Development Level

Tbio 39 | 11,445
Tchem 7 | 1,598
Tclin 4 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 7 | 979
embryonic lethality prior to t... 4 | 278
embryonic lethality prior to o... 3 | 239
preweaning lethality, incomple... 3 | 499
decreased total body fat amoun... 2 | 207
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal cecum morphology 1 | 7
abnormal coat- hair morphology 1 | 19
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal heart shape 1 | 5
abnormal seminal vesicle morph... 1 | 114
abnormal testis morphology 1 | 43
abnormal vitreous body morphol... 1 | 10
absent pinna reflex 1 | 23
convulsive seizures 1 | 13
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating chloride... 1 | 30
decreased circulating iron lev... 1 | 32
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
enlarged cecum 1 | 5
enlarged heart 1 | 210
enlarged seminal vesicle 1 | 10
hydrometra 1 | 53
hyperactivity 1 | 148
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating free fat... 1 | 20
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased erythrocyte cell num... 1 | 39
increased grip strength 1 | 41
increased heart weight 1 | 62
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased total body fat amoun... 1 | 134
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
small superior vagus ganglion 1 | 74
small testis 1 | 58

Disease

Carcinoma 36 | 11,493
ependymoma 29 | 4,679
glioblastoma 29 | 5,792
atypical teratoid / rhabdoid tumor 27 | 5,112
oligodendroglioma 27 | 2,850
Astrocytoma, Pilocytic 25 | 3,081
adult high grade glioma 25 | 3,801
medulloblastoma, large-cell 25 | 6,241
group 3 medulloblastoma 24 | 4,104
astrocytic glioma 23 | 2,597
Pick disease 22 | 1,894
lung carcinoma 22 | 2,843
primitive neuroectodermal tumor 21 | 3,035
psoriasis 21 | 6,694
subependymal giant cell astrocytoma 21 | 2,287
Schizophrenia 20 | 1,160
ovarian cancer 20 | 8,520
lung cancer 17 | 4,740
Bipolar Disorder 16 | 666
Kidney cancer 16 | 2,613
osteosarcoma 14 | 7,950
Parkinson's disease 13 | 392
Epilepsy 12 | 792
malignant mesothelioma 12 | 3,232
Alzheimer's disease 11 | 658
invasive ductal carcinoma 11 | 2,951
pituitary cancer 10 | 1,972
Breast cancer 8 | 3,578
Depressive disorder 8 | 409
Intellectual disability 8 | 1,016
Seizures 8 | 596
ductal carcinoma in situ 8 | 1,745
non-small cell lung cancer 8 | 2,890
Mental Depression 7 | 333
Neurodegenerative disease 6 | 414
Tetanus 6 | 68
Toxic encephalopathy 6 | 141
acute quadriplegic myopathy 6 | 1,158
lung adenocarcinoma 6 | 2,716
Attention deficit hyperactivity disorder 5 | 278
Autistic Disorder 5 | 364
Blepharoptosis 5 | 231
Cerebellar Ataxia 5 | 304
Multiple myeloma 5 | 1,332
Psychotic Disorders 5 | 151
Rheumatoid arthritis 5 | 1,191
active Crohn's disease 5 | 922
colon cancer 5 | 1,478
Autosomal recessive predisposition 4 | 1,442
Botulism 4 | 24
Brain disease 4 | 96
Cataract 8 multiple types 4 | 33
Cocaine Dependence 4 | 51
Cognitive delay 4 | 608
Dementia 4 | 175
Diarrhea 4 | 253
Dull intelligence 4 | 645
Dysarthria 4 | 192
Global developmental delay 4 | 608
Low intelligence 4 | 645
Memory Disorders 4 | 40
Mental Retardation 4 | 645
Mental and motor retardation 4 | 608
Mental deficiency 4 | 645
Muscle hypotonia 4 | 571
Nystagmus 4 | 317
Obesity 4 | 678
Poor school performance 4 | 645
Reduced fetal movement 4 | 51
Slow progression 4 | 89
Tonic - clonic seizures 4 | 44
active ulcerative colitis 4 | 764
cystic fibrosis 4 | 1,696
diabetes mellitus 4 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
non primary Sjogren syndrome sicca 4 | 891
tuberculosis 4 | 2,010
Absent reflex 3 | 92
Developmental regression 3 | 95
Dystonia 3 | 164
Huntington's disease 3 | 76
Liver cancer 3 | 604
Loss of developmental milestones 3 | 95
Major Depressive Disorder 3 | 301
Mental deterioration in childhood 3 | 95
Migraine 3 | 83
Neurodevelopmental regression 3 | 95
Neuropathy 3 | 261
Psychomotor regression 3 | 95
Psychomotor regression beginning in infancy 3 | 95
Psychomotor regression in infants 3 | 95
Psychomotor regression, progressive 3 | 95
Unipolar Depression 3 | 250
adrenocortical carcinoma 3 | 1,428
breast carcinoma 3 | 1,638
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
pancreatic cancer 3 | 2,398
spina bifida 3 | 1,074

Tissue

Endocrine System 49 | 18,159
Digestive Tract 48 | 17,369
Female tissues 48 | 17,400
Nervous System 48 | 16,725
Skin and soft tissues 48 | 17,230
Blood and immune system 46 | 16,909
Male tissues 46 | 17,142
Liver and Pancreas 45 | 16,750
Urinary Tract 45 | 16,678
Respiratory system 44 | 16,393
Cardiovascular System 41 | 15,192

Target Family

Non-IDG 33 | 12,091
Transporter 13 | 473
Enzyme 3 | 4,145
Ion Channel 2 | 344

WikiPathways Pathway

Synaptic Vesicle Pathway 51 | 51
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Alpha-soluble NSF attachment protein NAPA Tbio Non-IDG -1.91664 86.4 148
Clathrin heavy chain 2 CLTCL1 Tbio Non-IDG -1.29555 21.3 39
Synapsin-1 SYN1 Tbio Non-IDG -2.86836 712.4 770
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.07841 114.8 103
Clathrin heavy chain 1 CLTC Tbio Non-IDG -1.66258 38.8 231
Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B Tclin Ion Channel -2.24422 170.7 75
Sodium/potassium-transporting ATPase subunit alpha-2 ATP1A2 Tclin Transporter -2.12480 136.2 116
Protein unc-13 homolog A UNC13A Tbio Non-IDG -1.84052 68.3 23
Protein unc-13 homolog C UNC13C Tdark Non-IDG -0.85788 5.65 19
Protein CLN8 CLN8 Tbio Non-IDG -1.61744 37.6 96