Development Level

Tbio 30 | 11,445
Tdark 8 | 6,588
Tchem 6 | 1,598
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal retina morphology 2 | 71
abnormal behavior 1 | 298
abnormal cornea morphology 1 | 31
abnormal epididymis morphology 1 | 42
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal skin condition 1 | 6
abnormal spine curvature 1 | 9
abnormal testis morphology 1 | 43
cataract 1 | 92
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating creatini... 1 | 39
decreased circulating insulin ... 1 | 76
decreased circulating magnesiu... 1 | 13
decreased circulating sodium l... 1 | 22
decreased grip strength 1 | 116
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular hem... 1 | 31
decreased thermal nociceptive ... 1 | 2
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
hydrometra 1 | 53
hypoactivity 1 | 132
increased NK cell number 1 | 3
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased circulating free fat... 1 | 20
increased circulating insulin ... 1 | 3
increased leukocyte cell numbe... 1 | 47
increased or absent threshold ... 1 | 101
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
prenatal lethality prior to he... 1 | 87
small testis 1 | 58
vertebral fusion 1 | 23

Disease

Carcinoma 25 | 11,493
ovarian cancer 25 | 8,520
osteosarcoma 23 | 7,950
Cancer 16 | 2,499
glioblastoma 16 | 5,792
lung cancer 15 | 4,740
psoriasis 15 | 6,694
atypical teratoid / rhabdoid tumor 14 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
medulloblastoma, large-cell 13 | 6,241
Schizophrenia 12 | 1,160
group 3 medulloblastoma 12 | 4,104
tuberculosis 12 | 2,010
adult high grade glioma 10 | 3,801
colon cancer 10 | 1,478
diabetes mellitus 10 | 1,728
Multiple myeloma 9 | 1,332
ependymoma 9 | 4,679
lung adenocarcinoma 9 | 2,716
malignant mesothelioma 9 | 3,232
non-small cell lung cancer 9 | 2,890
pancreatic cancer 9 | 2,398
primitive neuroectodermal tumor 9 | 3,035
group 4 medulloblastoma 8 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
Breast Neoplasms 7 | 445
Liver Cirrhosis, Experimental 7 | 769
Mammary Neoplasms 7 | 425
Staphyloenterotoxemia 7 | 18
acute quadriplegic myopathy 7 | 1,158
adrenocortical carcinoma 7 | 1,428
astrocytic glioma 7 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
invasive ductal carcinoma 7 | 2,951
lung carcinoma 7 | 2,843
oligodendroglioma 7 | 2,850
Hypertension 6 | 396
Keshan disease 6 | 17
Lung Neoplasms 6 | 232
Obesity 6 | 678
ulcerative colitis 6 | 1,819
Astrocytoma, Pilocytic 5 | 3,081
Autosomal recessive predisposition 5 | 1,442
Breast cancer 5 | 3,578
Cell Transformation, Neoplastic 5 | 97
Epilepsy 5 | 792
Hyperthyroidism 5 | 53
Pick disease 5 | 1,894
Prostatic Neoplasms 5 | 495
breast carcinoma 5 | 1,638
gastric carcinoma 5 | 807
pituitary cancer 5 | 1,972
primary pancreatic ductal adenocarcinoma 5 | 1,109
Brain Ischemia 4 | 110
Colorectal Neoplasms 4 | 243
Endometriosis 4 | 540
Heat Stroke 4 | 13
Hyperglycemia 4 | 137
Hypertensive disease 4 | 292
Hypothyroidism 4 | 122
Kidney disease 4 | 430
Liver neoplasms 4 | 130
Neoplastic Cell Transformation 4 | 89
Reperfusion Injury 4 | 86
Toxic encephalopathy 4 | 141
Vascular disease 4 | 319
Waldenstrons macroglobulinemia 4 | 765
active Crohn's disease 4 | 922
astrocytoma 4 | 1,146
ductal carcinoma in situ 4 | 1,745
esophageal adenocarcinoma 4 | 737
fibroadenoma 4 | 559
hepatocellular carcinoma 4 | 547
non primary Sjogren syndrome sicca 4 | 891
pediatric high grade glioma 4 | 1,064
posterior fossa group A ependymoma 4 | 468
Adenoma 3 | 167
Alzheimer's disease 3 | 658
Arthritis, Juvenile 3 | 126
Carcinoma, Hepatocellular 3 | 228
Cerebrovascular disease 3 | 238
Diabetes Mellitus, Non-Insulin-Dependent 3 | 145
Diabetes Mellitus, Type 2 3 | 142
Down syndrome 3 | 499
Inflammatory bowel disease 3 | 151
Juvenile arthritis 3 | 126
Liver carcinoma 3 | 240
Major Depressive Disorder 3 | 301
Male infertility 3 | 206
Psychotic Disorders 3 | 151
Rheumatoid arthritis 3 | 1,191
active ulcerative colitis 3 | 764
acute myeloid leukemia 3 | 783
cutaneous lupus erythematosus 3 | 1,057
cystic fibrosis 3 | 1,696
gastric cancer 3 | 459
nephrosclerosis 3 | 333
pancreatic carcinoma 3 | 562
pterygium 3 | 76

Tissue

Endocrine System 46 | 18,159
Male tissues 46 | 17,142
Blood and immune system 45 | 16,909
Female tissues 45 | 17,400
Liver and Pancreas 45 | 16,750
Nervous System 45 | 16,725
Digestive Tract 44 | 17,369
Respiratory system 44 | 16,393
Skin and soft tissues 44 | 17,230
Urinary Tract 44 | 16,678
Cardiovascular System 41 | 15,192

Target Family

Enzyme 20 | 4,145
Non-IDG 16 | 12,091
Transcription Factor 9 | 1,400
Kinase 1 | 634

WikiPathways Pathway

Selenium Metabolism and Seleno... 46 | 46
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Selenide, water dikinase 2 SEPHS2 Tdark Enzyme -1.42671 25.3 0
O-phosphoseryl-tRNA(Sec) selenium transferase SEPSECS Tbio Enzyme -2.11362 120.5 120
Thioredoxin reductase 3 TXNRD3 Tdark Enzyme -1.72626 60.0 0
Selenoprotein M SELENOM Tdark Non-IDG -1.51502 30.3 0
Selenoprotein K SELENOK Tbio Non-IDG -1.39537 26.6 0
Selenoprotein W SELENOW Tbio Non-IDG -1.83127 70.7 63
Selenoprotein N SELENON Tbio Non-IDG -1.95384 87.6 96
Methionine-R-sulfoxide reductase B1 MSRB1 Tbio Enzyme -1.56033 39.8 64
Selenoprotein H SELENOH Tdark Non-IDG -1.52303 0.00000 8
Type I iodothyronine deiodinase DIO1 Tclin Enzyme -2.19858 153.3 82