Development Level

Tchem 15 | 1,598
Tclin 7 | 613
Tbio 5 | 11,445

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

increased leukocyte cell numbe... 2 | 47
preweaning lethality, complete... 2 | 979
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal skin condition 1 | 6
abnormal testis morphology 1 | 43
decreased T cell number 1 | 15
decreased body length 1 | 101
decreased body weight 1 | 161
decreased circulating amylase ... 1 | 28
decreased circulating glucose ... 1 | 126
decreased circulating glycerol... 1 | 16
decreased circulating magnesiu... 1 | 13
decreased circulating sodium l... 1 | 22
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased thermal nociceptive ... 1 | 2
decreased total body fat amoun... 1 | 207
embryonic lethality prior to o... 1 | 239
increased CD4-positive, alpha ... 1 | 4
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
small testis 1 | 58

Disease

Carcinoma 21 | 11,493
Cancer 19 | 2,499
ovarian cancer 18 | 8,520
lung cancer 17 | 4,740
osteosarcoma 16 | 7,950
psoriasis 15 | 6,694
glioblastoma 13 | 5,792
Kidney cancer 10 | 2,613
Breast cancer 9 | 3,578
Rheumatoid arthritis 9 | 1,191
Schizophrenia 9 | 1,160
interstitial cystitis 9 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
medulloblastoma, large-cell 8 | 6,241
non-small cell lung cancer 8 | 2,890
ulcerative colitis 8 | 1,819
Bipolar Disorder 7 | 666
diabetes mellitus 7 | 1,728
oligodendroglioma 7 | 2,850
primary Sjogren syndrome 7 | 735
tuberculosis 7 | 2,010
Adult T-Cell Lymphoma/Leukemia 6 | 30
Asthma 6 | 385
Leukemia-Lymphoma, Adult T-Cell 6 | 30
Pick disease 6 | 1,894
Splenomegaly 6 | 190
atypical teratoid / rhabdoid tumor 6 | 5,112
cutaneous lupus erythematosus 6 | 1,057
invasive ductal carcinoma 6 | 2,951
Alzheimer's disease 5 | 658
Atopic dermatitis 5 | 952
Autosomal recessive predisposition 5 | 1,442
Hypersensitivity reaction type II disease 5 | 253
Immunologic Deficiency Syndromes 5 | 113
Prostatic Neoplasms 5 | 495
adult high grade glioma 5 | 3,801
ependymoma 5 | 4,679
group 4 medulloblastoma 5 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
lung adenocarcinoma 5 | 2,716
lung carcinoma 5 | 2,843
sarcoidosis 5 | 370
subependymal giant cell astrocytoma 5 | 2,287
Autoimmune Diseases 4 | 67
Chronic Lymphocytic Leukemia 4 | 262
Common variable immunodeficiency 4 | 101
Diarrhea 4 | 253
Down syndrome 4 | 499
Fever 4 | 138
Hepatomegaly 4 | 285
Inflammatory bowel disease 4 | 151
Irregular hyperpigmentation 4 | 33
Lung disease 4 | 142
Lymphadenopathy 4 | 62
Lymphoproliferative syndrome 4 | 58
Melanoma 4 | 711
Pain 4 | 103
Palmoplantar keratosis 4 | 74
Recurrent respiratory infections 4 | 141
Renal Cell Carcinoma 4 | 214
Sezary Syndrome 4 | 27
Thyroiditis 4 | 29
Vascular disease 4 | 319
astrocytoma 4 | 1,146
cystic fibrosis 4 | 1,696
group 3 medulloblastoma 4 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
juvenile dermatomyositis 4 | 1,187
malignant mesothelioma 4 | 3,232
pancreatic cancer 4 | 2,398
primary pancreatic ductal adenocarcinoma 4 | 1,109
primitive neuroectodermal tumor 4 | 3,035
Anemia 3 | 365
Arthritis, Rheumatoid 3 | 174
Astrocytoma, Pilocytic 3 | 3,081
Autistic Disorder 3 | 364
Brain Ischemia 3 | 110
Breast Neoplasms 3 | 445
Depressive disorder 3 | 409
Endometrial cancer 3 | 311
Heart disease 3 | 306
Hypothyroidism 3 | 122
Infantile onset 3 | 238
Liver disease 3 | 237
Lung Neoplasms 3 | 232
Lymphedema 3 | 42
Lymphoma 3 | 81
Major Depressive Disorder 3 | 301
Mammary Neoplasms 3 | 425
Mood Disorders 3 | 184
Multiple Sclerosis 3 | 540
Parkinson's disease 3 | 392
Squamous cell carcinoma 3 | 129
Systemic lupus erythematosus 3 | 194
Waldenstrons macroglobulinemia 3 | 765
acute quadriplegic myopathy 3 | 1,158
adrenocortical carcinoma 3 | 1,428
astrocytic glioma 3 | 2,597
dermatomyositis 3 | 966
spina bifida 3 | 1,074

Tissue

Blood and immune system 27 | 16,909
Digestive Tract 27 | 17,369
Female tissues 27 | 17,400
Liver and Pancreas 27 | 16,750
Male tissues 27 | 17,142
Skin and soft tissues 27 | 17,230
Cardiovascular System 26 | 15,192
Endocrine System 26 | 18,159
Respiratory system 26 | 16,393
Urinary Tract 26 | 16,678
Nervous System 25 | 16,725

Target Family

Kinase 12 | 634
Non-IDG 8 | 12,091
Enzyme 5 | 4,145
Transcription Factor 2 | 1,400

WikiPathways Pathway

T-Cell Receptor and Co-stimula... 27 | 27
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity tyrosine-phosphorylation-regulated kinase 1A DYRK1A Tchem Kinase -2.68760 506.6 336
Nuclear factor of activated T-cells, cytoplasmic 2 NFATC2 Tbio Transcription Factor -2.43207 259.4 365
RAS guanyl-releasing protein 1 RASGRP1 Tchem Non-IDG -1.99263 105.6 99
Interleukin-2 IL2 Tchem Non-IDG -4.37903 24027.6 1518
T-cell surface glycoprotein CD8 alpha chain CD8A Tbio Non-IDG -2.37172 222.6 3514
Cytotoxic T-lymphocyte protein 4 CTLA4 Tclin Non-IDG -3.58565 3949.1 887
Glycogen synthase kinase-3 alpha GSK3A Tclin Kinase -1.82880 53.1 840
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -3.00390 610.8 955
NF-kappa-B inhibitor alpha NFKBIA Tchem Non-IDG -3.34987 1979.8 1300
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA Tchem Enzyme -3.00226 997.7 359