Development Level

Tbio 63 | 11,445
Tchem 38 | 1,598
Tclin 14 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 5 | 979
preweaning lethality, incomple... 5 | 499
decreased erythrocyte cell num... 3 | 62
decreased startle reflex 3 | 75
embryonic lethality prior to t... 3 | 278
increased neutrophil cell numb... 3 | 46
male infertility 3 | 123
short tibia 3 | 97
abnormal embryo size 2 | 220
abnormal retina morphology 2 | 71
abnormal sleep behavior 2 | 70
decreased bone mineral density 2 | 126
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased total body fat amoun... 2 | 207
embryonic lethality prior to o... 2 | 239
female infertility 2 | 60
hyperactivity 2 | 148
hypoactivity 2 | 132
increased circulating alkaline... 2 | 122
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal cecum morphology 1 | 7
abnormal cranium morphology 1 | 36
abnormal digit morphology 1 | 10
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal lung morphology 1 | 26
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal seminal vesicle morph... 1 | 114
absent seminal vesicle 1 | 4
cardiovascular system phenotyp... 1 | 36
convulsive seizures 1 | 13
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating magnesiu... 1 | 13
decreased circulating phosphat... 1 | 27
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased coping response 1 | 8
decreased grip strength 1 | 116
decreased heart rate variabili... 1 | 13
decreased heart weight 1 | 27
decreased lean body mass 1 | 135
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased spleen weight 1 | 10
decreased vertical activity 1 | 208
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged cecum 1 | 5
enlarged heart 1 | 210
enlarged kidney 1 | 14
enlarged uterus 1 | 11
impaired glucose tolerance 1 | 75
increased blood uric acid leve... 1 | 5
increased circulating HDL chol... 1 | 80
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating total pr... 1 | 28
increased eosinophil cell numb... 1 | 11
increased erythrocyte cell num... 1 | 39
increased granulocyte number 1 | 1
increased lean body mass 1 | 172
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased spleen weight 1 | 10
limb grasping 1 | 41
microphthalmia 1 | 26
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
shortened QRS complex duration 1 | 1
small superior vagus ganglion 1 | 74
small uterus 1 | 3
thrombocytopenia 1 | 56
tremors 1 | 39

Disease

Cancer 81 | 2,499
glioblastoma 78 | 5,792
Carcinoma 73 | 11,493
psoriasis 68 | 6,694
ovarian cancer 64 | 8,520
lung cancer 63 | 4,740
medulloblastoma, large-cell 60 | 6,241
ependymoma 56 | 4,679
osteosarcoma 56 | 7,950
atypical teratoid / rhabdoid tumor 55 | 5,112
Astrocytoma, Pilocytic 50 | 3,081
Schizophrenia 50 | 1,160
adult high grade glioma 46 | 3,801
group 3 medulloblastoma 46 | 4,104
malignant mesothelioma 45 | 3,232
Breast cancer 43 | 3,578
lung carcinoma 43 | 2,843
oligodendroglioma 43 | 2,850
pancreatic cancer 41 | 2,398
invasive ductal carcinoma 40 | 2,951
lung adenocarcinoma 40 | 2,716
ulcerative colitis 39 | 1,819
non-small cell lung cancer 38 | 2,890
cystic fibrosis 36 | 1,696
interstitial cystitis 36 | 2,312
diabetes mellitus 33 | 1,728
primitive neuroectodermal tumor 32 | 3,035
Kidney disease 31 | 430
intraductal papillary-mucinous adenoma (IPMA) 31 | 2,955
Multiple Sclerosis 30 | 540
intraductal papillary-mucinous neoplasm (IPMN) 30 | 3,291
pituitary cancer 30 | 1,972
tuberculosis 30 | 2,010
Bipolar Disorder 29 | 666
astrocytic glioma 29 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 29 | 2,989
Cerebrovascular disease 28 | 238
Arthritis 27 | 290
Asthma 27 | 385
Liver Cirrhosis, Experimental 27 | 769
Rheumatoid arthritis 27 | 1,191
subependymal giant cell astrocytoma 26 | 2,287
Atherosclerosis 25 | 291
Depressive disorder 25 | 409
Heart disease 25 | 306
Hypertension 25 | 396
adrenocortical carcinoma 25 | 1,428
astrocytoma 25 | 1,146
Prostatic Neoplasms 24 | 495
breast carcinoma 24 | 1,638
Kidney cancer 22 | 2,613
Lung Neoplasms 22 | 232
colon cancer 22 | 1,478
Endometriosis 21 | 540
Inflammation 21 | 120
Lung disease 21 | 142
cutaneous lupus erythematosus 21 | 1,057
nasopharyngeal carcinoma 21 | 1,058
periodontitis 21 | 293
Alzheimer's disease 20 | 658
Brain Ischemia 20 | 110
Carcinoma, Hepatocellular 20 | 228
Hypersensitivity reaction type II disease 20 | 253
Hypertensive disease 20 | 292
Inflammatory bowel disease 20 | 151
Liver carcinoma 20 | 240
Major Depressive Disorder 20 | 301
Melanoma 20 | 711
Mental Depression 20 | 333
Vascular disease 20 | 319
group 4 medulloblastoma 20 | 1,855
primary pancreatic ductal adenocarcinoma 20 | 1,109
Breast Neoplasms 19 | 445
Mammary Neoplasms 19 | 425
Reperfusion Injury 19 | 86
Toxic encephalopathy 19 | 141
Hyperalgesia 18 | 83
Neoplasm Metastasis 18 | 168
Stomach Neoplasms 18 | 300
ductal carcinoma in situ 18 | 1,745
Coronary artery disease 17 | 268
Obesity 17 | 678
Seizures 17 | 596
Unipolar Depression 17 | 250
acute quadriplegic myopathy 17 | 1,158
dermatomyositis 17 | 966
Alcoholic Intoxication, Chronic 16 | 289
Chemical and Drug Induced Liver Injury 16 | 195
Colonic Neoplasms 16 | 142
Dermatitis 16 | 157
Disease Models, Animal 16 | 155
Myocardial Ischemia 16 | 169
Parkinson's disease 16 | 392
Duchenne muscular dystrophy 15 | 601
Multiple myeloma 15 | 1,332
Pick disease 15 | 1,894
esophageal adenocarcinoma 15 | 737
juvenile dermatomyositis 15 | 1,187
mucosa-associated lymphoid tissue lymphoma 15 | 484
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962

Tissue

Digestive Tract 112 | 17,369
Endocrine System 112 | 18,159
Female tissues 111 | 17,400
Skin and soft tissues 111 | 17,230
Blood and immune system 110 | 16,909
Liver and Pancreas 110 | 16,750
Male tissues 110 | 17,142
Nervous System 109 | 16,725
Respiratory system 108 | 16,393
Urinary Tract 108 | 16,678
Cardiovascular System 97 | 15,192

Target Family

Non-IDG 68 | 12,091
Enzyme 25 | 4,145
Kinase 10 | 634
Transcription Factor 8 | 1,400
GPCR 3 | 408
Ion Channel 1 | 344
Nuclear Receptor 1 | 48

WikiPathways Pathway

Spinal Cord Injury 116 | 116
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Xylosyltransferase 1 XYLT1 Tbio Enzyme -2.10436 129.4 88
Aquaporin-1 AQP1 Tbio Non-IDG -3.08125 1107.4 374
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
Protein BTG2 BTG2 Tbio Non-IDG -2.10376 142.7 209
Collagen alpha-1(IV) chain COL4A1 Tbio Non-IDG -2.28595 186.9 391
Forkhead box protein O3 FOXO3 Tbio Transcription Factor -2.94477 863.9 864
Neuromodulin GAP43 Tbio Non-IDG -2.93905 762.9 597
C-C motif chemokine 2 CCL2 Tchem Non-IDG -3.84820 7088.3 1260
Phospholipase A2, membrane associated PLA2G2A Tchem Enzyme -2.83666 743.3 137
Nitric oxide synthase, inducible NOS2 Tchem Enzyme -3.35134 2277.5 752