Development Level

Tchem 26 | 1,598
Tbio 11 | 11,445
Tclin 5 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 6 | 979
abnormal lens morphology 3 | 81
abnormal bone mineralization 2 | 38
cataract 2 | 92
embryonic lethality prior to t... 2 | 278
increased circulating alkaline... 2 | 122
increased circulating choleste... 2 | 66
increased total body fat amoun... 2 | 134
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal glucose homeostasis 1 | 4
abnormal head morphology 1 | 10
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal skin condition 1 | 6
abnormal startle reflex 1 | 15
cardiovascular system phenotyp... 1 | 36
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating LDL chol... 1 | 38
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased mean corpuscular hem... 1 | 31
decreased thermal nociceptive ... 1 | 2
embryonic growth retardation 1 | 106
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating free fat... 1 | 20
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
mammalian phenotype 1 | 17
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
small superior vagus ganglion 1 | 74
thrombocytosis 1 | 27

Disease

Cancer 35 | 2,499
Carcinoma 30 | 11,493
ovarian cancer 27 | 8,520
glioblastoma 24 | 5,792
psoriasis 24 | 6,694
osteosarcoma 20 | 7,950
lung cancer 19 | 4,740
Schizophrenia 17 | 1,160
diabetes mellitus 17 | 1,728
tuberculosis 16 | 2,010
atypical teratoid / rhabdoid tumor 15 | 5,112
ependymoma 14 | 4,679
Alzheimer's disease 13 | 658
Arthritis 13 | 290
Breast Neoplasms 13 | 445
Mammary Neoplasms 13 | 425
Obesity 13 | 678
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
Asthma 12 | 385
Vascular disease 12 | 319
Brain Ischemia 11 | 110
Inflammatory bowel disease 11 | 151
Kidney disease 11 | 430
Lung disease 11 | 142
subependymal giant cell astrocytoma 11 | 2,287
Bipolar Disorder 10 | 666
Cholestasis, Extrahepatic 10 | 25
Heart disease 10 | 306
Lung Neoplasms 10 | 232
Reperfusion Injury 10 | 86
Stomach Neoplasms 10 | 300
adult high grade glioma 10 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
malignant mesothelioma 10 | 3,232
non-small cell lung cancer 10 | 2,890
Astrocytoma, Pilocytic 9 | 3,081
Breast cancer 9 | 3,578
Hyperglycemia 9 | 137
Hypertension 9 | 396
Liver Cirrhosis, Experimental 9 | 769
Liver disease 9 | 237
Multiple myeloma 9 | 1,332
Neoplasm Invasiveness 9 | 161
Neoplasm Metastasis 9 | 168
Toxic encephalopathy 9 | 141
interstitial cystitis 9 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
lung carcinoma 9 | 2,843
Carcinoma, Hepatocellular 8 | 228
Hyperalgesia 8 | 83
Hypersensitivity reaction type II disease 8 | 253
Kidney cancer 8 | 2,613
Liver carcinoma 8 | 240
Multiple Sclerosis 8 | 540
Parkinson's disease 8 | 392
Pneumonia 8 | 174
Prostatic Neoplasms 8 | 495
cystic fibrosis 8 | 1,696
group 4 medulloblastoma 8 | 1,855
lung adenocarcinoma 8 | 2,716
Atherosclerosis 7 | 291
Brain Injuries 7 | 65
Brain disease 7 | 96
Carcinoma, Squamous Cell 7 | 110
Cardiomyopathies 7 | 110
Cell Transformation, Neoplastic 7 | 97
Depressive disorder 7 | 409
Diabetes Mellitus, Non-Insulin-Dependent 7 | 145
Disease Models, Animal 7 | 155
Eye disease 7 | 62
Heat Stroke 7 | 13
Hypertensive disease 7 | 292
Mental Depression 7 | 333
Neoplastic Cell Transformation 7 | 89
Rheumatoid arthritis 7 | 1,191
Squamous cell carcinoma 7 | 129
astrocytoma 7 | 1,146
invasive ductal carcinoma 7 | 2,951
medulloblastoma, large-cell 7 | 6,241
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
ulcerative colitis 7 | 1,819
Autosomal recessive predisposition 6 | 1,442
Colonic Neoplasms 6 | 142
Diabetes Mellitus, Type 2 6 | 142
Endometriosis 6 | 540
Muscular atrophy 6 | 71
Myocardial Infarction 6 | 151
Osteoporosis 6 | 363
Renal Cell Carcinoma 6 | 214
Waldenstrons macroglobulinemia 6 | 765
breast carcinoma 6 | 1,638
juvenile dermatomyositis 6 | 1,187
oligodendroglioma 6 | 2,850
pituitary cancer 6 | 1,972
primitive neuroectodermal tumor 6 | 3,035
Myocardial Ischemia 5 | 169
acute myeloid leukemia 5 | 783
colon cancer 5 | 1,478
esophageal adenocarcinoma 5 | 737
pancreatic cancer 5 | 2,398

Tissue

Blood and immune system 41 | 16,909
Digestive Tract 41 | 17,369
Endocrine System 41 | 18,159
Female tissues 41 | 17,400
Liver and Pancreas 41 | 16,750
Male tissues 41 | 17,142
Nervous System 41 | 16,725
Respiratory system 41 | 16,393
Skin and soft tissues 41 | 17,230
Urinary Tract 41 | 16,678
Cardiovascular System 40 | 15,192

Target Family

Non-IDG 16 | 12,091
Kinase 14 | 634
Enzyme 6 | 4,145
Transcription Factor 5 | 1,400
Epigenetic 1 | 242

WikiPathways Pathway

TNF related weak inducer of ap... 42 | 42
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tumor necrosis factor ligand superfamily member 12 TNFSF12 Tbio Non-IDG -2.49751 362.7 413
C-C motif chemokine 2 CCL2 Tchem Non-IDG -3.84820 7088.3 1260
E3 ubiquitin-protein ligase TRIM63 TRIM63 Tbio Enzyme -2.29530 189.7 264
Tumor necrosis factor receptor superfamily member 12A TNFRSF12A Tbio Non-IDG -2.13589 160.9 382
Caspase-7 CASP7 Tchem Enzyme -2.69052 418.1 800
TNF receptor-associated factor 5 TRAF5 Tbio Non-IDG -1.57449 33.9 177
Baculoviral IAP repeat-containing protein 3 BIRC3 Tchem Non-IDG -2.62553 373.2 500
Caspase-8 CASP8 Tchem Enzyme -3.54224 3121.4 1045
Baculoviral IAP repeat-containing protein 2 BIRC2 Tchem Non-IDG -2.53423 308.7 351
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.18822 1239.4 1248