Development Level

Tchem 12 | 1,388
Tbio 10 | 11,651
Tclin 3 | 612

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

male infertility 2 | 123
abnormal bone mineralization 1 | 38
abnormal glucose homeostasis 1 | 4
abnormal retinal blood vessel ... 1 | 26
abnormal skin coloration 1 | 25
abnormal spleen morphology 1 | 55
abnormal vocalization 1 | 21
decreased body weight 1 | 161
decreased circulating LDL chol... 1 | 38
decreased circulating choleste... 1 | 93
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
female infertility 1 | 60
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased lean body mass 1 | 172
increased total body fat amoun... 1 | 134
preweaning lethality, complete... 1 | 979
thrombocytosis 1 | 27

Disease

Carcinoma 19 | 11,493
glioblastoma 12 | 5,792
ovarian cancer 11 | 8,520
Cancer 10 | 2,499
ependymoma 10 | 4,679
osteosarcoma 10 | 7,950
group 3 medulloblastoma 9 | 4,104
lung cancer 9 | 4,740
psoriasis 9 | 6,694
Breast cancer 8 | 3,578
medulloblastoma, large-cell 8 | 6,241
atypical teratoid / rhabdoid tumor 7 | 5,112
primitive neuroectodermal tumor 7 | 3,035
Schizophrenia 6 | 1,160
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
ulcerative colitis 6 | 1,819
Astrocytoma, Pilocytic 5 | 3,081
Bipolar Disorder 5 | 666
Epilepsy 5 | 792
Multiple Sclerosis 5 | 540
Vascular disease 5 | 319
astrocytoma 5 | 1,146
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
invasive ductal carcinoma 5 | 2,951
malignant mesothelioma 5 | 3,232
subependymal giant cell astrocytoma 5 | 2,287
tuberculosis 5 | 2,010
Arthritis 4 | 290
Autosomal recessive predisposition 4 | 1,442
Dull intelligence 4 | 645
Intellectual disability 4 | 1,016
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Obesity 4 | 678
Pick disease 4 | 1,894
Poor school performance 4 | 645
adult high grade glioma 4 | 3,801
breast carcinoma 4 | 1,638
colon cancer 4 | 1,478
diabetes mellitus 4 | 1,728
interstitial cystitis 4 | 2,312
non-small cell lung cancer 4 | 2,890
pediatric high grade glioma 4 | 1,064
pituitary cancer 4 | 1,972
Big calvaria 3 | 147
Breast Neoplasms 3 | 445
Carcinoma, Squamous Cell 3 | 110
Cardiomyopathies 3 | 110
Disease Models, Animal 3 | 155
Hyperalgesia 3 | 83
Increased head circumference 3 | 147
Increased size of cranium 3 | 147
Increased size of skull 3 | 147
Kidney cancer 3 | 2,613
Liver Cirrhosis, Experimental 3 | 769
Lung Neoplasms 3 | 232
Lymphopenia 3 | 67
Mammary Neoplasms 3 | 425
Mental Depression 3 | 333
Neoplasm Invasiveness 3 | 161
Neoplasm Metastasis 3 | 168
Osteoporosis 3 | 363
Ovarian Neoplasms 3 | 102
Relapsing remitting multiple sclerosis 3 | 14
Seizures 3 | 596
Squamous cell carcinoma 3 | 129
Stomach Neoplasms 3 | 300
Substance Withdrawal Syndrome 3 | 55
cystic fibrosis 3 | 1,696
ductal carcinoma in situ 3 | 1,745
juvenile dermatomyositis 3 | 1,187
lung adenocarcinoma 3 | 2,716
lung carcinoma 3 | 2,843
nasopharyngeal carcinoma 3 | 1,058
oligodendroglioma 3 | 2,850
ovarian neoplasm 3 | 99
pancreatic cancer 3 | 2,398
primary Sjogren syndrome 3 | 735
Acquired scoliosis 2 | 281
Alzheimer's disease 2 | 658
Atopic dermatitis 2 | 952
Brain Ischemia 2 | 110
Cocaine-Related Disorders 2 | 92
Concave bridge of nose 2 | 195
Curvature of spine 2 | 282
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Depressive disorder 2 | 409
Heart disease 2 | 306
Hepatomegaly 2 | 285
Hyperplasia 2 | 27
Kidney disease 2 | 430
Lung disease 2 | 142
Parkinson's disease 2 | 392
Polycystic ovary syndrome 2 | 360
Waldenstrons macroglobulinemia 2 | 765
adrenocortical carcinoma 2 | 1,428
fibroadenoma 2 | 559

Tissue

Blood and immune system 25 | 16,909
Cardiovascular System 25 | 15,192
Digestive Tract 25 | 17,369
Endocrine System 25 | 18,159
Female tissues 25 | 17,400
Liver and Pancreas 25 | 16,750
Male tissues 25 | 17,142
Nervous System 25 | 16,725
Respiratory system 25 | 16,393
Skin and soft tissues 25 | 17,230
Urinary Tract 25 | 16,678

Target Family

Kinase 12 | 634
Enzyme 6 | 4,145
GPCR 4 | 408
Non-IDG 3 | 12,091

WikiPathways Pathway

Signal Transduction of S1P Rec... 25 | 25
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 PLCB1 Tbio Enzyme -2.50444 332.8 190
Mitogen-activated protein kinase 7 MAPK7 Tbio Kinase -2.48754 340.0 422
Sphingosine kinase 2 SPHK2 Tchem Kinase -2.21878 154.9 314
Acid ceramidase ASAH1 Tchem Enzyme -2.94716 848.0 203
Guanine nucleotide-binding protein G(i) subunit alpha-1 GNAI1 Tbio Non-IDG -0.63224 3.23 220
Mitogen-activated protein kinase 12 MAPK12 Tchem Kinase -1.95173 88.4 378
Guanine nucleotide-binding protein G(i) subunit alpha-2 GNAI2 Tbio Non-IDG -1.25466 17.2 212
Sphingosine kinase 1 SPHK1 Tchem Kinase -2.72994 583.6 518
Mitogen-activated protein kinase 3 MAPK3 Tchem Kinase -3.66226 3484.0 1440
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.18822 1239.4 1248