Development Level

Tbio 35 | 11,445
Tchem 16 | 1,598
Tclin 3 | 613

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal heart morphology 3 | 162
enlarged heart 3 | 210
abnormal gait 2 | 69
abnormal lung morphology 2 | 26
decreased lymphocyte cell numb... 2 | 83
embryonic lethality prior to t... 2 | 278
increased leukocyte cell numbe... 2 | 47
increased monocyte cell number 2 | 63
increased neutrophil cell numb... 2 | 46
preweaning lethality, incomple... 2 | 499
abnormal bone mineralization 1 | 38
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal head morphology 1 | 10
abnormal incisor morphology 1 | 4
abnormal liver morphology 1 | 17
abnormal locomotor behavior 1 | 24
abnormal radius morphology 1 | 8
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal snout morphology 1 | 23
abnormal startle reflex 1 | 15
abnormal tooth morphology 1 | 24
abnormal ulna morphology 1 | 8
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased thermal nociceptive ... 1 | 2
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
enlarged lymph nodes 1 | 37
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased circulating potassiu... 1 | 29
increased erythrocyte cell num... 1 | 39
increased hemoglobin content 1 | 45
increased lymphocyte cell numb... 1 | 32
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
mammalian phenotype 1 | 17
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87

Disease

Cancer 40 | 2,499
ovarian cancer 39 | 8,520
Carcinoma 38 | 11,493
psoriasis 34 | 6,694
glioblastoma 32 | 5,792
osteosarcoma 30 | 7,950
lung cancer 27 | 4,740
pancreatic cancer 25 | 2,398
atypical teratoid / rhabdoid tumor 24 | 5,112
Breast cancer 22 | 3,578
malignant mesothelioma 22 | 3,232
medulloblastoma, large-cell 21 | 6,241
intraductal papillary-mucinous adenoma (IPMA) 20 | 2,955
tuberculosis 20 | 2,010
adult high grade glioma 19 | 3,801
ependymoma 19 | 4,679
interstitial cystitis 19 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,291
Astrocytoma, Pilocytic 18 | 3,081
diabetes mellitus 18 | 1,728
cystic fibrosis 17 | 1,696
invasive ductal carcinoma 17 | 2,951
lung adenocarcinoma 17 | 2,716
lung carcinoma 17 | 2,843
Kidney disease 16 | 430
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
ulcerative colitis 16 | 1,819
Breast Neoplasms 15 | 445
Kidney cancer 15 | 2,613
Schizophrenia 15 | 1,160
group 4 medulloblastoma 15 | 1,855
non-small cell lung cancer 15 | 2,890
Mammary Neoplasms 14 | 425
pituitary cancer 14 | 1,972
ductal carcinoma in situ 13 | 1,745
Liver Cirrhosis, Experimental 12 | 769
acute quadriplegic myopathy 12 | 1,158
breast carcinoma 12 | 1,638
group 3 medulloblastoma 12 | 4,104
primary pancreatic ductal adenocarcinoma 12 | 1,109
Lung Neoplasms 11 | 232
Neoplasm Metastasis 11 | 168
Osteoporosis 11 | 363
Rheumatoid arthritis 11 | 1,191
Short stature 11 | 531
Stomach Neoplasms 11 | 300
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
primitive neuroectodermal tumor 11 | 3,035
subependymal giant cell astrocytoma 11 | 2,287
Acquired scoliosis 10 | 281
Carcinoma, Hepatocellular 10 | 228
Curvature of spine 10 | 282
Epilepsy 10 | 792
Heart disease 10 | 306
Inflammatory bowel disease 10 | 151
Intellectual disability 10 | 1,016
Liver disease 10 | 237
Muscle hypotonia 10 | 571
Obesity 10 | 678
Vascular disease 10 | 319
astrocytoma 10 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 10 | 510
colon cancer 10 | 1,478
Arthritis 9 | 290
Cleft Palate 9 | 271
Dull intelligence 9 | 645
Hypertension 9 | 396
Hypertensive disease 9 | 292
Liver carcinoma 9 | 240
Low intelligence 9 | 645
Lung disease 9 | 142
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Neoplasm Invasiveness 9 | 161
Orbital separation excessive 9 | 244
Pick disease 9 | 1,894
Poor school performance 9 | 645
Pulmonary Fibrosis 9 | 106
Seizures 9 | 596
gastric carcinoma 9 | 807
juvenile dermatomyositis 9 | 1,187
oligodendroglioma 9 | 2,850
sarcoidosis 9 | 370
Adenocarcinoma 8 | 122
Asthma 8 | 385
Autistic Disorder 8 | 364
Byzanthine arch palate 8 | 194
Cell Transformation, Neoplastic 8 | 97
Colonic Neoplasms 8 | 142
Colorectal Neoplasms 8 | 243
Coronary artery disease 8 | 268
Craniofacial Abnormalities 8 | 151
Disease Models, Animal 8 | 155
Hypoplastic mandible condyle 8 | 275
Liver Cirrhosis 8 | 181
Mandibular hypoplasia 8 | 275
Micrognathism 8 | 275
Pneumonia 8 | 174
Prostatic Neoplasms 8 | 495
Crohn's disease 7 | 321

Tissue

Digestive Tract 53 | 17,369
Endocrine System 53 | 18,159
Liver and Pancreas 53 | 16,750
Nervous System 53 | 16,725
Blood and immune system 52 | 16,909
Female tissues 52 | 17,400
Male tissues 52 | 17,142
Respiratory system 52 | 16,393
Skin and soft tissues 52 | 17,230
Urinary Tract 52 | 16,678
Cardiovascular System 50 | 15,192

Target Family

Non-IDG 24 | 12,091
Transcription Factor 21 | 1,400
Kinase 5 | 634
Enzyme 2 | 4,145
Epigenetic 2 | 242

WikiPathways Pathway

TGF-beta Receptor Signaling 54 | 54
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endoglin ENG Tbio Non-IDG -3.10482 1235.9 1622
Latent-transforming growth factor beta-binding protein 1 LTBP1 Tbio Non-IDG -1.97590 101.5 128
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
Mothers against decapentaplegic homolog 6 SMAD6 Tbio Transcription Factor -2.07569 106.7 450
Leukemia inhibitory factor LIF Tbio Non-IDG -2.86943 538.7 413
Runt-related transcription factor 2 RUNX2 Tbio Transcription Factor -3.40091 2392.3 631
Follistatin FST Tbio Non-IDG -3.07812 1179.4 356
Transforming growth factor beta receptor type 3 TGFBR3 Tbio Non-IDG -1.92250 80.6 270
Zinc finger E-box-binding homeobox 2 ZEB2 Tbio Transcription Factor -2.49656 262.6 474
Transcription factor E3 TFE3 Tbio Transcription Factor -2.43611 297.2 314