Development Level

Tbio 13 | 11,651
Tchem 5 | 1,388

IMPC Phenotype

preweaning lethality, complete... 2 | 979
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
increased blood uric acid leve... 1 | 5
increased body weight 1 | 25
increased circulating chloride... 1 | 41
increased granulocyte number 1 | 1
preweaning lethality, incomple... 1 | 499
small spleen 1 | 19

Disease

Carcinoma 16 | 11,493
Cancer 15 | 2,499
ovarian cancer 14 | 8,520
osteosarcoma 13 | 7,950
Astrocytoma, Pilocytic 9 | 3,081
Kidney cancer 9 | 2,613
Kidney disease 9 | 430
Neoplasm Invasiveness 9 | 161
ependymoma 9 | 4,679
glioblastoma 9 | 5,792
malignant mesothelioma 9 | 3,232
Breast cancer 8 | 3,578
Neoplasm Metastasis 8 | 168
atypical teratoid / rhabdoid tumor 8 | 5,112
lung cancer 8 | 4,740
Breast Neoplasms 7 | 445
Stomach Neoplasms 7 | 300
adult high grade glioma 7 | 3,801
diabetes mellitus 7 | 1,728
interstitial cystitis 7 | 2,312
lung carcinoma 7 | 2,843
ulcerative colitis 7 | 1,819
Mammary Neoplasms 6 | 425
cystic fibrosis 6 | 1,696
group 4 medulloblastoma 6 | 1,855
invasive ductal carcinoma 6 | 2,951
pancreatic cancer 6 | 2,398
psoriasis 6 | 6,694
Asthma 5 | 385
Carcinoma, Squamous Cell 5 | 110
Cell Transformation, Neoplastic 5 | 97
Congenital deafness 5 | 185
Deafness 5 | 198
Disease Models, Animal 5 | 155
Hearing Loss, Partial 5 | 185
Heart disease 5 | 306
Liver disease 5 | 237
Neoplastic Cell Transformation 5 | 89
Prostatic Neoplasms 5 | 495
Pulmonary Fibrosis 5 | 106
Renal Cell Carcinoma 5 | 214
Schizophrenia 5 | 1,160
Squamous cell carcinoma 5 | 129
Ureteral obstruction 5 | 33
Vascular disease 5 | 319
ductal carcinoma in situ 5 | 1,745
hearing impairment 5 | 199
juvenile dermatomyositis 5 | 1,187
non-small cell lung cancer 5 | 2,890
oligodendroglioma 5 | 2,850
primitive neuroectodermal tumor 5 | 3,035
subependymal giant cell astrocytoma 5 | 2,287
Acquired scoliosis 4 | 281
Arthritis 4 | 290
Bipolar Disorder 4 | 666
Colorectal Neoplasms 4 | 243
Craniofacial Abnormalities 4 | 151
Curvature of spine 4 | 282
Duchenne muscular dystrophy 4 | 601
Hypertensive disease 4 | 292
Inflammatory bowel disease 4 | 151
Liver Cirrhosis, Experimental 4 | 769
Liver Neoplasms, Experimental 4 | 59
Lung Neoplasms 4 | 232
Nerve Degeneration 4 | 121
Orbital separation excessive 4 | 244
Osteoarthritis 4 | 184
Osteoporosis 4 | 363
Ovarian Neoplasms 4 | 102
acute quadriplegic myopathy 4 | 1,158
breast carcinoma 4 | 1,638
gastric carcinoma 4 | 807
group 3 medulloblastoma 4 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
lung adenocarcinoma 4 | 2,716
medulloblastoma, large-cell 4 | 6,241
ovarian neoplasm 4 | 99
pituitary cancer 4 | 1,972
primary pancreatic ductal adenocarcinoma 4 | 1,109
Adenoma 3 | 167
Becker muscular dystrophy 3 | 191
Byzanthine arch palate 3 | 194
Cardiovascular system disease 3 | 246
Cocaine-Related Disorders 3 | 92
Degenerative polyarthritis 3 | 115
Depressive disorder 3 | 409
Endometrial cancer 3 | 311
Endometriosis 3 | 540
Hypertension 3 | 396
Liver Cirrhosis 3 | 181
Lung disease 3 | 142
Myopathy 3 | 185
Pancreatic Neoplasm 3 | 85
Pancreatic Neoplasms 3 | 85
Parkinson's disease 3 | 392
Skin cancer 3 | 469
adrenocortical carcinoma 3 | 1,428
astrocytic glioma 3 | 2,597
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
nephrosclerosis 3 | 333

Tissue

Cardiovascular System 18 | 15,192
Digestive Tract 18 | 17,369
Endocrine System 18 | 18,159
Female tissues 18 | 17,400
Liver and Pancreas 18 | 16,750
Male tissues 18 | 17,142
Nervous System 18 | 16,725
Respiratory system 18 | 16,393
Urinary Tract 18 | 16,678
Blood and immune system 17 | 16,909
Skin and soft tissues 17 | 17,230

Target Family

Non-IDG 8 | 12,091
Transcription Factor 7 | 1,400
Kinase 3 | 634

WikiPathways Pathway

TGF-B Signaling in Thyroid Cel... 18 | 18
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transforming growth factor beta-1 TGFB1 Tchem Non-IDG -3.84680 5672.0 1222
Mitogen-activated protein kinase 3 MAPK3 Tchem Kinase -3.66226 3484.0 1440
Mothers against decapentaplegic homolog 4 SMAD4 Tbio Transcription Factor -3.16129 1349.8 605
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.18822 1239.4 1248
Zinc finger protein SNAI1 SNAI1 Tbio Transcription Factor -3.28636 1782.9 566
Mothers against decapentaplegic homolog 3 SMAD3 Tbio Transcription Factor -3.19667 1403.6 1526
Cadherin-16 CDH16 Tbio Non-IDG -1.20184 12.6 247
Tenascin TNC Tbio Non-IDG -2.34421 216.5 642
Cadherin-1 CDH1 Tbio Non-IDG -3.85201 6324.3 1880
Runt-related transcription factor 2 RUNX2 Tbio Transcription Factor -3.40091 2392.3 631