Development Level

Tbio 88 | 11,445
Tchem 35 | 1,598
Tclin 9 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 9 | 979
preweaning lethality, incomple... 8 | 499
abnormal bone structure 5 | 187
abnormal behavior 4 | 298
abnormal heart morphology 4 | 162
abnormal retina morphology 4 | 71
decreased total body fat amoun... 4 | 207
enlarged heart 4 | 210
increased heart weight 4 | 62
abnormal lens morphology 3 | 81
decreased body length 3 | 101
decreased body weight 3 | 161
decreased bone mineral content 3 | 151
decreased lean body mass 3 | 135
enlarged kidney 3 | 14
increased bone mineral content 3 | 108
abnormal femur morphology 2 | 14
abnormal lung morphology 2 | 26
abnormal seminal vesicle morph... 2 | 114
abnormal testis morphology 2 | 43
cataract 2 | 92
decreased circulating glucose ... 2 | 126
decreased circulating insulin ... 2 | 76
decreased circulating serum al... 2 | 82
decreased startle reflex 2 | 75
embryonic lethality prior to t... 2 | 278
enlarged spleen 2 | 41
improved glucose tolerance 2 | 79
increased body length 2 | 32
increased circulating choleste... 2 | 66
increased lean body mass 2 | 172
increased mean corpuscular vol... 2 | 92
increased neutrophil cell numb... 2 | 46
small testis 2 | 58
tremors 2 | 39
abnormal cranium morphology 1 | 36
abnormal epididymis morphology 1 | 42
abnormal esophagus morphology 1 | 5
abnormal eyelid morphology 1 | 7
abnormal gait 1 | 69
abnormal head size 1 | 6
abnormal iris morphology 1 | 13
abnormal kidney morphology 1 | 65
abnormal liver morphology 1 | 17
abnormal locomotor activation 1 | 16
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
abnormal tooth morphology 1 | 24
absent startle reflex 1 | 24
cardiovascular system phenotyp... 1 | 36
corneal opacity 1 | 32
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alkaline... 1 | 46
decreased circulating bilirubi... 1 | 19
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating fructosa... 1 | 30
decreased circulating total pr... 1 | 49
decreased fasted circulating g... 1 | 65
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lactate dehydrogenas... 1 | 16
decreased prepulse inhibition 1 | 82
decreased spleen weight 1 | 10
decreased vertical activity 1 | 208
dilated heart left ventricle 1 | 11
edema 1 | 59
embryonic lethality prior to o... 1 | 239
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
hypoactivity 1 | 132
increased B cell number 1 | 9
increased blood urea nitrogen ... 1 | 48
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating glycerol... 1 | 9
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased eosinophil cell numb... 1 | 11
increased hemoglobin content 1 | 45
increased large unstained cell... 1 | 5
increased or absent threshold ... 1 | 101
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
long tibia 1 | 25
persistence of hyaloid vascula... 1 | 33
premature death 1 | 5
short tibia 1 | 97
small seminal vesicle 1 | 10
trunk curl 1 | 16

Disease

Carcinoma 104 | 11,493
ovarian cancer 104 | 8,520
Cancer 87 | 2,499
osteosarcoma 84 | 7,950
glioblastoma 79 | 5,792
psoriasis 69 | 6,694
lung cancer 64 | 4,740
atypical teratoid / rhabdoid tumor 63 | 5,112
medulloblastoma, large-cell 63 | 6,241
Breast cancer 57 | 3,578
ependymoma 53 | 4,679
adult high grade glioma 45 | 3,801
Astrocytoma, Pilocytic 43 | 3,081
Kidney cancer 42 | 2,613
group 3 medulloblastoma 42 | 4,104
non-small cell lung cancer 42 | 2,890
pancreatic cancer 39 | 2,398
oligodendroglioma 38 | 2,850
subependymal giant cell astrocytoma 38 | 2,287
primitive neuroectodermal tumor 34 | 3,035
invasive ductal carcinoma 33 | 2,951
malignant mesothelioma 32 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 31 | 3,291
lung carcinoma 31 | 2,843
astrocytic glioma 28 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 28 | 2,955
lung adenocarcinoma 28 | 2,716
group 4 medulloblastoma 26 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 26 | 2,989
tuberculosis 26 | 2,010
ulcerative colitis 26 | 1,819
Multiple myeloma 25 | 1,332
Schizophrenia 25 | 1,160
juvenile dermatomyositis 25 | 1,187
Pick disease 24 | 1,894
breast carcinoma 24 | 1,638
diabetes mellitus 24 | 1,728
ductal carcinoma in situ 24 | 1,745
pituitary cancer 24 | 1,972
primary pancreatic ductal adenocarcinoma 24 | 1,109
Rheumatoid arthritis 22 | 1,191
astrocytoma 22 | 1,146
Liver Cirrhosis, Experimental 21 | 769
Vascular disease 20 | 319
Waldenstrons macroglobulinemia 20 | 765
colon cancer 20 | 1,478
cystic fibrosis 19 | 1,696
Intellectual disability 18 | 1,016
Lung Neoplasms 18 | 232
acute myeloid leukemia 18 | 783
acute quadriplegic myopathy 18 | 1,158
interstitial cystitis 18 | 2,312
Breast Neoplasms 17 | 445
Kidney disease 17 | 430
adrenocortical carcinoma 17 | 1,428
gastric cancer 17 | 459
Acquired scoliosis 16 | 281
Curvature of spine 16 | 282
Epilepsy 16 | 792
Mammary Neoplasms 16 | 425
Stomach Neoplasms 16 | 300
autosomal dominant Emery-Dreifuss muscular dystrophy 16 | 510
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,962
Arthritis 15 | 290
Neoplasm Invasiveness 15 | 161
Orbital separation excessive 15 | 244
Osteoporosis 15 | 363
Prostatic Neoplasms 15 | 495
dermatomyositis 15 | 966
Dull intelligence 14 | 645
Hypoplastic mandible condyle 14 | 275
Low intelligence 14 | 645
Mandibular hypoplasia 14 | 275
Mental Retardation 14 | 645
Mental deficiency 14 | 645
Micrognathism 14 | 275
Neoplasm Metastasis 14 | 168
Poor school performance 14 | 645
Short stature 14 | 531
hepatocellular carcinoma 14 | 547
pediatric high grade glioma 14 | 1,064
Byzanthine arch palate 13 | 194
Cell Transformation, Neoplastic 13 | 97
Squamous cell carcinoma 13 | 129
esophageal adenocarcinoma 13 | 737
nasopharyngeal carcinoma 13 | 1,058
Carcinoma, Hepatocellular 12 | 228
Carcinoma, Squamous Cell 12 | 110
Endometriosis 12 | 540
Heart disease 12 | 306
Liver carcinoma 12 | 240
Muscle hypotonia 12 | 571
Neoplastic Cell Transformation 12 | 89
Seizures 12 | 596
active Crohn's disease 12 | 922
Cognitive delay 11 | 608
Duchenne muscular dystrophy 11 | 601
Global developmental delay 11 | 608
Hypertensive disease 11 | 292
Mental and motor retardation 11 | 608

Tissue

Digestive Tract 132 | 17,369
Endocrine System 132 | 18,159
Blood and immune system 131 | 16,909
Liver and Pancreas 131 | 16,750
Male tissues 131 | 17,142
Skin and soft tissues 131 | 17,230
Female tissues 130 | 17,400
Nervous System 130 | 16,725
Respiratory system 130 | 16,393
Urinary Tract 130 | 16,678
Cardiovascular System 129 | 15,192

Target Family

Non-IDG 47 | 12,091
Transcription Factor 31 | 1,400
Kinase 27 | 634
Enzyme 24 | 4,145
Epigenetic 3 | 242

WikiPathways Pathway

TGF-beta Signaling Pathway 132 | 132
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Krueppel-like factor 6 KLF6 Tbio Transcription Factor -2.37304 253.6 161
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Fibronectin FN1 Tchem Non-IDG -3.09873 1208.8 1583
Rho-associated protein kinase 1 ROCK1 Tclin Kinase -2.64622 378.2 461
Macrophage metalloelastase MMP12 Tchem Enzyme 0.00000 447
Zinc finger E-box-binding homeobox 1 ZEB1 Tbio Transcription Factor -2.88752 659.2 460
Runt-related transcription factor 2 RUNX2 Tbio Transcription Factor -3.40091 2392.3 631
Transforming growth factor beta-1-induced transcript 1 protein TGFB1I1 Tbio Non-IDG -1.82580 89.7 147
Nuclear pore complex protein Nup214 NUP214 Tbio Non-IDG -2.25062 166.6 35
Cell division control protein 42 homolog CDC42 Tchem Enzyme -3.37283 2188.5 380