Development Level

Tbio 9 | 11,445
Tchem 7 | 1,598
Tclin 6 | 613

IMPC Phenotype

abnormal bone structure 6 | 187
increased heart weight 5 | 62
increased startle reflex 4 | 112
decreased body weight 2 | 161
decreased total body fat amoun... 2 | 207
abnormal bone mineralization 1 | 38
abnormal clavicle morphology 1 | 6
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal hindbrain development 1 | 16
abnormal joint morphology 1 | 23
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal optic disc morphology 1 | 10
absent seminal vesicle 1 | 4
corneal opacity 1 | 32
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating glycerol... 1 | 16
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased mature B cell number 1 | 7
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
female infertility 1 | 60
impaired pupillary reflex 1 | 26
increased B cell number 1 | 9
increased T cell number 1 | 6
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating chloride... 1 | 41
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating sodium l... 1 | 71
increased lactate dehydrogenas... 1 | 3
male infertility 1 | 123
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
small uterus 1 | 3

Disease

Carcinoma 18 | 11,493
ovarian cancer 16 | 8,520
Cancer 14 | 2,499
osteosarcoma 13 | 7,950
glioblastoma 11 | 5,792
medulloblastoma, large-cell 11 | 6,241
psoriasis 11 | 6,694
lung cancer 10 | 4,740
Obesity 9 | 678
Schizophrenia 9 | 1,160
atypical teratoid / rhabdoid tumor 9 | 5,112
Breast cancer 8 | 3,578
Alzheimer's disease 7 | 658
Depressive disorder 7 | 409
Kidney cancer 7 | 2,613
Substance Withdrawal Syndrome 7 | 55
ependymoma 7 | 4,679
pancreatic cancer 7 | 2,398
Bipolar Disorder 6 | 666
Brachydactyly 6 | 156
Cocaine-Related Disorders 6 | 92
Cushing's syndrome 6 | 48
Kidney disease 6 | 430
Multiple myeloma 6 | 1,332
Short stature 6 | 531
diabetes mellitus 6 | 1,728
group 3 medulloblastoma 6 | 4,104
pituitary cancer 6 | 1,972
primitive neuroectodermal tumor 6 | 3,035
ulcerative colitis 6 | 1,819
Acromegaly 5 | 51
Adenoma 5 | 167
Biliary tract cancer 5 | 19
Dull intelligence 5 | 645
Epilepsy 5 | 792
Intellectual disability 5 | 1,016
Liver cancer 5 | 604
Low intelligence 5 | 645
Major Depressive Disorder 5 | 301
Melanoma 5 | 711
Mental Depression 5 | 333
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Mood Disorders 5 | 184
Parkinson's disease 5 | 392
Pick disease 5 | 1,894
Pituitary adenoma 5 | 38
Plummer's disease 5 | 11
Polycystic ovary syndrome 5 | 360
Poor school performance 5 | 645
Small intestine cancer 5 | 12
Stomach cancer 5 | 30
Thyroid cancer 5 | 36
Vascular disease 5 | 319
invasive ductal carcinoma 5 | 2,951
oligodendroglioma 5 | 2,850
Acquired scoliosis 4 | 281
Adrenal gland cancer 4 | 12
Amnestic disorder 4 | 35
Blepharoptosis 4 | 231
Bone cancer 4 | 16
Brain Ischemia 4 | 110
Byzanthine arch palate 4 | 194
Cafe au lait spots, multiple 4 | 17
Carney complex 4 | 25
Cervix carcinoma 4 | 10
Coarse facial features 4 | 108
Concave bridge of nose 4 | 195
Curvature of spine 4 | 282
Depressed nasal bridge 4 | 195
Depressed nasal root/bridge 4 | 195
Failure to gain weight 4 | 365
Fibrous dysplasia 4 | 15
Generalized hyperpigmentation 4 | 22
Heart disease 4 | 306
Hyperphosphatemia 4 | 32
Hyperthyroidism 4 | 53
Hypoparathyroidism 4 | 41
Hypothyroidism 4 | 122
Large auricle 4 | 87
Large dysplastic ears 4 | 87
Large pinnae 4 | 87
Large prominent ears 4 | 87
Large protruding ears 4 | 87
Large, floppy ears 4 | 87
Lung Neoplasms 4 | 232
Macrotia 4 | 87
McCune Albright syndrome 4 | 19
Pediatric failure to thrive 4 | 365
Premature Birth 4 | 77
Premature birth of newborn 4 | 67
Primary pigmented nodular adrenocortical disease 4 | 13
Prostatic Neoplasms 4 | 495
Pseudohypoparathyroidism 4 | 18
Strabismus 4 | 270
Thickened facial skin with coarse facial features 4 | 108
adult high grade glioma 4 | 3,801
juvenile dermatomyositis 4 | 1,187
subependymal giant cell astrocytoma 4 | 2,287
substance-related disorder 4 | 162

Tissue

Digestive Tract 19 | 17,369
Endocrine System 19 | 18,159
Nervous System 19 | 16,725
Blood and immune system 18 | 16,909
Cardiovascular System 18 | 15,192
Female tissues 18 | 17,400
Liver and Pancreas 18 | 16,750
Respiratory system 18 | 16,393
Skin and soft tissues 18 | 17,230
Male tissues 17 | 17,142
Urinary Tract 17 | 16,678

Target Family

Kinase 7 | 634
Transcription Factor 6 | 1,400
Non-IDG 4 | 12,091
GPCR 3 | 408
Enzyme 1 | 4,145
Nuclear Receptor 1 | 48

WikiPathways Pathway

Serotonin Receptor 4/6/7 and N... 22 | 22
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
5-hydroxytryptamine receptor 4 HTR4 Tclin GPCR -2.87235 796.4 248
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
5-hydroxytryptamine receptor 6 HTR6 Tchem GPCR -2.31880 213.2 64
ETS domain-containing protein Elk-4 ELK4 Tbio Transcription Factor -1.07328 11.4 100
Protein ALEX GNAS Tbio Non-IDG -2.63356 1389.7 509
ETS domain-containing protein Elk-1 ELK1 Tbio Transcription Factor -0.51976 3.02 941
Serum response factor SRF Tbio Transcription Factor -2.94583 721.8 474
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas GNAS Tbio Non-IDG -2.63356 1389.7 509
5-hydroxytryptamine receptor 7 HTR7 Tclin GPCR -4.15964 13643.7 259
Cyclic AMP-dependent transcription factor ATF-1 ATF1 Tchem Transcription Factor -1.74625 53.7 445