersensitivity disease 12 | 123
Hepatitis C 12 | 90
Inflammation 12 | 109
Malaria 12 | 140
Prostatic Neoplasms 12 | 471
acute myeloid leukemia 12 | 785
breast carcinoma 12 | 1,614
dermatomyositis 12 | 966
group 4 medulloblastoma 12 | 1,875
hepatocellular carcinoma 12 | 550
medulloblastoma 12 | 1,524
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,795
Human immunodeficiency virus infectious disease 11 | 129
Meningitis 11 | 46
Toxic encephalopathy 11 | 131
colon cancer 11 | 1,475
ependymoma 11 | 2,514
pancreatic carcinoma 11 | 567
pituitary cancer 11 | 1,972
primitive neuroectodermal tumor 11 | 3,031
Alzheimer's disease 10 | 644
Coronary artery disease 10 | 240
Encephalitis 10 | 54
Heart disease 10 | 279
IGA Glomerulonephritis 10 | 454
Liver carcinoma 10 | 217
Multiple myeloma 10 | 1,327
Neoplasm Metastasis 10 | 138
Stomach Neoplasms 10 | 282
active Crohn's disease 10 | 918
astrocytoma 10 | 1,493
ductal carcinoma in situ 10 | 1,745
nasopharyngeal carcinoma 10 | 1,056
sarcoidosis 10 | 368
Endometriosis 9 | 535
Eye disease 9 | 55
Leishmaniasis 9 | 49
Myocardial Ischemia 9 | 169
Parkinson's disease 9 | 364
Peritonitis 9 | 37
Pick disease 9 | 1,893
Schizophrenia 9 | 503
gastric cancer 9 | 436
gastric carcinoma 9 | 832
mucosa-associated lymphoid tissue lymphoma 9 | 480
oligodendroglioma 9 | 2,849
periodontitis 9 | 269
systemic lupus erythematosus 9 | 172

Tissue

Nervous System 98 | 18,560
Digestive Tract 96 | 18,472
Female tissues 96 | 18,646
Urinary Tract 96 | 18,443
Blood and immune system 93 | 17,994
Skin and soft tissues 92 | 18,114
Endocrine System 91 | 18,511
Liver and Pancreas 90 | 18,135
Cardiovascular System 89 | 17,957
Respiratory system 87 | 17,483
Male tissues 85 | 17,968

Target Family

Non-IDG 52 | 11,969
Kinase 34 | 634
Transcription Factor 9 | 1,400
Enzyme 6 | 4,146

WikiPathways Pathway

Toll-like Receptor Signaling P... 101 | 101
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 257 | 257
Circadian rythm related genes 200 | 200
Integrated Pancreatic Cancer P... 192 | 192
Focal Adhesion 190 | 190
Metapathway biotransformation 172 | 172
MAPK Signaling Pathway 167 | 167
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
Myometrial Relaxation and Cont... 157 | 157
Sudden Infant Death Syndrome (... 157 | 157
Allograft Rejection 156 | 156
Integrated Breast Cancer Pathw... 152 | 152
Calcium Regulation in the Card... 150 | 150
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 128 | 128
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Signaling Pathways in Glioblas... 83 | 83
MicroRNAs in cardiomyocyte hyp... 82 | 82
Alzheimers Disease 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Arrhythmogenic Right Ventricul... 74 | 74
Peptide GPCRs 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Wnt Signaling Pathway 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
IL-1 signaling pathway 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Copper homeostasis 54 | 54
ErbB Signaling Pathway 54 | 54
IL-4 Signaling Pathway 54 | 54
Interferon type I signaling pa... 54 | 54
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54
Apoptosis-related network due ... 53 | 53
Cardiac Hypertrophic Response 53 | 53
Cardiac Progenitor Differentia... 53 | 53
Synaptic Vesicle Pathway 51 | 51
Translation Factors 51 | 51
Wnt Signaling Pathway Netpath 51 | 51

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Lymphocyte antigen 96 LY96 Tbio Non-IDG -2.73333 490.7 314
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.12726 13094.7 961
Mitogen-activated protein kinase 12 MAPK12 Tchem Kinase -1.91165 83.2 324
Mitogen-activated protein kinase 10 MAPK10 Tchem Kinase -2.27384 181.6 339
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TAB2 Tbio Enzyme -1.87718 69.0 145
Toll-like receptor 7 TLR7 Tclin Non-IDG -2.97887 974.2 670
Dual specificity mitogen-activated protein kinase kinase 6 MAP2K6 Tchem Kinase -1.97989 67.5 582
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.87449 73.5 395
Mitogen-activated protein kinase kinase kinase 7 MAP3K7 Tchem Kinase -1.41371 28.0 678
Phosphoinositide 3-kinase regulatory subunit 5 PIK3R5 Tbio Enzyme -1.50034 26.8 198