Development Level

Tbio 88 | 11,651
Tclin 35 | 612
Tchem 34 | 1,388

Collection

RFA-RM-18-021 2 | 328
Ion Channel: IDG Consortium (T... 1 | 99
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 10 | 979
preweaning lethality, incomple... 8 | 499
embryonic lethality prior to t... 4 | 278
increased circulating alkaline... 4 | 122
decreased body length 3 | 101
hyperactivity 3 | 148
increased bone mineral density 3 | 72
increased hemoglobin content 3 | 45
increased total body fat amoun... 3 | 134
abnormal behavioral response t... 2 | 66
abnormal bone structure 2 | 187
abnormal embryo size 2 | 220
abnormal epididymis morphology 2 | 42
abnormal head morphology 2 | 10
abnormal retinal blood vessel ... 2 | 26
abnormal startle reflex 2 | 15
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased circulating amylase ... 2 | 28
decreased circulating total pr... 2 | 49
decreased circulating triglyce... 2 | 79
decreased fasted circulating g... 2 | 65
decreased heart left ventricle... 2 | 28
decreased lean body mass 2 | 135
decreased neutrophil cell numb... 2 | 42
decreased vertical activity 2 | 208
embryonic growth retardation 2 | 106
enlarged heart 2 | 210
female infertility 2 | 60
improved glucose tolerance 2 | 79
increased circulating serum al... 2 | 22
increased circulating total pr... 2 | 28
increased heart weight 2 | 62
increased or absent threshold ... 2 | 101
increased startle reflex 2 | 112
mammalian phenotype 2 | 17
short tibia 2 | 97
thin ventricular wall 2 | 24
abnormal cornea morphology 1 | 31
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
abnormal rib morphology 1 | 10
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal sleep behavior 1 | 70
abnormal urinary bladder morph... 1 | 11
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
convulsive seizures 1 | 13
decreased IgG1 level 1 | 8
decreased anxiety-related resp... 1 | 12
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased heart rate 1 | 18
decreased hemoglobin content 1 | 68
decreased mean corpuscular hem... 1 | 31
decreased mean platelet volume 1 | 25
decreased prepulse inhibition 1 | 82
decreased threshold for audito... 1 | 26
edema 1 | 59
enlarged lymph nodes 1 | 37
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased body temperature 1 | 9
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating fructosa... 1 | 13
increased circulating iron lev... 1 | 30
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased vertical activity 1 | 24
lordosis 1 | 1
male infertility 1 | 123
prenatal lethality prior to he... 1 | 87
tremors 1 | 39
vertebral transformation 1 | 12

Disease

Carcinoma 115 | 11,493
medulloblastoma, large-cell 86 | 6,241
glioblastoma 82 | 5,792
psoriasis 78 | 6,694
atypical teratoid / rhabdoid tumor 76 | 5,112
osteosarcoma 75 | 7,950
ovarian cancer 75 | 8,520
Schizophrenia 72 | 1,160
ependymoma 70 | 4,679
Cancer 67 | 2,499
lung cancer 67 | 4,740
adult high grade glioma 56 | 3,801
group 3 medulloblastoma 56 | 4,104
primitive neuroectodermal tumor 53 | 3,035
oligodendroglioma 52 | 2,850
Bipolar Disorder 50 | 666
Astrocytoma, Pilocytic 47 | 3,081
Breast cancer 42 | 3,578
Depressive disorder 42 | 409
lung carcinoma 40 | 2,843
malignant mesothelioma 40 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 39 | 3,291
Mental Depression 38 | 333
lung adenocarcinoma 38 | 2,716
diabetes mellitus 37 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 37 | 2,955
pituitary cancer 37 | 1,972
Epilepsy 35 | 792
Parkinson's disease 35 | 392
astrocytic glioma 35 | 2,597
Major Depressive Disorder 34 | 301
ulcerative colitis 34 | 1,819
intraductal papillary-mucinous carcinoma (IPMC) 33 | 2,989
pancreatic cancer 33 | 2,398
subependymal giant cell astrocytoma 33 | 2,287
Autistic Disorder 32 | 364
colon cancer 32 | 1,478
invasive ductal carcinoma 32 | 2,951
non-small cell lung cancer 32 | 2,890
interstitial cystitis 31 | 2,312
Obesity 30 | 678
Seizures 30 | 596
Alcoholic Intoxication, Chronic 29 | 289
Alzheimer's disease 29 | 658
Unipolar Depression 29 | 250
Mood Disorders 27 | 184
Autosomal recessive predisposition 26 | 1,442
group 4 medulloblastoma 26 | 1,855
Intellectual disability 25 | 1,016
tuberculosis 25 | 2,010
breast carcinoma 24 | 1,638
cystic fibrosis 24 | 1,696
ductal carcinoma in situ 24 | 1,745
Pick disease 23 | 1,894
astrocytoma 23 | 1,146
Cognitive delay 22 | 608
Global developmental delay 22 | 608
Hypertension 22 | 396
Mental and motor retardation 22 | 608
Kidney cancer 21 | 2,613
Rheumatoid arthritis 21 | 1,191
Sudden infant death syndrome 21 | 32
Asthma 20 | 385
Diarrhea 20 | 253
Muscle hypotonia 20 | 571
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,962
pediatric high grade glioma 19 | 1,064
Breast Neoplasms 18 | 445
Cerebrovascular disease 18 | 238
Inflammation 18 | 120
Kidney disease 18 | 430
Multiple myeloma 18 | 1,332
Toxic encephalopathy 18 | 141
acute quadriplegic myopathy 18 | 1,158
primary pancreatic ductal adenocarcinoma 18 | 1,109
Attention deficit hyperactivity disorder 17 | 278
Dementia 17 | 175
Dull intelligence 17 | 645
Heart disease 17 | 306
Hypertensive disease 17 | 292
Inflammatory bowel disease 17 | 151
Low intelligence 17 | 645
Mammary Neoplasms 17 | 425
Mental Retardation 17 | 645
Mental deficiency 17 | 645
Multiple Sclerosis 17 | 540
Poor school performance 17 | 645
Prostatic Neoplasms 17 | 495
Status Epilepticus 17 | 98
adrenocortical carcinoma 17 | 1,428
Alcohol dependence 16 | 107
Down syndrome 16 | 499
Heart failure 16 | 162
Hyperglycemia 16 | 137
Neuropathy 16 | 261
Waldenstrons macroglobulinemia 16 | 765
Arthritis 15 | 290
Endometriosis 15 | 540
Vascular disease 15 | 319
cutaneous lupus erythematosus 15 | 1,057

Tissue

Endocrine System 155 | 18,159
Digestive Tract 149 | 17,369
Nervous System 148 | 16,725
Skin and soft tissues 148 | 17,230
Female tissues 146 | 17,400
Liver and Pancreas 145 | 16,750
Blood and immune system 144 | 16,909
Male tissues 144 | 17,142
Urinary Tract 144 | 16,678
Respiratory system 136 | 16,393
Cardiovascular System 130 | 15,192

Target Family

Transcription Factor 47 | 1,400
Non-IDG 45 | 12,091
Enzyme 23 | 4,145
Ion Channel 14 | 344
GPCR 9 | 408
Kinase 5 | 634
Nuclear Receptor 5 | 48
Transporter 5 | 473
Epigenetic 4 | 242

WikiPathways Pathway

Sudden Infant Death Syndrome (... 157 | 157
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Transcription factor HES-1 HES1 Tbio Transcription Factor -1.77409 55.5 444
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075
Sodium-dependent serotonin transporter SLC6A4 Tclin Transporter -3.63283 4453.8 245
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 GNB3 Tbio Non-IDG -2.34836 235.8 161
Runt-related transcription factor 3 RUNX3 Tbio Transcription Factor -2.71721 536.2 438
14-3-3 protein beta/alpha YWHAB Tchem Non-IDG -2.06798 109.1 482
Vasoactive intestinal polypeptide receptor 2 VIPR2 Tchem GPCR -2.20668 142.1 255
Pituitary adenylate cyclase-activating polypeptide type I receptor ADCYAP1R1 Tchem GPCR -1.98111 94.8 184
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.09531 11.7 331