Development Level

Tbio 37 | 11,651
Tclin 1 | 612

IMPC Phenotype

embryonic lethality prior to t... 3 | 278
increased circulating chloride... 2 | 41
preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal heart morphology 1 | 162
abnormal response to new envir... 1 | 10
abnormal skin morphology 1 | 50
decreased body weight 1 | 161
decreased circulating amylase ... 1 | 28
decreased mean corpuscular vol... 1 | 79
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
hyperactivity 1 | 148
increased blood uric acid leve... 1 | 5
increased circulating alkaline... 1 | 122
increased circulating iron lev... 1 | 30
increased granulocyte number 1 | 1
increased heart weight 1 | 62
increased startle reflex 1 | 112
long tibia 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
prolonged PR interval 1 | 15

Disease

Carcinoma 25 | 11,493
psoriasis 22 | 6,694
Hypertrophic Cardiomyopathy 17 | 117
acute quadriplegic myopathy 16 | 1,158
Cardiomyopathy, Dilated 15 | 83
Dilated cardiomyopathy 15 | 56
Cardiomyopathy 14 | 116
glioblastoma 14 | 5,792
Myopathy 13 | 185
atypical teratoid / rhabdoid tumor 13 | 5,112
lung cancer 13 | 4,740
ovarian cancer 13 | 8,520
Autosomal recessive predisposition 12 | 1,442
Breast cancer 12 | 3,578
Distal arthrogryposis 12 | 42
Familial isolated dilated cardiomyopathy 12 | 41
LEFT VENTRICULAR NONCOMPACTION 10 12 | 40
LEFT VENTRICULAR NONCOMPACTION 8 12 | 40
Duchenne muscular dystrophy 10 | 601
malignant mesothelioma 10 | 3,232
medulloblastoma, large-cell 10 | 6,241
osteosarcoma 10 | 7,950
Acquired scoliosis 9 | 281
Curvature of spine 9 | 282
colon cancer 9 | 1,478
group 3 medulloblastoma 9 | 4,104
lung adenocarcinoma 9 | 2,716
pancreatic cancer 9 | 2,398
Arthrogryposis 8 | 54
Congestive heart failure 8 | 113
Kidney cancer 8 | 2,613
ependymoma 8 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
invasive ductal carcinoma 8 | 2,951
primitive neuroectodermal tumor 8 | 3,035
Astrocytoma, Pilocytic 7 | 3,081
Becker muscular dystrophy 7 | 191
Byzanthine arch palate 7 | 194
Nemaline myopathy 7 | 17
diabetes mellitus 7 | 1,728
lung carcinoma 7 | 2,843
Amyotrophic lateral sclerosis 6 | 451
Bell Palsy 6 | 58
Blepharoptosis 6 | 231
Cardiomyopathy, Hypertrophic, Familial 6 | 9
Congenital clubfoot 6 | 109
Distal arthrogryposis syndrome 6 | 8
Facial Paresis 6 | 59
Facial muscle weakness of muscles innervated by CN VII 6 | 58
Heart failure 6 | 162
Left ventricular noncompaction 6 | 26
Liver Cirrhosis, Experimental 6 | 769
Narrow face 6 | 54
Primary cutaneous amyloidosis 6 | 29
Thin face 6 | 54
adult high grade glioma 6 | 3,801
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 510
breast carcinoma 6 | 1,638
cystic fibrosis 6 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
limb girdle muscular dystrophy 2A 6 | 213
non-small cell lung cancer 6 | 2,890
ARTHROGRYPOSIS, DISTAL, TYPE 1 5 | 6
Acute coronary syndrome 5 | 39
Adducted thumb 5 | 22
Bulbar palsy 5 | 19
Bulbar weakness 5 | 19
Cardiomyopathy, Hypertrophic 5 | 24
Cerebrovascular disease 5 | 238
Clubfoot 5 | 39
Deglutition Disorders 5 | 132
EMG: myopathic abnormalities 5 | 22
Feeding difficulties 5 | 127
Flexion contracture of proximal interphalangeal joint 5 | 75
Generalized muscle weakness 5 | 57
Heart disease 5 | 306
Hypoplastic mandible condyle 5 | 275
Joint stiffness 5 | 84
Long philtrum 5 | 137
Mandibular hypoplasia 5 | 275
Melanoma 5 | 711
Metatarsus Varus 5 | 24
Micrognathism 5 | 275
Motor delay 5 | 147
Muscle hypotonia 5 | 571
No development of motor milestones 5 | 147
Overlapping fingers 5 | 10
Proximal muscle weakness 5 | 47
Proximal neurogenic muscle weakness 5 | 47
Respiratory insufficiency due to muscle weakness 5 | 37
Short stature 5 | 531
Skin cancer 5 | 469
Talipes 5 | 20
Talipes foot deformities 5 | 20
Toeing-in 5 | 24
Ulnar deviation of the fingers 5 | 21
fibroadenoma 5 | 559
group 4 medulloblastoma 5 | 1,855
juvenile dermatomyositis 5 | 1,187

Tissue

Digestive Tract 38 | 17,369
Endocrine System 38 | 18,159
Male tissues 38 | 17,142
Skin and soft tissues 38 | 17,230
Urinary Tract 37 | 16,678
Blood and immune system 36 | 16,909
Cardiovascular System 36 | 15,192
Female tissues 35 | 17,400
Liver and Pancreas 35 | 16,750
Nervous System 34 | 16,725
Respiratory system 32 | 16,393

Target Family

Non-IDG 37 | 12,091
Kinase 1 | 634

WikiPathways Pathway

Striated Muscle Contraction 38 | 38
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tropomodulin-1 TMOD1 Tbio Non-IDG -1.84485 74.1 155
Myosin-binding protein C, slow-type MYBPC1 Tbio Non-IDG -1.29409 20.0 185
Troponin C, slow skeletal and cardiac muscles TNNC1 Tclin Non-IDG -1.15127 12.7 281
Myosin-binding protein C, cardiac-type MYBPC3 Tbio Non-IDG -2.45618 287.6 139
Troponin T, slow skeletal muscle TNNT1 Tbio Non-IDG -3.46905 2926.3 148
Troponin C, skeletal muscle TNNC2 Tbio Non-IDG -0.85050 6.68 102
Alpha-actinin-2 ACTN2 Tbio Non-IDG -1.89804 72.9 245
Tropomyosin alpha-1 chain TPM1 Tbio Non-IDG -2.19537 154.3 227
Actin, aortic smooth muscle ACTA2 Tbio Non-IDG -2.25358 161.4 773
Telethonin TCAP Tbio Non-IDG -3.33021 2076.3 97