Development Level

Tchem 8 | 1,598
Tbio 6 | 11,445
Tclin 6 | 613

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal bone structure 2 | 187
decreased body weight 2 | 161
decreased circulating choleste... 2 | 93
decreased lean body mass 2 | 135
increased circulating glucose ... 2 | 24
short tibia 2 | 97
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal clavicle morphology 1 | 6
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal gait 1 | 69
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal optic disc morphology 1 | 10
cataract 1 | 92
corneal opacity 1 | 32
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating chloride... 1 | 30
decreased circulating fructosa... 1 | 30
decreased circulating glycerol... 1 | 16
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased mature B cell number 1 | 7
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
increased B cell number 1 | 9
increased T cell number 1 | 6
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating iron lev... 1 | 30
increased heart weight 1 | 62
increased lactate dehydrogenas... 1 | 3
increased total body fat amoun... 1 | 134
prenatal lethality 1 | 28
preweaning lethality, incomple... 1 | 499
small epididymis 1 | 3

Disease

Carcinoma 18 | 11,493
ovarian cancer 14 | 8,520
glioblastoma 12 | 5,792
medulloblastoma, large-cell 11 | 6,241
osteosarcoma 11 | 7,950
psoriasis 11 | 6,694
Cancer 10 | 2,499
atypical teratoid / rhabdoid tumor 10 | 5,112
ependymoma 10 | 4,679
lung cancer 9 | 4,740
Cognitive delay 8 | 608
Dull intelligence 8 | 645
Global developmental delay 8 | 608
Intellectual disability 8 | 1,016
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental and motor retardation 8 | 608
Mental deficiency 8 | 645
Poor school performance 8 | 645
Short stature 8 | 531
astrocytic glioma 8 | 2,597
malignant mesothelioma 8 | 3,232
oligodendroglioma 8 | 2,850
primitive neuroectodermal tumor 8 | 3,035
Byzanthine arch palate 7 | 194
Cryptorchidism 7 | 296
Kidney cancer 7 | 2,613
Muscle hypotonia 7 | 571
Pick disease 7 | 1,894
Strabismus 7 | 270
group 3 medulloblastoma 7 | 4,104
Biparietal narrowing 6 | 28
Bipolar Disorder 6 | 666
Blepharoptosis 6 | 231
Breast cancer 6 | 3,578
Congenital Epicanthus 6 | 177
Decreased width of the skull 6 | 28
Downward slant of palpebral fissure 6 | 158
Epilepsy 6 | 792
High forehead 6 | 102
Hypoplastic mandible condyle 6 | 275
Mandibular hypoplasia 6 | 275
Melanoma 6 | 711
Micrognathism 6 | 275
Neck webbing 6 | 35
Noonan syndrome 6 | 34
Orbital separation excessive 6 | 244
Schizophrenia 6 | 1,160
Seizures 6 | 596
Short neck 6 | 140
Tall forehead 6 | 102
adult high grade glioma 6 | 3,801
juvenile dermatomyositis 6 | 1,187
ulcerative colitis 6 | 1,819
Abnormality of vision 5 | 40
Acquired scoliosis 5 | 281
Astrocytoma, Pilocytic 5 | 3,081
Atrial Septal Defects 5 | 85
Attention deficit hyperactivity disorder 5 | 278
Big calvaria 5 | 147
Cardiomyopathy 5 | 116
Chubby cheeks 5 | 50
Concave bridge of nose 5 | 195
Curly hair (finding) 5 | 14
Curvature of spine 5 | 282
Depressed nasal bridge 5 | 195
Depressed nasal root/bridge 5 | 195
Electroencephalogram abnormal 5 | 101
Feeding difficulties in infancy 5 | 175
Frontal bossing 5 | 157
Full cheeks 5 | 50
Heart disease 5 | 306
Hemangioma, Cavernous 5 | 20
Hyperplasia of cheeks 5 | 50
Hypertrophy of cheeks 5 | 50
Ichthyoses 5 | 41
Increased head circumference 5 | 147
Increased size of cranium 5 | 147
Increased size of skull 5 | 147
Low posterior hairline 5 | 52
Low set ears 5 | 181
Low-set, posteriorly rotated ears 5 | 110
Lung Neoplasms 5 | 232
Pectus excavatum 5 | 100
Premature Birth 5 | 77
Premature birth of newborn 5 | 67
Puffy cheeks 5 | 50
Pulmonary Stenosis 5 | 45
Short nose 5 | 132
Small nose 5 | 132
Stomach Neoplasms 5 | 300
Thickened helices 5 | 15
Anteverted nostril 4 | 191
Delayed bone age 4 | 136
Depressive disorder 4 | 409
Failure to thrive in infancy 4 | 32
Long philtrum 4 | 137
Major Depressive Disorder 4 | 301
Vascular disease 4 | 319
Ventricular Septal Defects 4 | 119

Tissue

Female tissues 20 | 17,400
Male tissues 20 | 17,142
Blood and immune system 19 | 16,909
Cardiovascular System 19 | 15,192
Digestive Tract 19 | 17,369
Endocrine System 19 | 18,159
Liver and Pancreas 19 | 16,750
Nervous System 19 | 16,725
Respiratory system 19 | 16,393
Skin and soft tissues 18 | 17,230
Urinary Tract 18 | 16,678

Target Family

Kinase 6 | 634
Transcription Factor 4 | 1,400
Enzyme 3 | 4,145
GPCR 3 | 408
Non-IDG 3 | 12,091
Ion Channel 1 | 344

WikiPathways Pathway

Serotonin Receptor 2 and ELK-S... 20 | 20
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Guanine nucleotide-binding protein G(q) subunit alpha GNAQ Tbio Non-IDG -2.73429 514.5 206
ETS domain-containing protein Elk-4 ELK4 Tbio Transcription Factor -1.07328 11.4 100
5-hydroxytryptamine receptor 2B HTR2B Tclin GPCR -2.66641 486.3 265
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
Serum response factor SRF Tbio Transcription Factor -2.94583 721.8 474
ETS domain-containing protein Elk-1 ELK1 Tbio Transcription Factor -0.51976 3.02 941
RAS guanyl-releasing protein 1 RASGRP1 Tchem Non-IDG -1.99263 105.6 99