Development Level

Tbio 4 | 11,445
Tchem 1 | 1,598

Disease

Carcinoma 4 | 11,493
Autosomal recessive predisposition 3 | 1,442
colon cancer 3 | 1,478
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
psoriasis 3 | 6,694
Hypoglycemia 2 | 152
Ketoacidosis, episodic 2 | 4
Liver Cirrhosis, Experimental 2 | 769
Pick disease 2 | 1,894
Seizures 2 | 596
Vomiting 2 | 116
Waldenstrons macroglobulinemia 2 | 765
active Crohn's disease 2 | 922
active ulcerative colitis 2 | 764
adult high grade glioma 2 | 3,801
atypical teratoid / rhabdoid tumor 2 | 5,112
beta-ketothiolase deficiency 2 | 13
ependymoma 2 | 4,679
gastric carcinoma 2 | 807
glioblastoma 2 | 5,792
group 3 medulloblastoma 2 | 4,104
interstitial cystitis 2 | 2,312
lung carcinoma 2 | 2,843
malignant mesothelioma 2 | 3,232
medulloblastoma, large-cell 2 | 6,241
nephrosclerosis 2 | 333
ovarian cancer 2 | 8,520
primitive neuroectodermal tumor 2 | 3,035
3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 Deficiency 1 | 1
3-Methylcrotonyl-CoA carboxylase deficiency 1 | 11
3-methylglutaconic aciduria 1 | 29
3-methylglutaconicaciduria 1 | 1
Alpha-Methylacetoacetic Aciduria 1 | 1
Argininosuccinic aciduria 1 | 17
Astrocytoma, Pilocytic 1 | 3,081
Beta ketothiolase deficiency 1 | 1
Breast cancer 1 | 3,578
Carnitine deficiency 1 | 6
Chemical and Drug Induced Liver Injury 1 | 195
Chromosome 3q29 microdeletion syndrome 1 | 11
Chromosome 3q29 microduplication syndrome 1 | 6
Colonic Neoplasms 1 | 142
Comatose 1 | 56
Death in childhood 1 | 14
Deficiency of acetyl-CoA acetyltransferase 1 | 1
Dehydration 1 | 40
Dull intelligence 1 | 645
Epilepsy 1 | 792
Fever 1 | 138
Gastric antral vascular ectasia 1 | 10
Gaucher's disease 1 | 26
Glutaric aciduria 1 | 5
HMG CoA lyase deficiency 1 | 1
Hepatomegaly 1 | 285
Hydroxymethylglutaric aciduria 1 | 1
Hyperammonemia 1 | 30
Hyperargininemia 1 | 8
Intellectual disability 1 | 1,016
Isovaleric acidemia 1 | 15
Ketonuria 1 | 8
Kidney Failure, Chronic 1 | 46
Low intelligence 1 | 645
Maple syrup urine disease 1 | 24
Medium chain acyl-CoA dehydrogenase deficiency 1 | 13
Mental Retardation 1 | 645
Mental deficiency 1 | 645
Metabolic acidosis 1 | 90
Methylmalonic acidemia 1 | 37
Mouth Neoplasms 1 | 55
Multiple carboxylase deficiency 1 | 7
Multiple myeloma 1 | 1,332
Myocardial Ischemia 1 | 169
Neoplasm Invasiveness 1 | 161
Osteoporosis 1 | 363
Poor school performance 1 | 645
Propionic acidemia 1 | 16
Recurrence 1 | 33
Reye syndrome 1 | 11
Short chain acyl-CoA dehydrogenase deficiency 1 | 9
Somnolence 1 | 15
Tachypnea 1 | 20
Very long chain acyl-CoA dehydrogenase deficiency 1 | 10
adrenocortical carcinoma 1 | 1,428
astrocytic glioma 1 | 2,597
diabetes mellitus 1 | 1,728
ductal carcinoma in situ 1 | 1,745
esophageal adenocarcinoma 1 | 737
fibroadenoma 1 | 559
invasive ductal carcinoma 1 | 2,951
lung adenocarcinoma 1 | 2,716
mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency 1 | 1
non-small cell lung cancer 1 | 2,890
oligodendroglioma 1 | 2,850
osteosarcoma 1 | 7,950
pancreatic cancer 1 | 2,398
subependymal giant cell astrocytoma 1 | 2,287
ulcerative colitis 1 | 1,819

Tissue

Blood and immune system 5 | 16,909
Cardiovascular System 5 | 15,192
Digestive Tract 5 | 17,369
Endocrine System 5 | 18,159
Female tissues 5 | 17,400
Liver and Pancreas 5 | 16,750
Male tissues 5 | 17,142
Nervous System 5 | 16,725
Respiratory system 5 | 16,393
Skin and soft tissues 5 | 17,230
Urinary Tract 5 | 16,678

Target Family

Enzyme 5 | 4,145

WikiPathways Pathway

Synthesis and Degradation of K... 5 | 5
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

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