Development Level

Tbio 16 | 11,445
Tchem 13 | 1,598
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal cecum morphology 1 | 7
abnormal cornea morphology 1 | 31
abnormal skin condition 1 | 6
abnormal vibrissa morphology 1 | 25
absent vibrissae 1 | 12
decreased circulating amylase ... 1 | 28
decreased circulating sodium l... 1 | 22
decreased eosinophil cell numb... 1 | 24
decreased heart weight 1 | 27
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased monocyte cell number 1 | 8
decreased thermal nociceptive ... 1 | 2
enlarged cecum 1 | 5
enlarged uterus 1 | 11
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased eosinophil cell numb... 1 | 11
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
increased thermal nociceptive ... 1 | 9
preweaning lethality, incomple... 1 | 499
small superior vagus ganglion 1 | 74
tremors 1 | 39

Disease

Cancer 24 | 2,499
Carcinoma 24 | 11,493
glioblastoma 17 | 5,792
ovarian cancer 15 | 8,520
tuberculosis 15 | 2,010
psoriasis 14 | 6,694
lung cancer 13 | 4,740
osteosarcoma 11 | 7,950
Influenza 10 | 142
medulloblastoma, large-cell 10 | 6,241
Astrocytoma, Pilocytic 9 | 3,081
adult high grade glioma 9 | 3,801
lung carcinoma 9 | 2,843
Arthritis 8 | 290
Rheumatoid arthritis 8 | 1,191
Asthma 7 | 385
Immunologic Deficiency Syndromes 7 | 113
Pneumonia 7 | 174
Schizophrenia 7 | 1,160
Allergic hypersensitivity disease 6 | 126
Breast cancer 6 | 3,578
Hypersensitivity reaction type II disease 6 | 253
Inflammatory bowel disease 6 | 151
Kidney cancer 6 | 2,613
Multiple Sclerosis 6 | 540
atypical teratoid / rhabdoid tumor 6 | 5,112
cutaneous lupus erythematosus 6 | 1,057
ependymoma 6 | 4,679
interstitial cystitis 6 | 2,312
malignant mesothelioma 6 | 3,232
subependymal giant cell astrocytoma 6 | 2,287
ulcerative colitis 6 | 1,819
Brain Injuries 5 | 65
Heat Stroke 5 | 13
Inflammation 5 | 120
Malaria 5 | 160
Meningitis 5 | 67
Prostatic Neoplasms 5 | 495
Reperfusion Injury 5 | 86
astrocytoma 5 | 1,146
diabetes mellitus 5 | 1,728
pancreatic cancer 5 | 2,398
Arthritis, Rheumatoid 4 | 174
Autosomal recessive predisposition 4 | 1,442
Cholestasis, Extrahepatic 4 | 25
Coronary artery disease 4 | 268
Encephalitis, myelitis and encephalomyelitis in viral diseases classified elsewhere 4 | 5
Eosinophilia 4 | 28
HERPES SIMPLEX ENCEPHALITIS, SUSCEPTIBILITY TO, 1 4 | 5
Herpes encephalitis 4 | 6
Human immunodeficiency virus infectious disease 4 | 138
Hypertension 4 | 396
Keratitis 4 | 62
Liver disease 4 | 237
Neoplasm Invasiveness 4 | 161
Systemic lupus erythematosus 4 | 194
Vascular disease 4 | 319
cystic fibrosis 4 | 1,696
group 3 medulloblastoma 4 | 4,104
hepatocellular carcinoma 4 | 547
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
juvenile dermatomyositis 4 | 1,187
non-small cell lung cancer 4 | 2,890
pancreatic carcinoma 4 | 562
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
primitive neuroectodermal tumor 4 | 3,035
Amyotrophic lateral sclerosis 3 | 451
Bipolar Disorder 3 | 666
Brain Ischemia 3 | 110
Cell Transformation, Neoplastic 3 | 97
Common variable immunodeficiency 3 | 101
Dermatitis 3 | 157
Encephalitis, Herpes Simplex 3 | 4
Fatigue 3 | 182
Hepatitis B 3 | 108
Hypertensive disease 3 | 292
Kidney disease 3 | 430
Leishmaniasis 3 | 47
Lung Neoplasms 3 | 232
Lyme disease 3 | 26
Major Depressive Disorder 3 | 301
Mantle cell lymphoma 3 | 23
Melioidosis 3 | 17
Multiple myeloma 3 | 1,332
Neoplastic Cell Transformation 3 | 89
Neurodegenerative disease 3 | 414
Obesity 3 | 678
Peritonitis 3 | 43
Salmonellosis 3 | 42
Small head 3 | 374
Unipolar Depression 3 | 250
colon cancer 3 | 1,478
gastric cancer 3 | 459
group 4 medulloblastoma 3 | 1,855
invasive ductal carcinoma 3 | 2,951
lung adenocarcinoma 3 | 2,716
oligodendroglioma 3 | 2,850
pituitary cancer 3 | 1,972
primary Sjogren syndrome 3 | 735
Broad cranium shape 2 | 88

Tissue

Blood and immune system 31 | 16,909
Digestive Tract 31 | 17,369
Endocrine System 31 | 18,159
Female tissues 31 | 17,400
Liver and Pancreas 31 | 16,750
Male tissues 31 | 17,142
Nervous System 31 | 16,725
Respiratory system 31 | 16,393
Skin and soft tissues 31 | 17,230
Urinary Tract 31 | 16,678
Cardiovascular System 30 | 15,192

Target Family

Non-IDG 16 | 12,091
Kinase 8 | 634
Transcription Factor 7 | 1,400

WikiPathways Pathway

Toll-like Receptor Signaling 31 | 31
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
TIR domain-containing adapter molecule 2 TICAM2 Tbio Non-IDG -1.18212 14.6 258
Toll-like receptor 7 TLR7 Tclin Non-IDG -3.02761 1078.4 759
Toll-like receptor 9 TLR9 Tclin Non-IDG -3.07216 1172.9 792
Toll-like receptor 8 TLR8 Tchem Non-IDG -2.36315 232.6 645
Toll-like receptor 6 TLR6 Tbio Non-IDG -2.18033 129.1 692
Serine/threonine-protein kinase TBK1 TBK1 Tchem Kinase -2.76728 569.1 455
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.18822 1239.4 1248
TNF receptor-associated factor 6 TRAF6 Tbio Non-IDG -2.74221 511.1 403
Myeloid differentiation primary response protein MyD88 MYD88 Tbio Non-IDG -3.26747 1795.4 672
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879