Development Level

Tchem 53 | 1,598
Tbio 36 | 11,445
Tclin 3 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 10 | 979
abnormal lens morphology 3 | 81
embryonic lethality prior to t... 3 | 278
abnormal bone structure 2 | 187
absent vibrissae 2 | 12
cataract 2 | 92
decreased circulating amylase ... 2 | 28
decreased circulating creatini... 2 | 39
decreased circulating sodium l... 2 | 22
increased bone mineral content 2 | 108
increased circulating alkaline... 2 | 122
increased circulating free fat... 2 | 20
increased leukocyte cell numbe... 2 | 47
increased startle reflex 2 | 112
preweaning lethality, incomple... 2 | 499
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal retina morphology 1 | 71
abnormal skin condition 1 | 6
abnormal snout morphology 1 | 23
abnormal startle reflex 1 | 15
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased monocyte cell number 1 | 8
decreased thermal nociceptive ... 1 | 2
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
impaired righting response 1 | 26
increased basophil cell number 1 | 7
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased eosinophil cell numb... 1 | 11
increased grip strength 1 | 41
increased large unstained cell... 1 | 5
increased lean body mass 1 | 172
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased thermal nociceptive ... 1 | 9
male infertility 1 | 123
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
short tibia 1 | 97
small superior vagus ganglion 1 | 74
stereotypic behavior 1 | 3
tremors 1 | 39
trunk curl 1 | 16

Disease

Carcinoma 66 | 11,493
ovarian cancer 63 | 8,520
Cancer 60 | 2,499
psoriasis 47 | 6,694
osteosarcoma 46 | 7,950
glioblastoma 44 | 5,792
lung cancer 37 | 4,740
medulloblastoma, large-cell 35 | 6,241
atypical teratoid / rhabdoid tumor 30 | 5,112
adult high grade glioma 23 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 23 | 3,291
lung carcinoma 22 | 2,843
Kidney cancer 21 | 2,613
ependymoma 21 | 4,679
Breast cancer 20 | 3,578
malignant mesothelioma 20 | 3,232
tuberculosis 20 | 2,010
Astrocytoma, Pilocytic 19 | 3,081
Schizophrenia 19 | 1,160
diabetes mellitus 18 | 1,728
Multiple myeloma 17 | 1,332
Rheumatoid arthritis 17 | 1,191
group 3 medulloblastoma 17 | 4,104
non-small cell lung cancer 17 | 2,890
Breast Neoplasms 16 | 445
Mammary Neoplasms 16 | 425
subependymal giant cell astrocytoma 16 | 2,287
Stomach Neoplasms 15 | 300
Vascular disease 15 | 319
interstitial cystitis 15 | 2,312
lung adenocarcinoma 15 | 2,716
oligodendroglioma 15 | 2,850
Brain Ischemia 14 | 110
Lung Neoplasms 14 | 232
astrocytic glioma 14 | 2,597
group 4 medulloblastoma 14 | 1,855
pancreatic cancer 14 | 2,398
Asthma 13 | 385
Inflammatory bowel disease 13 | 151
Kidney disease 13 | 430
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
juvenile dermatomyositis 13 | 1,187
ulcerative colitis 13 | 1,819
Arthritis 12 | 290
Bipolar Disorder 12 | 666
Carcinoma, Hepatocellular 12 | 228
Liver carcinoma 12 | 240
Obesity 12 | 678
Prostatic Neoplasms 12 | 495
Toxic encephalopathy 12 | 141
spina bifida 12 | 1,074
Alzheimer's disease 11 | 658
Depressive disorder 11 | 409
Heart disease 11 | 306
Parkinson's disease 11 | 392
Short stature 11 | 531
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
Lung disease 10 | 142
adrenocortical carcinoma 10 | 1,428
cutaneous lupus erythematosus 10 | 1,057
dermatomyositis 10 | 966
esophageal adenocarcinoma 10 | 737
Autosomal recessive predisposition 9 | 1,442
Carcinoma, Squamous Cell 9 | 110
Crohn's disease 9 | 321
Cryptorchidism 9 | 296
Diabetes Mellitus, Non-Insulin-Dependent 9 | 145
Hyperalgesia 9 | 83
Hyperglycemia 9 | 137
Hypersensitivity reaction type II disease 9 | 253
Hypertension 9 | 396
Liver Cirrhosis, Experimental 9 | 769
Mental Depression 9 | 333
Neoplasm Metastasis 9 | 168
Pick disease 9 | 1,894
Reperfusion Injury 9 | 86
Seizures 9 | 596
Splenomegaly 9 | 190
Squamous cell carcinoma 9 | 129
acute myeloid leukemia 9 | 783
acute quadriplegic myopathy 9 | 1,158
cystic fibrosis 9 | 1,696
pituitary cancer 9 | 1,972
primitive neuroectodermal tumor 9 | 3,035
Acquired scoliosis 8 | 281
Atherosclerosis 8 | 291
Byzanthine arch palate 8 | 194
Curvature of spine 8 | 282
Diabetes Mellitus, Type 2 8 | 142
Epilepsy 8 | 792
Hypoplastic mandible condyle 8 | 275
Leukemia 8 | 104
Melanoma 8 | 711
Multiple Sclerosis 8 | 540
Neurodegenerative disease 8 | 414
astrocytoma 8 | 1,146
colon cancer 8 | 1,478
invasive ductal carcinoma 8 | 2,951
primary pancreatic ductal adenocarcinoma 8 | 1,109

Tissue

Blood and immune system 92 | 16,909
Digestive Tract 92 | 17,369
Endocrine System 92 | 18,159
Female tissues 92 | 17,400
Liver and Pancreas 92 | 16,750
Male tissues 92 | 17,142
Nervous System 92 | 16,725
Respiratory system 92 | 16,393
Skin and soft tissues 92 | 17,230
Urinary Tract 92 | 16,678
Cardiovascular System 89 | 15,192

Target Family

Non-IDG 35 | 12,091
Kinase 29 | 634
Enzyme 23 | 4,145
Transcription Factor 4 | 1,400
Epigenetic 1 | 242

WikiPathways Pathway

TNF alpha Signaling Pathway 92 | 92
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
MAP kinase-activating death domain protein MADD Tbio Enzyme -1.86555 79.6 121
Protein tyrosine phosphatase receptor type C-associated protein PTPRCAP Tbio Enzyme -1.00697 13.5 90
Mitogen-activated protein kinase kinase kinase kinase 2 MAP4K2 Tchem Kinase -1.60423 35.3 193
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Kinase suppressor of Ras 2 KSR2 Tbio Kinase -0.90433 8.77 280
C-C motif chemokine 2 CCL2 Tchem Non-IDG -3.84820 7088.3 1260
Caspase-9 CASP9 Tchem Enzyme -3.44725 2332.0 1313
Caspase-7 CASP7 Tchem Enzyme -2.69052 418.1 800