Development Level

Tbio 36 | 11,445
Tchem 26 | 1,598
Tclin 6 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 8 | 979
decreased circulating LDL chol... 4 | 38
decreased total body fat amoun... 4 | 207
preweaning lethality, incomple... 4 | 499
decreased body weight 3 | 161
decreased circulating HDL chol... 3 | 68
decreased circulating choleste... 3 | 93
enlarged spleen 3 | 41
abnormal embryo size 2 | 220
abnormal embryo turning 2 | 31
abnormal heart morphology 2 | 162
abnormal lens morphology 2 | 81
abnormal retinal blood vessel ... 2 | 26
abnormal retinal vasculature m... 2 | 27
decreased body length 2 | 101
decreased circulating alanine ... 2 | 47
decreased circulating alkaline... 2 | 46
decreased circulating free fat... 2 | 31
decreased circulating total pr... 2 | 49
decreased erythrocyte cell num... 2 | 62
decreased mean platelet volume 2 | 25
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
impaired glucose tolerance 2 | 75
increased circulating choleste... 2 | 66
increased mean corpuscular hem... 2 | 96
increased mean platelet volume 2 | 45
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal heart left ventricle ... 1 | 16
abnormal liver morphology 1 | 17
abnormal neural tube closure 1 | 46
abnormal response to new envir... 1 | 10
abnormal skin condition 1 | 6
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal stomach morphology 1 | 10
abnormal thymus morphology 1 | 7
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased cardiac muscle contr... 1 | 11
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating glycerol... 1 | 16
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating unsatura... 1 | 2
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart rate 1 | 18
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged thymus 1 | 5
increased blood urea nitrogen ... 1 | 48
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased circulating free fat... 1 | 20
increased circulating fructosa... 1 | 13
increased circulating iron lev... 1 | 30
increased erythrocyte cell num... 1 | 39
increased glycosylated hemoglo... 1 | 1
increased hematocrit 1 | 46
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
increased total body fat amoun... 1 | 134
mammalian phenotype 1 | 17
prolonged PQ interval 1 | 5
prolonged QT interval 1 | 38

Disease

Carcinoma 52 | 11,493
ovarian cancer 46 | 8,520
osteosarcoma 42 | 7,950
psoriasis 36 | 6,694
medulloblastoma, large-cell 32 | 6,241
glioblastoma 27 | 5,792
Cancer 23 | 2,499
Breast cancer 22 | 3,578
Obesity 22 | 678
atypical teratoid / rhabdoid tumor 22 | 5,112
pancreatic ductal adenocarcinoma liver metastasis 21 | 1,962
Pick disease 20 | 1,894
diabetes mellitus 20 | 1,728
lung cancer 20 | 4,740
Kidney cancer 16 | 2,613
Carcinoma, Hepatocellular 15 | 228
Liver carcinoma 15 | 240
Schizophrenia 15 | 1,160
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
oligodendroglioma 15 | 2,850
Fatty liver disease 14 | 103
ductal carcinoma in situ 14 | 1,745
group 3 medulloblastoma 14 | 4,104
invasive ductal carcinoma 14 | 2,951
malignant mesothelioma 14 | 3,232
Alzheimer's disease 13 | 658
Autosomal recessive predisposition 13 | 1,442
Lipid metabolism disorder 13 | 114
lung adenocarcinoma 13 | 2,716
pituitary cancer 13 | 1,972
adult high grade glioma 12 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
Hyperglycemia 11 | 137
active Crohn's disease 11 | 922
ependymoma 11 | 4,679
group 4 medulloblastoma 11 | 1,855
interstitial cystitis 11 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
primitive neuroectodermal tumor 11 | 3,035
Atherosclerosis 10 | 291
active ulcerative colitis 10 | 764
astrocytoma 10 | 1,146
breast carcinoma 10 | 1,638
Intellectual disability 9 | 1,016
acute quadriplegic myopathy 9 | 1,158
astrocytic glioma 9 | 2,597
autosomal dominant Emery-Dreifuss muscular dystrophy 9 | 510
cystic fibrosis 9 | 1,696
lung carcinoma 9 | 2,843
pancreatic cancer 9 | 2,398
Heart failure 8 | 162
Liver Cirrhosis, Experimental 8 | 769
Multiple myeloma 8 | 1,332
Parkinson's disease 8 | 392
Waldenstrons macroglobulinemia 8 | 765
adrenocortical carcinoma 8 | 1,428
non-small cell lung cancer 8 | 2,890
pediatric high grade glioma 8 | 1,064
subependymal giant cell astrocytoma 8 | 2,287
tuberculosis 8 | 2,010
Astrocytoma, Pilocytic 7 | 3,081
Bipolar Disorder 7 | 666
Hypertensive disease 7 | 292
Insulin Resistance 7 | 72
Stomach Neoplasms 7 | 300
non primary Sjogren syndrome sicca 7 | 891
spina bifida 7 | 1,074
Animal Mammary Neoplasms 6 | 136
Atopic dermatitis 6 | 952
Cognitive delay 6 | 608
Coronary artery disease 6 | 268
Dull intelligence 6 | 645
Epilepsy 6 | 792
Gaucher disease type 1 6 | 180
Global developmental delay 6 | 608
Hypertension 6 | 396
Kidney disease 6 | 430
Low intelligence 6 | 645
Mammary Neoplasms, Animal 6 | 136
Mammary Neoplasms, Experimental 6 | 154
Mental Retardation 6 | 645
Mental and motor retardation 6 | 608
Mental deficiency 6 | 645
Osteoporosis 6 | 363
Polycystic ovary syndrome 6 | 360
Poor school performance 6 | 645
Prostatic Neoplasms 6 | 495
Renal Cell Carcinoma 6 | 214
Vascular disease 6 | 319
juvenile dermatomyositis 6 | 1,187
ulcerative colitis 6 | 1,819
Acquired scoliosis 5 | 281
Curvature of spine 5 | 282
Depressive disorder 5 | 409
Disease Progression 5 | 136
Heart disease 5 | 306
Increased head circumference 5 | 147
Short stature 5 | 531
chronic rhinosinusitis 5 | 512
dermatomyositis 5 | 966

Tissue

Endocrine System 69 | 18,159
Cardiovascular System 68 | 15,192
Digestive Tract 68 | 17,369
Female tissues 68 | 17,400
Liver and Pancreas 68 | 16,750
Skin and soft tissues 68 | 17,230
Blood and immune system 67 | 16,909
Male tissues 67 | 17,142
Respiratory system 67 | 16,393
Urinary Tract 67 | 16,678
Nervous System 66 | 16,725

Target Family

Enzyme 28 | 4,145
Non-IDG 21 | 12,091
Kinase 10 | 634
Transcription Factor 7 | 1,400
Nuclear Receptor 2 | 48
Epigenetic 1 | 242

WikiPathways Pathway

Sterol Regulatory Element-Bind... 69 | 69
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
E3 ubiquitin-protein ligase AMFR AMFR Tbio Enzyme -2.46909 292.8 203
Insulin-induced gene 2 protein INSIG2 Tbio Non-IDG -1.94599 88.7 78
Mediator of RNA polymerase II transcription subunit 15 MED15 Tbio Enzyme -1.60315 40.6 144
Hydroxymethylglutaryl-CoA synthase, cytoplasmic HMGCS1 Tchem Enzyme -1.67608 43.7 137
Glycerol-3-phosphate acyltransferase 1, mitochondrial GPAM Tbio Enzyme -1.93041 83.4 177
Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 Tbio Enzyme -1.48800 26.8 73
ATP-citrate synthase ACLY Tchem Enzyme -2.82704 654.3 332
E3 ubiquitin-protein ligase RNF139 RNF139 Tbio Enzyme -1.17169 16.6 133
Scavenger receptor class B member 1 SCARB1 Tchem Non-IDG -2.93920 915.7 378