Development Level

Tchem 43 | 1,598
Tbio 22 | 11,445
Tclin 18 | 613

Collection

Kinase: IDG Consortium (Target... 3 | 125

IMPC Phenotype

preweaning lethality, complete... 9 | 979
decreased body weight 4 | 161
preweaning lethality, incomple... 4 | 499
abnormal embryo size 3 | 220
abnormal lens morphology 3 | 81
cataract 3 | 92
decreased circulating creatini... 3 | 39
male infertility 3 | 123
abnormal bone mineralization 2 | 38
abnormal seminal vesicle morph... 2 | 114
abnormal testis morphology 2 | 43
decreased bone mineral density 2 | 126
decreased circulating alanine ... 2 | 47
decreased circulating choleste... 2 | 93
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased total body fat amoun... 2 | 207
embryonic growth retardation 2 | 106
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
increased circulating alkaline... 2 | 122
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
increased total body fat amoun... 2 | 134
small testis 2 | 58
abnormal behavior 1 | 298
abnormal digit morphology 1 | 10
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal glucose homeostasis 1 | 4
abnormal heart morphology 1 | 162
abnormal lung morphology 1 | 26
abnormal retina morphology 1 | 71
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
decreased IgG3 level 1 | 1
decreased circulating LDL chol... 1 | 38
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating free fat... 1 | 31
decreased circulating insulin ... 1 | 76
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lactate dehydrogenas... 1 | 16
decreased leukocyte cell numbe... 1 | 73
decreased mature B cell number 1 | 7
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
edema 1 | 59
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
female infertility 1 | 60
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased circulating LDL chol... 1 | 13
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased heart left ventricle... 1 | 4
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
microphthalmia 1 | 26
prenatal lethality 1 | 28
short tibia 1 | 97
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74
thrombocytopenia 1 | 56
thrombocytosis 1 | 27

Disease

Carcinoma 73 | 11,493
Cancer 70 | 2,499
ovarian cancer 66 | 8,520
osteosarcoma 55 | 7,950
glioblastoma 53 | 5,792
lung cancer 51 | 4,740
medulloblastoma, large-cell 49 | 6,241
psoriasis 47 | 6,694
Breast cancer 44 | 3,578
atypical teratoid / rhabdoid tumor 42 | 5,112
Kidney cancer 41 | 2,613
ependymoma 34 | 4,679
Breast Neoplasms 30 | 445
Mammary Neoplasms 30 | 425
group 3 medulloblastoma 30 | 4,104
adult high grade glioma 29 | 3,801
malignant mesothelioma 29 | 3,232
oligodendroglioma 29 | 2,850
subependymal giant cell astrocytoma 28 | 2,287
primitive neuroectodermal tumor 27 | 3,035
Lung Neoplasms 25 | 232
invasive ductal carcinoma 25 | 2,951
Schizophrenia 24 | 1,160
astrocytic glioma 24 | 2,597
lung adenocarcinoma 24 | 2,716
Astrocytoma, Pilocytic 23 | 3,081
Stomach Neoplasms 23 | 300
Intellectual disability 22 | 1,016
Seizures 22 | 596
pancreatic cancer 22 | 2,398
Cognitive delay 21 | 608
Dull intelligence 21 | 645
Epilepsy 21 | 792
Global developmental delay 21 | 608
Low intelligence 21 | 645
Mental Retardation 21 | 645
Mental and motor retardation 21 | 608
Mental deficiency 21 | 645
Poor school performance 21 | 645
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,291
non-small cell lung cancer 21 | 2,890
Melanoma 20 | 711
Prostatic Neoplasms 20 | 495
breast carcinoma 20 | 1,638
Carcinoma, Hepatocellular 19 | 228
Liver carcinoma 19 | 240
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,955
Autosomal recessive predisposition 18 | 1,442
Orbital separation excessive 18 | 244
Short stature 18 | 531
ductal carcinoma in situ 18 | 1,745
lung carcinoma 18 | 2,843
pituitary cancer 18 | 1,972
ulcerative colitis 18 | 1,819
Liver cancer 17 | 604
Renal Cell Carcinoma 17 | 214
Squamous cell carcinoma 17 | 129
diabetes mellitus 17 | 1,728
juvenile dermatomyositis 17 | 1,187
nasopharyngeal carcinoma 17 | 1,058
Adenoma 16 | 167
Blepharoptosis 16 | 231
Carcinoma, Squamous Cell 16 | 110
Concave bridge of nose 16 | 195
DOID:2627 16 | 94
Depressed nasal bridge 16 | 195
Depressed nasal root/bridge 16 | 195
Downward slant of palpebral fissure 16 | 158
Hypoplastic mandible condyle 16 | 275
Mandibular hypoplasia 16 | 275
Micrognathism 16 | 275
adrenocortical carcinoma 16 | 1,428
astrocytoma 16 | 1,146
interstitial cystitis 16 | 2,312
Endometrial cancer 15 | 311
Pick disease 15 | 1,894
colon cancer 15 | 1,478
tuberculosis 15 | 2,010
Frontal bossing 14 | 157
Ovarian Neoplasms 14 | 102
Rheumatoid arthritis 14 | 1,191
Vascular disease 14 | 319
acute quadriplegic myopathy 14 | 1,158
spina bifida 14 | 1,074
Big calvaria 13 | 147
Byzanthine arch palate 13 | 194
Depressive disorder 13 | 409
Immune system cancer 13 | 140
Increased head circumference 13 | 147
Increased size of cranium 13 | 147
Increased size of skull 13 | 147
Melanocytic nevus 13 | 43
Muscle hypotonia 13 | 571
ovarian neoplasm 13 | 99
Acquired scoliosis 12 | 281
Bipolar Disorder 12 | 666
Curvature of spine 12 | 282
Pectus excavatum 12 | 100
Strabismus 12 | 270

Tissue

Blood and immune system 82 | 16,909
Digestive Tract 82 | 17,369
Endocrine System 82 | 18,159
Female tissues 82 | 17,400
Liver and Pancreas 82 | 16,750
Male tissues 82 | 17,142
Nervous System 82 | 16,725
Skin and soft tissues 82 | 17,230
Respiratory system 81 | 16,393
Urinary Tract 81 | 16,678
Cardiovascular System 79 | 15,192

Target Family

Kinase 46 | 634
Non-IDG 16 | 12,091
Enzyme 14 | 4,145
Transcription Factor 5 | 1,400
Epigenetic 2 | 242

WikiPathways Pathway

Signaling Pathways in Glioblas... 83 | 83
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -3.05358 1143.3 1478
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Forkhead box protein O3 FOXO3 Tbio Transcription Factor -2.94477 863.9 864
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.41628 245.1 733
ERBB receptor feedback inhibitor 1 ERRFI1 Tbio Non-IDG -1.86682 77.3 148