Development Level

Tbio 41 | 11,445
Tchem 20 | 1,598
Tclin 15 | 613
Tdark 9 | 6,588

IMPC Phenotype

abnormal heart morphology 3 | 162
enlarged heart 3 | 210
preweaning lethality, complete... 3 | 979
abnormal testis morphology 2 | 43
decreased bone mineral content 2 | 151
decreased lean body mass 2 | 135
decreased vertical activity 2 | 208
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
increased circulating choleste... 2 | 66
increased total body fat amoun... 2 | 134
preweaning lethality, incomple... 2 | 499
small testis 2 | 58
abnormal behavior 1 | 298
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal snout morphology 1 | 23
abnormal spine curvature 1 | 9
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased cardiac muscle contr... 1 | 11
decreased circulating amylase ... 1 | 28
decreased circulating creatini... 1 | 39
decreased circulating insulin ... 1 | 76
decreased circulating magnesiu... 1 | 13
decreased circulating sodium l... 1 | 22
decreased circulating unsatura... 1 | 2
decreased heart rate 1 | 18
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased thermal nociceptive ... 1 | 2
decreased total body fat amoun... 1 | 207
enlarged epididymis 1 | 31
enlarged spleen 1 | 41
hydrometra 1 | 53
hypoactivity 1 | 132
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased circulating iron lev... 1 | 30
increased erythrocyte cell num... 1 | 39
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased thermal nociceptive ... 1 | 9
prenatal lethality prior to he... 1 | 87
prolonged PQ interval 1 | 5
prolonged QT interval 1 | 38
tremors 1 | 39
vertebral fusion 1 | 23

Disease

Cancer 49 | 2,499
Carcinoma 44 | 11,493
ovarian cancer 44 | 8,520
psoriasis 38 | 6,694
lung cancer 36 | 4,740
Atherosclerosis 34 | 291
diabetes mellitus 33 | 1,728
glioblastoma 30 | 5,792
osteosarcoma 30 | 7,950
lung carcinoma 29 | 2,843
Hypertension 28 | 396
pancreatic ductal adenocarcinoma liver metastasis 28 | 1,962
Schizophrenia 27 | 1,160
Coronary artery disease 25 | 268
Obesity 25 | 678
cystic fibrosis 25 | 1,696
pancreatic cancer 24 | 2,398
tuberculosis 24 | 2,010
adult high grade glioma 23 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 23 | 3,291
invasive ductal carcinoma 23 | 2,951
non-small cell lung cancer 23 | 2,890
ulcerative colitis 23 | 1,819
Hypertensive disease 22 | 292
Kidney disease 22 | 430
intraductal papillary-mucinous adenoma (IPMA) 22 | 2,955
malignant mesothelioma 22 | 3,232
Autosomal recessive predisposition 21 | 1,442
Cerebrovascular disease 20 | 238
Liver disease 20 | 237
ependymoma 20 | 4,679
Brain Ischemia 19 | 110
Breast cancer 19 | 3,578
lung adenocarcinoma 19 | 2,716
Alzheimer's disease 18 | 658
Anemia 18 | 365
Multiple myeloma 18 | 1,332
atypical teratoid / rhabdoid tumor 18 | 5,112
Asthma 17 | 385
Heart disease 17 | 306
Heart failure 17 | 162
Liver Cirrhosis, Experimental 17 | 769
Myocardial Infarction 17 | 151
Rheumatoid arthritis 17 | 1,191
interstitial cystitis 17 | 2,312
Astrocytoma, Pilocytic 16 | 3,081
Chemical and Drug Induced Liver Injury 16 | 195
Major Depressive Disorder 16 | 301
Prostatic Neoplasms 16 | 495
Reperfusion Injury 16 | 86
group 3 medulloblastoma 16 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
medulloblastoma, large-cell 16 | 6,241
Bipolar Disorder 15 | 666
Breast Neoplasms 15 | 445
Diabetes Mellitus, Experimental 15 | 108
Hyperglycemia 15 | 137
Lipid metabolism disorder 15 | 114
Mammary Neoplasms 15 | 425
Vascular disease 15 | 319
oligodendroglioma 15 | 2,850
periodontitis 15 | 293
Pancreatitis 14 | 123
Unipolar Depression 14 | 250
Arthritis 13 | 290
Arthritis, Rheumatoid 13 | 174
Cholestasis 13 | 155
Inflammation 13 | 120
Kidney Failure, Chronic 13 | 46
ductal carcinoma in situ 13 | 1,745
Cerebrovascular accident 12 | 63
Depressive disorder 12 | 409
Diabetes Mellitus, Non-Insulin-Dependent 12 | 145
Fatty liver disease 12 | 103
Lung Neoplasms 12 | 232
Lung disease 12 | 142
adrenocortical carcinoma 12 | 1,428
Dementia 11 | 175
Diarrhea 11 | 253
Endometriosis 11 | 540
Fatty Liver 11 | 70
Hyperhomocysteinemia 11 | 37
Hypersensitivity reaction type II disease 11 | 253
Hyperthyroidism 11 | 53
Hypotension 11 | 82
Mental Depression 11 | 333
Osteoporosis 11 | 363
Peripheral vascular disease 11 | 87
Peritonitis 11 | 43
Pulmonary embolism 11 | 55
Stomach Neoplasms 11 | 300
Stroke 11 | 33
acute quadriplegic myopathy 11 | 1,158
breast carcinoma 11 | 1,638
colon cancer 11 | 1,478
cutaneous lupus erythematosus 11 | 1,057
primary pancreatic ductal adenocarcinoma 11 | 1,109
sarcoidosis 11 | 370
Down syndrome 10 | 499
Kidney cancer 10 | 2,613

Tissue

Endocrine System 84 | 18,159
Digestive Tract 82 | 17,369
Male tissues 82 | 17,142
Urinary Tract 82 | 16,678
Female tissues 81 | 17,400
Liver and Pancreas 81 | 16,750
Skin and soft tissues 79 | 17,230
Blood and immune system 78 | 16,909
Respiratory system 78 | 16,393
Nervous System 77 | 16,725
Cardiovascular System 71 | 15,192

Target Family

Enzyme 44 | 4,145
Non-IDG 36 | 12,091
Transcription Factor 3 | 1,400
Kinase 1 | 634
Transporter 1 | 473

WikiPathways Pathway

Selenium Micronutrient Network 85 | 85
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Selenoprotein M SELENOM Tdark Non-IDG -1.51502 30.3 0
Pyridoxine-5'-phosphate oxidase PNPO Tchem Enzyme -1.95803 90.7 200
Thioredoxin reductase 3 TXNRD3 Tdark Enzyme -1.72626 60.0 0
Methylenetetrahydrofolate reductase MTHFR Tbio Enzyme -3.68447 5032.2 275
Methionine synthase MTR Tbio Enzyme -2.56900 300.2 87
Selenide, water dikinase 2 SEPHS2 Tdark Enzyme -1.42671 25.3 0
Scavenger receptor class B member 1 SCARB1 Tchem Non-IDG -2.93920 915.7 378
Selenoprotein W SELENOW Tbio Non-IDG -1.83127 70.7 63
Alpha-1-antichymotrypsin SERPINA3 Tbio Non-IDG -2.94780 812.7 276
Cystathionine beta-synthase-like protein CBS Tbio Non-IDG -3.25635 3246.1 0