Development Level

Tbio 68 | 11,445
Tchem 25 | 1,598
Tclin 13 | 613

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 9 | 979
enlarged heart 5 | 210
preweaning lethality, incomple... 5 | 499
abnormal behavior 4 | 298
abnormal heart morphology 4 | 162
abnormal lens morphology 4 | 81
abnormal lung morphology 4 | 26
cataract 4 | 92
abnormal seminal vesicle morph... 3 | 114
decreased vertical activity 3 | 208
abnormal coat-hair pigmentatio... 2 | 64
abnormal embryo size 2 | 220
abnormal eye morphology 2 | 68
abnormal testis morphology 2 | 43
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased circulating bilirubi... 2 | 19
decreased circulating glucose ... 2 | 126
decreased circulating insulin ... 2 | 76
decreased total body fat amoun... 2 | 207
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
increased bone mineral content 2 | 108
increased mean corpuscular hem... 2 | 96
small testis 2 | 58
abnormal craniofacial morpholo... 1 | 33
abnormal epididymis morphology 1 | 42
abnormal femur morphology 1 | 14
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal hindbrain morphology 1 | 10
abnormal humerus morphology 1 | 11
abnormal incisor color 1 | 3
abnormal liver morphology 1 | 17
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal spleen morphology 1 | 55
abnormal tibia morphology 1 | 14
abnormal tooth morphology 1 | 24
abnormal urinary bladder morph... 1 | 11
anophthalmia 1 | 33
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating serum al... 1 | 82
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased red blood cell distr... 1 | 41
edema 1 | 59
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
female infertility 1 | 60
hemorrhage 1 | 23
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
increased body length 1 | 32
increased bone mineral density 1 | 72
increased circulating LDL chol... 1 | 13
increased circulating serum al... 1 | 22
increased erythrocyte cell num... 1 | 39
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased lean body mass 1 | 172
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
male infertility 1 | 123
microphthalmia 1 | 26
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
small seminal vesicle 1 | 10

Disease

Cancer 77 | 2,499
ovarian cancer 74 | 8,520
Carcinoma 68 | 11,493
osteosarcoma 62 | 7,950
psoriasis 58 | 6,694
glioblastoma 57 | 5,792
lung cancer 52 | 4,740
medulloblastoma, large-cell 45 | 6,241
malignant mesothelioma 43 | 3,232
Breast cancer 42 | 3,578
atypical teratoid / rhabdoid tumor 39 | 5,112
ependymoma 37 | 4,679
pancreatic cancer 37 | 2,398
Astrocytoma, Pilocytic 33 | 3,081
tuberculosis 32 | 2,010
invasive ductal carcinoma 31 | 2,951
adult high grade glioma 29 | 3,801
Breast Neoplasms 28 | 445
Mammary Neoplasms 28 | 425
Schizophrenia 28 | 1,160
diabetes mellitus 28 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,291
oligodendroglioma 27 | 2,850
ulcerative colitis 26 | 1,819
cystic fibrosis 24 | 1,696
intraductal papillary-mucinous adenoma (IPMA) 24 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,989
juvenile dermatomyositis 24 | 1,187
non-small cell lung cancer 24 | 2,890
subependymal giant cell astrocytoma 24 | 2,287
Stomach Neoplasms 23 | 300
Vascular disease 23 | 319
astrocytic glioma 23 | 2,597
colon cancer 23 | 1,478
lung carcinoma 23 | 2,843
Kidney cancer 22 | 2,613
interstitial cystitis 22 | 2,312
Lung Neoplasms 21 | 232
Prostatic Neoplasms 21 | 495
primitive neuroectodermal tumor 21 | 3,035
Kidney disease 20 | 430
Multiple myeloma 20 | 1,332
ductal carcinoma in situ 20 | 1,745
group 4 medulloblastoma 20 | 1,855
lung adenocarcinoma 20 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 20 | 1,962
Liver carcinoma 19 | 240
dermatomyositis 19 | 966
group 3 medulloblastoma 19 | 4,104
nasopharyngeal carcinoma 19 | 1,058
Arthritis 18 | 290
Hypertensive disease 18 | 292
Liver Cirrhosis, Experimental 18 | 769
acute quadriplegic myopathy 18 | 1,158
breast carcinoma 18 | 1,638
pituitary cancer 18 | 1,972
Carcinoma, Hepatocellular 17 | 228
Hypertension 17 | 396
Short stature 17 | 531
esophageal adenocarcinoma 17 | 737
primary pancreatic ductal adenocarcinoma 17 | 1,109
Asthma 16 | 385
Rheumatoid arthritis 16 | 1,191
adrenocortical carcinoma 16 | 1,428
Reperfusion Injury 15 | 86
autosomal dominant Emery-Dreifuss muscular dystrophy 15 | 510
gastric carcinoma 15 | 807
Adenoma 14 | 167
Alzheimer's disease 14 | 658
Atopic dermatitis 14 | 952
Autosomal recessive predisposition 14 | 1,442
Bipolar Disorder 14 | 666
Duchenne muscular dystrophy 14 | 601
Heart disease 14 | 306
Multiple Sclerosis 14 | 540
spina bifida 14 | 1,074
Intellectual disability 13 | 1,016
Lung disease 13 | 142
Melanoma 13 | 711
Obesity 13 | 678
Osteoporosis 13 | 363
active Crohn's disease 13 | 922
astrocytoma 13 | 1,146
Anemia 12 | 365
Atherosclerosis 12 | 291
Bladder Neoplasm 12 | 112
Brain Ischemia 12 | 110
Chemical and Drug Induced Liver Injury 12 | 195
Endometriosis 12 | 540
Hypersensitivity reaction type II disease 12 | 253
Inflammatory bowel disease 12 | 151
Liver Cirrhosis 12 | 181
Mesothelioma, Malignant 12 | 105
Neoplasm Invasiveness 12 | 161
Urinary Bladder Neoplasms 12 | 114
Waldenstrons macroglobulinemia 12 | 765
active ulcerative colitis 12 | 764
cutaneous lupus erythematosus 12 | 1,057
gastric cancer 12 | 459
hepatocellular carcinoma 12 | 547

Tissue

Blood and immune system 105 | 16,909
Endocrine System 104 | 18,159
Digestive Tract 103 | 17,369
Female tissues 103 | 17,400
Liver and Pancreas 103 | 16,750
Male tissues 103 | 17,142
Respiratory system 103 | 16,393
Skin and soft tissues 103 | 17,230
Urinary Tract 103 | 16,678
Nervous System 102 | 16,725
Cardiovascular System 99 | 15,192

Target Family

Non-IDG 64 | 12,091
Kinase 13 | 634
Enzyme 11 | 4,145
Transcription Factor 11 | 1,400
Transporter 4 | 473
Epigenetic 3 | 242

WikiPathways Pathway

Senescence and Autophagy in Ca... 106 | 106
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Inhibitor of growth protein 1 ING1 Tbio Epigenetic -2.05417 130.8 341
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Interferon regulatory factor 5 IRF5 Tbio Transcription Factor -2.33923 241.0 400
Endophilin-B1 SH3GLB1 Tbio Non-IDG -1.10096 14.5 386
Fibronectin FN1 Tchem Non-IDG -3.09873 1208.8 1583
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
CCAAT/enhancer-binding protein beta CEBPB Tbio Transcription Factor -2.96589 857.9 436
Zinc transporter ZIP3 SLC39A3 Tbio Transporter -0.52290 3.15 87
Ribosomal L1 domain-containing protein 1 RSL1D1 Tbio Non-IDG -1.29068 21.3 116
Gamma-aminobutyric acid receptor-associated protein-like 1 GABARAPL1 Tbio Non-IDG -2.39692 232.7 211