Development Level

Tbio 20 | 11,445
Tchem 13 | 1,598
Tclin 3 | 613

IMPC Phenotype

embryonic lethality prior to t... 3 | 278
preweaning lethality, complete... 3 | 979
abnormal spleen morphology 2 | 55
anophthalmia 2 | 33
decreased circulating LDL chol... 2 | 38
decreased mean platelet volume 2 | 25
embryonic lethality prior to o... 2 | 239
enlarged spleen 2 | 41
increased circulating alkaline... 2 | 122
increased mean platelet volume 2 | 45
increased spleen weight 2 | 10
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal response to new envir... 1 | 10
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal thymus morphology 1 | 7
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased spleen weight 1 | 10
dilated heart left ventricle 1 | 11
enlarged heart 1 | 210
enlarged kidney 1 | 14
enlarged lymph nodes 1 | 37
enlarged thymus 1 | 5
impaired glucose tolerance 1 | 75
increased cardiac stroke volum... 1 | 1
increased circulating LDL chol... 1 | 13
increased circulating bilirubi... 1 | 16
increased circulating sodium l... 1 | 71
increased glycosylated hemoglo... 1 | 1
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased red blood cell distr... 1 | 34
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97

Disease

Carcinoma 24 | 11,493
ovarian cancer 20 | 8,520
osteosarcoma 17 | 7,950
glioblastoma 15 | 5,792
Cancer 14 | 2,499
medulloblastoma, large-cell 14 | 6,241
psoriasis 12 | 6,694
ependymoma 10 | 4,679
adult high grade glioma 9 | 3,801
lung cancer 9 | 4,740
Breast cancer 8 | 3,578
Pick disease 8 | 1,894
Renal Cell Carcinoma 8 | 214
atypical teratoid / rhabdoid tumor 8 | 5,112
group 4 medulloblastoma 8 | 1,855
subependymal giant cell astrocytoma 8 | 2,287
astrocytic glioma 7 | 2,597
group 3 medulloblastoma 7 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
malignant mesothelioma 7 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
Kidney cancer 6 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
oligodendroglioma 6 | 2,850
tuberculosis 6 | 2,010
Intellectual disability 5 | 1,016
Lymphangioleiomyomatosis 5 | 16
astrocytoma 5 | 1,146
diabetes mellitus 5 | 1,728
lung adenocarcinoma 5 | 2,716
progressive supranuclear palsy 5 | 676
Angiomyolipoma 4 | 18
Carcinoma, Hepatocellular 4 | 228
Cardiomegaly 4 | 116
Epilepsy 4 | 792
Kidney angiomyolipoma 4 | 8
Liver carcinoma 4 | 240
Obesity 4 | 678
Pancreatic Neuroendocrine Tumor 4 | 45
Schizophrenia 4 | 1,160
Wolff-Parkinson-White syndrome 4 | 19
adrenocortical carcinoma 4 | 1,428
colon cancer 4 | 1,478
cystic fibrosis 4 | 1,696
invasive ductal carcinoma 4 | 2,951
pituitary cancer 4 | 1,972
primitive neuroectodermal tumor 4 | 3,035
Alzheimer's disease 3 | 658
Angiomyolipoma of kidney 3 | 4
Astrocytoma, Pilocytic 3 | 3,081
Autistic Disorder 3 | 364
Bipolar Disorder 3 | 666
Cafe au lait spots, multiple 3 | 17
Carcinoma, Squamous Cell 3 | 110
Cardiomyopathies 3 | 110
Cerebrovascular accident 3 | 63
Cognitive delay 3 | 608
Dull intelligence 3 | 645
Fibrous skin tumor of tuberous sclerosis 3 | 18
Focal cortical dysplasia of Taylor 3 | 3
Gastrointestinal stromal tumor 3 | 62
Global developmental delay 3 | 608
Heart disease 3 | 306
Hypothyroidism 3 | 122
Inflammation 3 | 120
Kidney disease 3 | 430
Low intelligence 3 | 645
Mental Retardation 3 | 645
Mental and motor retardation 3 | 608
Mental deficiency 3 | 645
Multiple myeloma 3 | 1,332
Multiple, subcutaneous nodules 3 | 53
Muscular atrophy 3 | 71
Papule 3 | 43
Parkinson's disease 3 | 392
Poor school performance 3 | 645
Precancerous Conditions 3 | 80
Rheumatoid arthritis 3 | 1,191
Sebaceous adenoma 3 | 26
Seizures 3 | 596
Skin tag 3 | 14
Squamous cell carcinoma 3 | 129
Stomach Neoplasms 3 | 300
Subcutaneous nodule 3 | 53
Tuberous sclerosis 3 | 19
Vascular disease 3 | 319
ductal carcinoma in situ 3 | 1,745
gastric cancer 3 | 459
hepatocellular carcinoma 3 | 547
juvenile dermatomyositis 3 | 1,187
lung carcinoma 3 | 2,843
pancreatic cancer 3 | 2,398
pediatric high grade glioma 3 | 1,064
spina bifida 3 | 1,074
Adult onset 2 | 82
Impaired cognition 2 | 96
Isolated cases 2 | 72
Mental impairment 2 | 95
Specific learning disability 2 | 47

Tissue

Cardiovascular System 36 | 15,192
Digestive Tract 36 | 17,369
Endocrine System 36 | 18,159
Female tissues 36 | 17,400
Male tissues 36 | 17,142
Skin and soft tissues 36 | 17,230
Blood and immune system 35 | 16,909
Liver and Pancreas 35 | 16,750
Nervous System 35 | 16,725
Respiratory system 35 | 16,393
Urinary Tract 35 | 16,678

Target Family

Non-IDG 16 | 12,091
Kinase 11 | 634
Enzyme 9 | 4,145

WikiPathways Pathway

Target Of Rapamycin (TOR) Sign... 36 | 36
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA damage-inducible transcript 4 protein DDIT4 Tbio Non-IDG -2.11497 150.3 231
Rapamycin-insensitive companion of mTOR RICTOR Tbio Non-IDG -2.79454 597.0 440
Cell division control protein 42 homolog CDC42 Tchem Enzyme -3.37283 2188.5 380
Proline-rich protein 5 PRR5 Tbio Non-IDG -1.13287 3.70 143
Serine/threonine-protein kinase ULK2 ULK2 Tchem Kinase -1.20211 12.1 391
Ribosomal protein S6 kinase beta-1 RPS6KB1 Tchem Kinase -3.18361 0.00000 1818
Ras-related GTP-binding protein B RRAGB Tbio Non-IDG -1.40729 26.2 113
Proline-rich protein 5-like PRR5L Tbio Non-IDG -0.43264 3.33 54
Target of rapamycin complex 2 subunit MAPKAP1 MAPKAP1 Tbio Non-IDG -2.01676 101.3 244
Ras-related GTP-binding protein C RRAGC Tbio Non-IDG -1.45388 30.6 200