Development Level

Tbio 16 | 11,445
Tchem 9 | 1,598
Tclin 4 | 613

IMPC Phenotype

increased circulating choleste... 4 | 66
preweaning lethality, complete... 4 | 979
abnormal embryo size 2 | 220
cardiovascular system phenotyp... 2 | 36
decreased circulating serum al... 2 | 82
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
abnormal lens morphology 1 | 81
abnormal limb bud morphology 1 | 17
abnormal pericardium morpholog... 1 | 26
abnormal sleep behavior 1 | 70
abnormal tooth morphology 1 | 24
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased cardiac muscle contr... 1 | 11
decreased circulating glucose ... 1 | 126
decreased circulating iron lev... 1 | 32
decreased circulating sodium l... 1 | 22
decreased circulating unsatura... 1 | 2
decreased erythrocyte cell num... 1 | 62
decreased exploration in new e... 1 | 11
decreased heart rate 1 | 18
decreased heart rate variabili... 1 | 13
decreased mean corpuscular vol... 1 | 79
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged spleen 1 | 41
increased circulating LDL chol... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating free fat... 1 | 20
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased circulating unsatura... 1 | 1
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
pallor 1 | 34
prolonged PQ interval 1 | 5
prolonged QT interval 1 | 38

Disease

Atherosclerosis 24 | 291
Lipid metabolism disorder 22 | 114
Coronary artery disease 21 | 268
Carcinoma 20 | 11,493
diabetes mellitus 17 | 1,728
Obesity 15 | 678
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
ovarian cancer 14 | 8,520
Cardiovascular system disease 13 | 246
osteosarcoma 13 | 7,950
psoriasis 13 | 6,694
Hypercholesterolemia, Familial 12 | 23
ductal carcinoma in situ 11 | 1,745
glioblastoma 11 | 5,792
invasive ductal carcinoma 11 | 2,951
Hypercholesterolemia 10 | 44
Hyperlipidemia 10 | 43
Hyperlipoproteinemia Type II 10 | 12
malignant mesothelioma 10 | 3,232
Autosomal recessive predisposition 9 | 1,442
oligodendroglioma 9 | 2,850
Serum cholesterol raised 8 | 22
atypical teratoid / rhabdoid tumor 8 | 5,112
ependymoma 8 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
Dyslipidemias 7 | 27
Fatty liver disease 7 | 103
Hypertriglyceridemia 7 | 17
Liver Cirrhosis, Experimental 7 | 769
Vascular disease 7 | 319
adrenocortical carcinoma 7 | 1,428
group 3 medulloblastoma 7 | 4,104
lung cancer 7 | 4,740
pancreatic cancer 7 | 2,398
subependymal giant cell astrocytoma 7 | 2,287
Astrocytoma, Pilocytic 6 | 3,081
Hyperlipidemias 6 | 17
Hypertension 6 | 396
Hypertensive disease 6 | 292
Hypertriglyceridemia result 6 | 37
Kidney cancer 6 | 2,613
Kidney disease 6 | 430
Liver disease 6 | 237
Type 2 diabetes mellitus 6 | 272
Xanthomatosis 6 | 12
adult high grade glioma 6 | 3,801
astrocytic glioma 6 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
lung carcinoma 6 | 2,843
medulloblastoma, large-cell 6 | 6,241
Alzheimer's disease 5 | 658
Arcus Senilis 5 | 11
Breast cancer 5 | 3,578
Cardiovascular Diseases 5 | 59
Cerebrovascular disease 5 | 238
Hypercholesterolemia, Autosomal Dominant, Type B 5 | 5
Hyperlipoproteinemia Type IIa 5 | 11
Low density lipoprotein increased 5 | 8
Metabolic syndrome X 5 | 52
Myocardial Infarction 5 | 151
Schizophrenia 5 | 1,160
Splenomegaly 5 | 190
interstitial cystitis 5 | 2,312
non-small cell lung cancer 5 | 2,890
Age related macular degeneration 4 | 72
Amyloidosis 4 | 67
Angina Pectoris 4 | 32
Cancer 4 | 2,499
Cholestasis 4 | 155
Coronary Disease 4 | 25
Coronary heart disease 4 | 16
Familial hypercholesterolemia - homozygous 4 | 7
Hepatomegaly 4 | 285
High density lipoprotein decreased 4 | 10
Hypoalphalipoproteinemias 4 | 10
Macular degeneration 4 | 65
Pick disease 4 | 1,894
Sitosterolemia 4 | 9
active Crohn's disease 4 | 922
active ulcerative colitis 4 | 764
astrocytoma 4 | 1,146
breast carcinoma 4 | 1,638
lung adenocarcinoma 4 | 2,716
primitive neuroectodermal tumor 4 | 3,035
Anemia 3 | 365
Atopic dermatitis 3 | 952
Carcinoma, Hepatocellular 3 | 228
Down syndrome 3 | 499
Heart disease 3 | 306
Kidney Failure 3 | 111
Liver carcinoma 3 | 240
Lung Neoplasms 3 | 232
acute quadriplegic myopathy 3 | 1,158
colon cancer 3 | 1,478
cystic fibrosis 3 | 1,696
dermatomyositis 3 | 966
juvenile dermatomyositis 3 | 1,187
nasopharyngeal carcinoma 3 | 1,058
primary pancreatic ductal adenocarcinoma 3 | 1,109

Tissue

Digestive Tract 29 | 17,369
Endocrine System 29 | 18,159
Female tissues 29 | 17,400
Liver and Pancreas 29 | 16,750
Skin and soft tissues 28 | 17,230
Male tissues 27 | 17,142
Blood and immune system 26 | 16,909
Urinary Tract 26 | 16,678
Nervous System 24 | 16,725
Respiratory system 23 | 16,393
Cardiovascular System 22 | 15,192

Target Family

Non-IDG 15 | 12,091
Enzyme 11 | 4,145
Transporter 3 | 473

WikiPathways Pathway

Statin Pathway 29 | 29
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Apolipoprotein E APOE Tbio Non-IDG -4.20176 15904.9 976
Apolipoprotein B-100 APOB Tchem Non-IDG -4.00022 10024.1 856
Apolipoprotein A-I APOA1 Tbio Non-IDG -3.62534 3592.8 1151
3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR Tclin Enzyme -3.21450 1428.4 229
Cholesteryl ester transfer protein CETP Tchem Non-IDG -3.20658 1755.9 264
ATP-binding cassette sub-family A member 1 ABCA1 Tclin Transporter -3.15111 1451.8 388
Lipoprotein lipase LPL Tchem Enzyme -3.09646 876.3 338
Low-density lipoprotein receptor LDLR Tchem Non-IDG -3.06808 938.9 585
Scavenger receptor class B member 1 SCARB1 Tchem Non-IDG -2.93920 915.7 378
Apolipoprotein C-III APOC3 Tbio Non-IDG -2.93348 875.2 267