Development Level

Tbio 78 | 11,178
Tchem 44 | 1,885
Tclin 35 | 612

Collection

Ion Channel: IDG Consortium (T... 1 | 99
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 10 | 979
preweaning lethality, incomple... 8 | 499
embryonic lethality prior to t... 4 | 278
increased circulating alkaline... 4 | 122
decreased body length 3 | 101
hyperactivity 3 | 148
increased bone mineral density 3 | 72
increased hemoglobin content 3 | 45
increased total body fat amoun... 3 | 134
abnormal behavioral response t... 2 | 66
abnormal bone structure 2 | 187
abnormal embryo size 2 | 220
abnormal epididymis morphology 2 | 42
abnormal head morphology 2 | 10
abnormal retinal blood vessel ... 2 | 26
abnormal startle reflex 2 | 15
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased circulating amylase ... 2 | 28
decreased circulating total pr... 2 | 49
decreased circulating triglyce... 2 | 79
decreased fasted circulating g... 2 | 65
decreased heart left ventricle... 2 | 28
decreased lean body mass 2 | 135
decreased neutrophil cell numb... 2 | 42
decreased vertical activity 2 | 208
embryonic growth retardation 2 | 106
enlarged heart 2 | 210
female infertility 2 | 60
improved glucose tolerance 2 | 79
increased circulating serum al... 2 | 22
increased circulating total pr... 2 | 28
increased heart weight 2 | 62
increased or absent threshold ... 2 | 101
increased startle reflex 2 | 112
mammalian phenotype 2 | 17
short tibia 2 | 97
thin ventricular wall 2 | 24
abnormal cornea morphology 1 | 31
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
abnormal rib morphology 1 | 10
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal sleep behavior 1 | 70
abnormal urinary bladder morph... 1 | 11
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
convulsive seizures 1 | 13
decreased IgG1 level 1 | 8
decreased anxiety-related resp... 1 | 12
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased heart rate 1 | 18
decreased hemoglobin content 1 | 68
decreased mean corpuscular hem... 1 | 31
decreased mean platelet volume 1 | 25
decreased prepulse inhibition 1 | 82
decreased threshold for audito... 1 | 26
edema 1 | 59
enlarged lymph nodes 1 | 37
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased body temperature 1 | 9
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating fructosa... 1 | 13
increased circulating iron lev... 1 | 30
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased vertical activity 1 | 24
lordosis 1 | 1
male infertility 1 | 123
prenatal lethality prior to he... 1 | 87
tremors 1 | 39
vertebral transformation 1 | 12

Disease

Carcinoma 111 | 11,192
medulloblastoma, large-cell 81 | 6,086
glioblastoma 78 | 5,635
psoriasis 75 | 6,514
atypical teratoid / rhabdoid tumor 73 | 4,971
osteosarcoma 73 | 7,766
Schizophrenia 71 | 1,136
ovarian cancer 71 | 8,297
ependymoma 66 | 4,559
Cancer 65 | 2,388
lung cancer 63 | 4,607
adult high grade glioma 55 | 3,701
group 3 medulloblastoma 52 | 4,002
primitive neuroectodermal tumor 50 | 2,957
Bipolar Disorder 49 | 646
oligodendroglioma 49 | 2,768
Astrocytoma, Pilocytic 46 | 3,006
Depressive disorder 42 | 401
Breast cancer 41 | 3,469
Mental Depression 38 | 325
lung carcinoma 38 | 2,755
malignant mesothelioma 38 | 3,135
intraductal papillary-mucinous neoplasm (IPMN) 37 | 3,204
lung adenocarcinoma 37 | 2,627
diabetes mellitus 36 | 1,683
intraductal papillary-mucinous adenoma (IPMA) 36 | 2,872
Major Depressive Disorder 34 | 293
Parkinson's disease 34 | 378
pituitary cancer 34 | 1,915
ulcerative colitis 34 | 1,765
Epilepsy 33 | 775
astrocytic glioma 33 | 2,530
pancreatic cancer 32 | 2,322
Autistic Disorder 31 | 358
colon cancer 31 | 1,428
intraductal papillary-mucinous carcinoma (IPMC) 31 | 2,902
subependymal giant cell astrocytoma 31 | 2,230
Obesity 30 | 655
interstitial cystitis 30 | 2,237
non-small cell lung cancer 30 | 2,799
Alcoholic Intoxication, Chronic 29 | 283
Unipolar Depression 29 | 244
invasive ductal carcinoma 29 | 2,867
Alzheimer's disease 28 | 640
Seizures 28 | 584
Mood Disorders 27 | 181
Autosomal recessive predisposition 26 | 1,407
group 4 medulloblastoma 25 | 1,806
Intellectual disability 24 | 998
Pick disease 23 | 1,856
breast carcinoma 23 | 1,589
ductal carcinoma in situ 23 | 1,686
tuberculosis 23 | 1,963
astrocytoma 22 | 1,113
cystic fibrosis 22 | 1,629
Cognitive delay 21 | 596
Global developmental delay 21 | 596
Hypertension 21 | 372
Mental and motor retardation 21 | 596
Rheumatoid arthritis 21 | 1,156
Sudden infant death syndrome 21 | 31
Asthma 20 | 370
Diarrhea 20 | 245
Kidney cancer 20 | 2,548
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,911
Cerebrovascular disease 18 | 223
Inflammation 18 | 116
Kidney disease 18 | 411
Multiple myeloma 18 | 1,296
Muscle hypotonia 18 | 562
Toxic encephalopathy 18 | 139
Attention deficit hyperactivity disorder 17 | 272
Breast Neoplasms 17 | 423
Dementia 17 | 172
Dull intelligence 17 | 634
Heart disease 17 | 288
Inflammatory bowel disease 17 | 148
Low intelligence 17 | 634
Mental Retardation 17 | 634
Mental deficiency 17 | 634
Multiple Sclerosis 17 | 527
Poor school performance 17 | 634
adrenocortical carcinoma 17 | 1,385
pediatric high grade glioma 17 | 1,035
primary pancreatic ductal adenocarcinoma 17 | 1,071
Alcohol dependence 16 | 107
Down syndrome 16 | 480
Heart failure 16 | 157
Hyperglycemia 16 | 134
Hypertensive disease 16 | 278
Mammary Neoplasms 16 | 403
Neuropathy 16 | 254
Prostatic Neoplasms 16 | 472
Status Epilepticus 16 | 96
acute quadriplegic myopathy 16 | 1,133
Arthritis 15 | 276
Endometriosis 15 | 521
Psychotic Disorders 15 | 150
Waldenstrons macroglobulinemia 15 | 742
cutaneous lupus erythematosus 14 | 1,016

Tissue

Endocrine System 155 | 18,159
Digestive Tract 149 | 17,369
Nervous System 148 | 16,725
Skin and soft tissues 148 | 17,230
Female tissues 146 | 17,400
Liver and Pancreas 145 | 16,750
Blood and immune system 144 | 16,909
Male tissues 144 | 17,142
Urinary Tract 144 | 16,678
Respiratory system 136 | 16,393
Cardiovascular System 130 | 15,192

Target Family

Transcription Factor 47 | 1,400
Non-IDG 45 | 12,091
Enzyme 23 | 4,145
Ion Channel 14 | 344
GPCR 9 | 408
Kinase 5 | 634
Nuclear Receptor 5 | 48
Transporter 5 | 473
Epigenetic 4 | 242

WikiPathways Pathway

Sudden Infant Death Syndrome (... 157 | 157
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Homeobox protein NANOG NANOG Tchem Transcription Factor -2.94914 1130.5 958
Homeobox protein Nkx-2.2 NKX2-2 Tbio Transcription Factor -2.06202 108.0 379
BDNF/NT-3 growth factors receptor NTRK2 Tchem Kinase -3.14477 1170.3 947
Excitatory amino acid transporter 1 SLC1A3 Tchem Transporter -2.76402 569.7 221
Aquaporin-4 AQP4 Tchem Non-IDG -3.33435 2159.1 358
Cell division cycle-associated 7-like protein CDCA7L Tbio Non-IDG -1.12641 11.2 146
Homeobox protein engrailed-1 EN1 Tbio Transcription Factor -2.44551 264.6 188
ATP-sensitive inward rectifier potassium channel 8 KCNJ8 Tbio Ion Channel -2.31405 197.3 142
5-hydroxytryptamine receptor 1A HTR1A Tclin GPCR -3.67718 4891.4 254
Glycerol-3-phosphate dehydrogenase 1-like protein GPD1L Tbio Enzyme -1.31283 20.2 132