Development Level

Tbio 41 | 11,651
Tchem 35 | 1,388
Tclin 14 | 612

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, complete... 7 | 979
preweaning lethality, incomple... 4 | 499
abnormal lens morphology 3 | 81
embryonic lethality prior to t... 3 | 278
abnormal bone structure 2 | 187
abnormal heart morphology 2 | 162
cataract 2 | 92
decreased body weight 2 | 161
decreased vertical activity 2 | 208
enlarged heart 2 | 210
increased circulating alkaline... 2 | 122
increased leukocyte cell numbe... 2 | 47
short tibia 2 | 97
abnormal behavior 1 | 298
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal gait 1 | 69
abnormal pancreas morphology 1 | 13
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal skin morphology 1 | 50
abnormal testis morphology 1 | 43
absent vibrissae 1 | 12
anophthalmia 1 | 33
decreased T cell number 1 | 15
decreased bone mineral content 1 | 151
decreased circulating amylase ... 1 | 28
decreased circulating creatini... 1 | 39
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased eosinophil cell numb... 1 | 24
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased monocyte cell number 1 | 8
decreased neutrophil cell numb... 1 | 42
decreased spleen weight 1 | 10
decreased thermal nociceptive ... 1 | 2
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged kidney 1 | 14
increased CD4-positive, alpha ... 1 | 4
increased blood urea nitrogen ... 1 | 48
increased blood uric acid leve... 1 | 5
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating chloride... 1 | 41
increased circulating free fat... 1 | 20
increased circulating triglyce... 1 | 42
increased granulocyte number 1 | 1
increased heart left ventricle... 1 | 4
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
increased thermal nociceptive ... 1 | 9
male infertility 1 | 123
small epididymis 1 | 3
small testis 1 | 58
tremors 1 | 39

Disease

Carcinoma 62 | 11,493
Cancer 60 | 2,499
lung cancer 48 | 4,740
osteosarcoma 48 | 7,950
ovarian cancer 48 | 8,520
psoriasis 40 | 6,694
glioblastoma 39 | 5,792
lung carcinoma 32 | 2,843
interstitial cystitis 30 | 2,312
ependymoma 26 | 4,679
atypical teratoid / rhabdoid tumor 24 | 5,112
cutaneous lupus erythematosus 24 | 1,057
medulloblastoma, large-cell 24 | 6,241
ulcerative colitis 24 | 1,819
Rheumatoid arthritis 23 | 1,191
malignant mesothelioma 23 | 3,232
Kidney cancer 22 | 2,613
Schizophrenia 21 | 1,160
subependymal giant cell astrocytoma 21 | 2,287
diabetes mellitus 20 | 1,728
oligodendroglioma 20 | 2,850
Arthritis 19 | 290
Breast cancer 19 | 3,578
group 3 medulloblastoma 19 | 4,104
tuberculosis 19 | 2,010
Astrocytoma, Pilocytic 18 | 3,081
adult high grade glioma 18 | 3,801
non-small cell lung cancer 18 | 2,890
Autosomal recessive predisposition 17 | 1,442
Immunologic Deficiency Syndromes 16 | 113
astrocytic glioma 16 | 2,597
pancreatic cancer 16 | 2,398
primitive neuroectodermal tumor 16 | 3,035
group 4 medulloblastoma 15 | 1,855
invasive ductal carcinoma 15 | 2,951
primary Sjogren syndrome 15 | 735
Lung Neoplasms 14 | 232
Pick disease 14 | 1,894
lung adenocarcinoma 14 | 2,716
Asthma 13 | 385
Hypersensitivity reaction type II disease 13 | 253
Liver Cirrhosis, Experimental 13 | 769
Lung disease 13 | 142
acute myeloid leukemia 13 | 783
astrocytoma 13 | 1,146
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
Alzheimer's disease 12 | 658
Bipolar Disorder 12 | 666
Breast Neoplasms 12 | 445
Mammary Neoplasms 12 | 425
cystic fibrosis 12 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
Alcoholic Intoxication, Chronic 11 | 289
Brain Ischemia 11 | 110
Cholestasis, Extrahepatic 11 | 25
Kidney disease 11 | 430
Multiple myeloma 11 | 1,332
Parkinson's disease 11 | 392
Seizures 11 | 596
Short stature 11 | 531
juvenile dermatomyositis 11 | 1,187
pituitary cancer 11 | 1,972
Cognitive delay 10 | 608
Depressive disorder 10 | 409
Fever 10 | 138
Global developmental delay 10 | 608
Hepatomegaly 10 | 285
Hyperalgesia 10 | 83
Hyperglycemia 10 | 137
Hypertension 10 | 396
Hypertensive disease 10 | 292
Inflammatory bowel disease 10 | 151
Intellectual disability 10 | 1,016
Liver disease 10 | 237
Mental and motor retardation 10 | 608
Obesity 10 | 678
Orbital separation excessive 10 | 244
Stomach Neoplasms 10 | 300
Vascular disease 10 | 319
primary pancreatic ductal adenocarcinoma 10 | 1,109
Acquired scoliosis 9 | 281
Arthritis, Rheumatoid 9 | 174
Curvature of spine 9 | 282
Dull intelligence 9 | 645
Epilepsy 9 | 792
Heart disease 9 | 306
Low intelligence 9 | 645
Mental Depression 9 | 333
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Multiple Sclerosis 9 | 540
Neoplasm Invasiveness 9 | 161
Poor school performance 9 | 645
Reperfusion Injury 9 | 86
Splenomegaly 9 | 190
Waldenstrons macroglobulinemia 9 | 765
breast carcinoma 9 | 1,638
colon cancer 9 | 1,478
dermatomyositis 9 | 966
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955

Tissue

Skin and soft tissues 90 | 17,230
Blood and immune system 89 | 16,909
Digestive Tract 89 | 17,369
Liver and Pancreas 89 | 16,750
Endocrine System 88 | 18,159
Female tissues 88 | 17,400
Male tissues 88 | 17,142
Respiratory system 88 | 16,393
Urinary Tract 88 | 16,678
Nervous System 86 | 16,725
Cardiovascular System 85 | 15,192

Target Family

Non-IDG 40 | 12,091
Kinase 26 | 634
Transcription Factor 11 | 1,400
Enzyme 10 | 4,145
GPCR 2 | 408
Ion Channel 1 | 344

WikiPathways Pathway

T-Cell antigen Receptor (TCR) ... 90 | 90
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interleukin-9 IL9 Tbio Non-IDG -2.50811 334.4 459
Tyrosine-protein kinase ZAP-70 ZAP70 Tchem Kinase -2.91589 798.2 1515
T-cell surface glycoprotein CD3 zeta chain CD247 Tbio Non-IDG -2.61157 386.3 882
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
E3 ubiquitin-protein ligase CBL-B CBLB Tbio Enzyme -0.82313 6.58 193
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075