Development Level

Tbio 11 | 11,445
Tchem 7 | 1,598

IMPC Phenotype

preweaning lethality, incomple... 3 | 499
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal eye anterior chamber ... 1 | 9
abnormal heart left ventricle ... 1 | 16
abnormal skin appearance 1 | 3
absent startle reflex 1 | 24
decreased caudal vertebrae num... 1 | 53
decreased circulating alkaline... 1 | 46
decreased circulating total pr... 1 | 49
impaired pupillary reflex 1 | 26
impaired righting response 1 | 26
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
pallor 1 | 34
preweaning lethality, complete... 1 | 979

Disease

Carcinoma 13 | 11,493
Cancer 11 | 2,499
glioblastoma 10 | 5,792
ependymoma 9 | 4,679
osteosarcoma 9 | 7,950
ovarian cancer 9 | 8,520
astrocytic glioma 8 | 2,597
lung cancer 8 | 4,740
Astrocytoma, Pilocytic 7 | 3,081
Kidney disease 7 | 430
adult high grade glioma 7 | 3,801
malignant mesothelioma 7 | 3,232
psoriasis 7 | 6,694
Prostatic Neoplasms 6 | 495
atypical teratoid / rhabdoid tumor 6 | 5,112
diabetes mellitus 6 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
Breast Neoplasms 5 | 445
Breast cancer 5 | 3,578
Liver Cirrhosis, Experimental 5 | 769
Mammary Neoplasms 5 | 425
Schizophrenia 5 | 1,160
gastric carcinoma 5 | 807
invasive ductal carcinoma 5 | 2,951
lung carcinoma 5 | 2,843
medulloblastoma, large-cell 5 | 6,241
oligodendroglioma 5 | 2,850
pancreatic cancer 5 | 2,398
Acute kidney injury 4 | 70
Arthritis 4 | 290
Chronic obstructive pulmonary disease 4 | 184
Cleft Palate 4 | 271
Down syndrome 4 | 499
Hyperglycemia 4 | 137
Kidney cancer 4 | 2,613
Pulmonary Fibrosis 4 | 106
Toxic encephalopathy 4 | 141
Vascular disease 4 | 319
cystic fibrosis 4 | 1,696
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
non-small cell lung cancer 4 | 2,890
subependymal giant cell astrocytoma 4 | 2,287
Abortion, Spontaneous 3 | 109
Carcinoma, Squamous Cell 3 | 110
Cholestasis 3 | 155
Diabetes Mellitus, Experimental 3 | 108
Diabetic Nephropathies 3 | 37
Diabetic Nephropathy 3 | 34
Duchenne muscular dystrophy 3 | 601
Heart disease 3 | 306
Hyperplasia 3 | 27
Kidney Diseases 3 | 114
Liver Cirrhosis 3 | 181
Mood Disorders 3 | 184
Non-alcoholic Fatty Liver Disease 3 | 42
Obesity 3 | 678
Parkinson's disease 3 | 392
Spontaneous abortion 3 | 113
Squamous cell carcinoma 3 | 129
Stomach Neoplasms 3 | 300
active Crohn's disease 3 | 922
acute quadriplegic myopathy 3 | 1,158
breast carcinoma 3 | 1,638
colon cancer 3 | 1,478
dermatomyositis 3 | 966
ductal carcinoma in situ 3 | 1,745
interstitial cystitis 3 | 2,312
juvenile dermatomyositis 3 | 1,187
lung adenocarcinoma 3 | 2,716
nasopharyngeal carcinoma 3 | 1,058
primary pancreatic ductal adenocarcinoma 3 | 1,109
primitive neuroectodermal tumor 3 | 3,035
ulcerative colitis 3 | 1,819
Adenocarcinoma of lung 2 | 142
Alcoholic Intoxication, Chronic 2 | 289
Bladder Neoplasm 2 | 112
Carcinoma, Hepatocellular 2 | 228
Exophthalmos 2 | 112
Focal glomerulosclerosis 2 | 37
Glomerulosclerosis, Focal Segmental 2 | 28
Kidney Failure 2 | 111
Liver carcinoma 2 | 240
Lung Neoplasms 2 | 232
Microstomia 2 | 78
Myopia 2 | 176
Neoplasm Invasiveness 2 | 161
Neurodegenerative disease 2 | 414
Neurogenic Muscular Atrophy 2 | 139
Neurogenic muscle atrophy, especially in the lower limbs 2 | 139
Prominent eyes 2 | 96
Prominent globes 2 | 96
Proteinuria 2 | 144
Protruding eyes 2 | 96
Renal Insufficiency 2 | 90
Renal failure in adulthood 2 | 76
Skeletal muscle atrophy 2 | 139
Urinary Bladder Neoplasms 2 | 114
medulloblastoma 2 | 720
muscle degeneration 2 | 139

Tissue

Digestive Tract 18 | 17,369
Endocrine System 18 | 18,159
Female tissues 18 | 17,400
Liver and Pancreas 18 | 16,750
Male tissues 18 | 17,142
Nervous System 18 | 16,725
Skin and soft tissues 18 | 17,230
Urinary Tract 18 | 16,678
Blood and immune system 17 | 16,909
Cardiovascular System 17 | 15,192
Respiratory system 17 | 16,393

Target Family

Non-IDG 11 | 12,091
Enzyme 2 | 4,145
Epigenetic 2 | 242
Transcription Factor 2 | 1,400
Kinase 1 | 634

WikiPathways Pathway

Simplified Interaction Map Bet... 18 | 18
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Fibronectin FN1 Tchem Non-IDG -3.09873 1208.8 1583
Epithelial discoidin domain-containing receptor 1 DDR1 Tchem Kinase -2.26801 0.00000 534
NAD(P)H dehydrogenase [quinone] 1 NQO1 Tchem Enzyme -3.12097 1326.4 550
Bone morphogenetic protein 2 BMP2 Tbio Non-IDG -3.65728 4647.9 684
Polycystin-1 PKD1 Tbio Non-IDG -2.60276 379.9 123
Nuclear factor erythroid 2-related factor 2 NFE2L2 Tchem Transcription Factor -3.14284 1506.7 552
Insulin-like growth factor-binding protein 7 IGFBP7 Tbio Non-IDG -2.54840 380.0 373
Hsp90 co-chaperone Cdc37 CDC37 Tbio Non-IDG -0.96438 12.8 409
Histone-lysine N-methyltransferase SUV39H1 SUV39H1 Tchem Epigenetic -2.27556 174.3 306
Transforming growth factor beta-1 TGFB1 Tchem Non-IDG -3.84680 5672.0 1222