Development Level

Tchem 13 | 1,598
Tbio 12 | 11,445
Tclin 2 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal cecum morphology 1 | 7
abnormal cornea morphology 1 | 31
abnormal lens morphology 1 | 81
abnormal skin condition 1 | 6
decreased circulating amylase ... 1 | 28
decreased circulating sodium l... 1 | 22
decreased heart weight 1 | 27
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased thermal nociceptive ... 1 | 2
embryonic lethality prior to t... 1 | 278
enlarged cecum 1 | 5
enlarged uterus 1 | 11
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased eosinophil cell numb... 1 | 11
increased leukocyte cell numbe... 1 | 47
increased neutrophil cell numb... 1 | 46
increased thermal nociceptive ... 1 | 9
preweaning lethality, incomple... 1 | 499
small superior vagus ganglion 1 | 74

Disease

Carcinoma 19 | 11,493
Cancer 18 | 2,499
ovarian cancer 15 | 8,520
psoriasis 14 | 6,694
glioblastoma 13 | 5,792
lung cancer 13 | 4,740
osteosarcoma 11 | 7,950
medulloblastoma, large-cell 9 | 6,241
Arthritis 8 | 290
Asthma 8 | 385
Astrocytoma, Pilocytic 8 | 3,081
Influenza 8 | 142
Multiple Sclerosis 8 | 540
Reperfusion Injury 8 | 86
Rheumatoid arthritis 8 | 1,191
atypical teratoid / rhabdoid tumor 8 | 5,112
diabetes mellitus 8 | 1,728
malignant mesothelioma 8 | 3,232
tuberculosis 8 | 2,010
Hypersensitivity reaction type II disease 7 | 253
Inflammatory bowel disease 7 | 151
Pneumonia 7 | 174
adult high grade glioma 7 | 3,801
lung adenocarcinoma 7 | 2,716
lung carcinoma 7 | 2,843
Coronary artery disease 6 | 268
Hypertension 6 | 396
Immunologic Deficiency Syndromes 6 | 113
Inflammation 6 | 120
Keratitis 6 | 62
Malaria 6 | 160
Meningitis 6 | 67
Prostatic Neoplasms 6 | 495
cystic fibrosis 6 | 1,696
dermatomyositis 6 | 966
subependymal giant cell astrocytoma 6 | 2,287
Allergic hypersensitivity disease 5 | 126
Arthritis, Rheumatoid 5 | 174
Atherosclerosis 5 | 291
Breast Neoplasms 5 | 445
Carcinoma, Hepatocellular 5 | 228
Cholestasis, Extrahepatic 5 | 25
Liver carcinoma 5 | 240
Mammary Neoplasms 5 | 425
Obesity 5 | 678
Peritonitis 5 | 43
Schizophrenia 5 | 1,160
acute myeloid leukemia 5 | 783
acute quadriplegic myopathy 5 | 1,158
astrocytoma 5 | 1,146
ependymoma 5 | 4,679
interstitial cystitis 5 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
invasive ductal carcinoma 5 | 2,951
juvenile dermatomyositis 5 | 1,187
non-small cell lung cancer 5 | 2,890
pancreatic cancer 5 | 2,398
ulcerative colitis 5 | 1,819
Autosomal recessive predisposition 4 | 1,442
Bipolar Disorder 4 | 666
Brain Ischemia 4 | 110
Brain disease 4 | 96
Cell Transformation, Neoplastic 4 | 97
Cerebrovascular disease 4 | 238
Chorioamnionitis 4 | 14
Common cold 4 | 67
Depressive disorder 4 | 409
Dermatitis 4 | 157
Diarrhea 4 | 253
Fever 4 | 138
Gastritis 4 | 47
Heart disease 4 | 306
Hyperglycemia 4 | 137
Hypertensive disease 4 | 292
Hypohidrotic ectodermal dysplasia 4 | 15
Kidney cancer 4 | 2,613
Kidney disease 4 | 430
Leukopenia 4 | 72
Liver Cirrhosis, Experimental 4 | 769
Liver disease 4 | 237
Lung Neoplasms 4 | 232
Major Depressive Disorder 4 | 301
Mastitis 4 | 48
Neoplasm Invasiveness 4 | 161
Neoplastic Cell Transformation 4 | 89
Otitis Media 4 | 52
Pancreatitis 4 | 123
Perinatal necrotizing enterocolitis 4 | 21
Salmonellosis 4 | 42
Unipolar Depression 4 | 250
Uveitis 4 | 103
Vasculitis 4 | 80
colon cancer 4 | 1,478
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
periodontitis 4 | 293
pituitary cancer 4 | 1,972
Anemia 3 | 365
Cholestasis 3 | 155
Pancreatic Neoplasm 3 | 85
Pancreatic Neoplasms 3 | 85

Tissue

Blood and immune system 28 | 16,909
Digestive Tract 27 | 17,369
Endocrine System 27 | 18,159
Female tissues 27 | 17,400
Liver and Pancreas 27 | 16,750
Male tissues 27 | 17,142
Nervous System 27 | 16,725
Respiratory system 27 | 16,393
Skin and soft tissues 27 | 17,230
Urinary Tract 27 | 16,678
Cardiovascular System 26 | 15,192

Target Family

Non-IDG 12 | 12,091
Kinase 11 | 634
Transcription Factor 3 | 1,400
Enzyme 2 | 4,145

WikiPathways Pathway

TLR4 Signaling and Tolerance 28 | 28
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 INPP5D Tbio Enzyme -2.06945 104.7 374
Serine/threonine-protein kinase TBK1 TBK1 Tchem Kinase -2.76728 569.1 455
TNF receptor-associated factor 6 TRAF6 Tbio Non-IDG -2.74221 511.1 403
Receptor-interacting serine/threonine-protein kinase 1 RIPK1 Tchem Kinase -2.33991 211.8 375
Interleukin-1 receptor-associated kinase 3 IRAK3 Tchem Kinase -1.86631 84.0 427
Myeloid differentiation primary response protein MyD88 MYD88 Tbio Non-IDG -3.26747 1795.4 672
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
Interleukin-1 receptor-associated kinase 4 IRAK4 Tchem Kinase -2.28820 202.2 610
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TAB2 Tbio Enzyme -1.90517 75.2 151