Development Level

Tbio 4 | 11,651
Tclin 2 | 612

IMPC Phenotype

abnormal sleep behavior 1 | 70
decreased bone mineral density 1 | 126
decreased exploration in new e... 1 | 11
decreased heart rate 1 | 18
decreased prepulse inhibition 1 | 82
decreased urine creatinine lev... 1 | 3
hypoactivity 1 | 132
increased body length 1 | 32
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
prolonged QRS complex duration 1 | 8
prolonged RR interval 1 | 8

Disease

Autosomal recessive predisposition 5 | 1,442
Constipation 5 | 181
Dull intelligence 5 | 645
Dyschezia 5 | 135
Goiter 5 | 38
Hypothyroidism 5 | 122
Intellectual disability 5 | 1,016
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Poor school performance 5 | 645
Short stature 5 | 531
Abdomen distended 4 | 43
Autoimmune thyroiditis 4 | 27
Carcinoma 4 | 11,493
Coarse facial features 4 | 108
Cognitive delay 4 | 608
Congenital hypothyroidism 4 | 26
Fatigue 4 | 182
Global developmental delay 4 | 608
Graves' disease 4 | 24
Hypersomnia 4 | 8
Hyperthyroidism 4 | 53
Icterus 4 | 82
Large bregma sutures 4 | 46
Large fontanelle 4 | 46
Large, late-closing fontanelle 4 | 46
Macroglossia 4 | 65
Mental and motor retardation 4 | 608
Muscle hypotonia 4 | 571
Thickened facial skin with coarse facial features 4 | 108
Thyroiditis 4 | 29
Thyrotoxicosis 4 | 38
Umbilical hernia 4 | 93
Wide bregma sutures 4 | 46
psoriasis 4 | 6,694
Adenoma 3 | 167
Dry skin 3 | 75
Kidney cancer 3 | 2,613
Pendred Syndrome 3 | 22
Thyroid Dyshormonogenesis 1 3 | 6
Xerosis 3 | 75
osteosarcoma 3 | 7,950
Abnormality of metabolism/homeostasis 2 | 134
Addison's disease 2 | 31
Autoimmune Diseases 2 | 67
Cancer 2 | 2,499
Celiac disease 2 | 116
Exophthalmos 2 | 112
Melanoma 2 | 711
Muscle Weakness 2 | 170
Papillary carcinoma 2 | 6
Skin cancer 2 | 469
Tachycardia 2 | 43
Thyroid Neoplasm 2 | 37
Thyroid Neoplasms 2 | 34
Thyroid adenoma 2 | 10
Thyroid cancer 2 | 36
Thyroiditis, Autoimmune 2 | 4
diabetes mellitus 2 | 1,728
facioscapulohumeral dystrophy 2 | 288
group 3 medulloblastoma 2 | 4,104
lung carcinoma 2 | 2,843
Acute cystitis 1 | 35
Adrenal Gland Neoplasms 1 | 11
Adrenal gland cancer 1 | 12
Advanced bone age 1 | 35
Agitation 1 | 16
Amenorrhea 1 | 58
Amnesia 1 | 17
Arrhythmias, Cardiac 1 | 19
Bradycardia 1 | 36
Catalepsy 1 | 15
Compensated hypothyroidism 1 | 5
Conduct disorder 1 | 33
Elevated heart rate 1 | 25
Eye and adnexa disease 1 | 18
Glioma 1 | 74
Graves Disease 1 | 11
Hoarse cry 1 | 5
Hoarseness 1 | 31
Hyperprolactinemia 1 | 27
Hypoparathyroidism 1 | 41
Hypopituitarism 1 | 40
Learning Disorders 1 | 29
Leukemia, Myelocytic, Acute 1 | 120
Leukemia, Myeloid, Acute 1 | 105
Lymphatic Metastasis 1 | 15
Neoplasms 1 | 63
Oligospermia 1 | 36
Ovarian Neoplasms 1 | 102
Pain 1 | 103
Personality disorder 1 | 25
Plummer's disease 1 | 11
Pseudohypoparathyroidism 1 | 18
Seborrheic dermatitis 1 | 31
Thyroid carcinoma 1 | 5
Toxic diffuse goiter 1 | 2
ovarian neoplasm 1 | 99
uncontrolled asthma 1 | 56

Tissue

Blood and immune system 6 | 16,909
Digestive Tract 6 | 17,369
Endocrine System 6 | 18,159
Female tissues 6 | 17,400
Male tissues 6 | 17,142
Nervous System 6 | 16,725
Skin and soft tissues 6 | 17,230
Liver and Pancreas 5 | 16,750
Respiratory system 5 | 16,393
Urinary Tract 5 | 16,678
Cardiovascular System 4 | 15,192

Target Family

Non-IDG 3 | 12,091
Enzyme 1 | 4,145
GPCR 1 | 408
Transporter 1 | 473

WikiPathways Pathway

Thyroxine (Thyroid Hormone) Pr... 6 | 6
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Thyrotropin receptor TSHR Tclin GPCR -3.03356 1166.1 550
Sodium/iodide cotransporter SLC5A5 Tbio Transporter -3.03414 1016.4 360
Thyroid peroxidase TPO Tclin Enzyme -2.83776 580.4 368
Glycoprotein hormones alpha chain CGA Tbio Non-IDG -2.62079 405.6 915
Thyroglobulin TG Tbio Non-IDG -3.88676 7423.9 1081
Pro-thyrotropin-releasing hormone TRH Tbio Non-IDG -3.25312 1828.2 102