Development Level

Tbio 13 | 11,445
Tchem 12 | 1,598

IMPC Phenotype

abnormal bone structure 1 | 187
decreased bone mineral content 1 | 151
decreased circulating creatini... 1 | 39
enlarged heart 1 | 210
increased circulating sodium l... 1 | 71
male infertility 1 | 123
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 19 | 11,493
ovarian cancer 19 | 8,520
osteosarcoma 13 | 7,950
glioblastoma 12 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
medulloblastoma, large-cell 9 | 6,241
psoriasis 9 | 6,694
Astrocytoma, Pilocytic 8 | 3,081
atypical teratoid / rhabdoid tumor 8 | 5,112
ependymoma 8 | 4,679
invasive ductal carcinoma 8 | 2,951
Breast cancer 7 | 3,578
Multiple myeloma 7 | 1,332
adult high grade glioma 7 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
lung adenocarcinoma 7 | 2,716
non-small cell lung cancer 7 | 2,890
cystic fibrosis 6 | 1,696
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
pituitary cancer 6 | 1,972
tuberculosis 6 | 2,010
Cancer 5 | 2,499
lung carcinoma 5 | 2,843
subependymal giant cell astrocytoma 5 | 2,287
Atopic dermatitis 4 | 952
Neurodegenerative disease 4 | 414
Neuronal ceroid lipofuscinosis 9 4 | 5
aldosterone-producing adenoma 4 | 665
astrocytic glioma 4 | 2,597
ductal carcinoma in situ 4 | 1,745
group 3 medulloblastoma 4 | 4,104
lung cancer 4 | 4,740
pancreatic cancer 4 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
primary pancreatic ductal adenocarcinoma 4 | 1,109
Alzheimer's disease 3 | 658
breast carcinoma 3 | 1,638
group 4 medulloblastoma 3 | 1,855
interstitial cystitis 3 | 2,312
malignant mesothelioma 3 | 3,232
Absent reflex 2 | 92
Absent tendon reflex 2 | 92
Autosomal recessive predisposition 2 | 1,442
Cerebellar Ataxia 2 | 304
Congenital Nonbullous Ichthyosiform Erythroderma 2 | 16
Congenital pes cavus 2 | 88
Dementia 2 | 175
Distal limb muscle weakness due to peripheral neuropathy 2 | 62
Distal muscle weakness 2 | 62
Distal sensory impairment 2 | 52
Distal sensory impairment of all modalities 2 | 7
Epilepsies, Myoclonic 2 | 32
Epilepsy 2 | 792
Failure to gain weight 2 | 365
Farber lipogranulomatosis 2 | 9
Gait abnormality 2 | 135
Gaucher's disease 2 | 26
Generalized myoclonic seizures 2 | 30
Hepatomegaly 2 | 285
Hereditary Sensory Autonomic Neuropathy, Type 1 2 | 4
Hydrocephalus 2 | 152
Hyperkyphosis 2 | 111
Ichthyosis 2 | 56
Kidney cancer 2 | 2,613
Kyphosis deformity of spine 2 | 114
Lipid storage disease 2 | 8
Liver Cirrhosis, Experimental 2 | 769
Motor delay 2 | 147
Multiple Sclerosis 2 | 540
Myoclonic Epilepsies, Progressive 2 | 44
Myoclonus 2 | 74
Neuropathy 2 | 261
No development of motor milestones 2 | 147
Pediatric failure to thrive 2 | 365
Pick disease 2 | 1,894
Recurrent respiratory infections 2 | 141
Reflex, Deep Tendon, Absent 2 | 92
Rheumatoid arthritis 2 | 1,191
Short stature 2 | 531
Speech Disorders 2 | 58
Splenomegaly 2 | 190
Waldenstrons macroglobulinemia 2 | 765
active Crohn's disease 2 | 922
active ulcerative colitis 2 | 764
adrenocortical carcinoma 2 | 1,428
astrocytoma 2 | 1,146
cutaneous lupus erythematosus 2 | 1,057
dermatomyositis 2 | 966
diabetes mellitus 2 | 1,728
facioscapulohumeral dystrophy 2 | 288
hepatocellular carcinoma 2 | 547
hereditary spastic paraplegia 2 | 318
nasopharyngeal carcinoma 2 | 1,058
non primary Sjogren syndrome sicca 2 | 891
oligodendroglioma 2 | 2,850
posterior fossa group A ependymoma 2 | 468
primitive neuroectodermal tumor 2 | 3,035
spina bifida 2 | 1,074
tuberculosis and treatment for 6 months 2 | 409
urothelial carcinoma 2 | 318

Tissue

Blood and immune system 25 | 16,909
Cardiovascular System 25 | 15,192
Digestive Tract 25 | 17,369
Endocrine System 25 | 18,159
Female tissues 25 | 17,400
Liver and Pancreas 25 | 16,750
Male tissues 25 | 17,142
Nervous System 25 | 16,725
Respiratory system 25 | 16,393
Skin and soft tissues 25 | 17,230
Urinary Tract 25 | 16,678

Target Family

Enzyme 16 | 4,145
Transcription Factor 5 | 1,400
Kinase 3 | 634
Non-IDG 1 | 12,091

WikiPathways Pathway

Sphingolipid Metabolism 25 | 25
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Non-lysosomal glucosylceramidase GBA2 Tchem Enzyme -1.62330 43.1 59
Sphingosine-1-phosphate phosphatase 2 SGPP2 Tbio Enzyme -0.72925 6.15 77
Ceramide synthase 6 CERS6 Tbio Transcription Factor -1.48442 32.4 167
3-ketodihydrosphingosine reductase KDSR Tbio Enzyme -1.21646 15.3 101
Ceramide synthase 3 CERS3 Tbio Transcription Factor -1.06194 11.5 105
Phosphatidylcholine:ceramide cholinephosphotransferase 2 SGMS2 Tchem Enzyme -1.45924 31.1 204
Serine palmitoyltransferase 1 SPTLC1 Tchem Enzyme -2.16711 143.2 285
Neutral ceramidase ASAH2 Tbio Enzyme -1.83454 47.6 144
Ceramide synthase 4 CERS4 Tbio Transcription Factor -1.57021 34.5 228
Ceramide kinase CERK Tchem Kinase -1.84215 79.4 229