Development Level

Tchem 9 | 1,598
Tclin 4 | 613
Tbio 3 | 11,445

IMPC Phenotype

increased circulating choleste... 2 | 66
abnormal embryo size 1 | 220
abnormal heart left ventricle ... 1 | 16
abnormal kidney morphology 1 | 65
abnormal seminal vesicle morph... 1 | 114
decreased blood urea nitrogen ... 1 | 51
decreased circulating LDL chol... 1 | 38
decreased circulating unsatura... 1 | 2
decreased heart weight 1 | 27
decreased vertical activity 1 | 208
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating iron lev... 1 | 30
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased startle reflex 1 | 112
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 16 | 11,493
Obesity 12 | 678
osteosarcoma 12 | 7,950
diabetes mellitus 11 | 1,728
ovarian cancer 11 | 8,520
Atherosclerosis 10 | 291
Fatty liver disease 9 | 103
Cancer 8 | 2,499
Lipid metabolism disorder 8 | 114
Schizophrenia 8 | 1,160
glioblastoma 8 | 5,792
psoriasis 8 | 6,694
atypical teratoid / rhabdoid tumor 7 | 5,112
ductal carcinoma in situ 7 | 1,745
malignant mesothelioma 7 | 3,232
medulloblastoma, large-cell 7 | 6,241
Alzheimer's disease 6 | 658
Breast cancer 6 | 3,578
Carcinoma, Hepatocellular 6 | 228
Kidney Failure, Chronic 6 | 46
Liver carcinoma 6 | 240
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
invasive ductal carcinoma 6 | 2,951
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
Fatty Liver 5 | 70
Hyperglycemia 5 | 137
Insulin Resistance 5 | 72
Pick disease 5 | 1,894
oligodendroglioma 5 | 2,850
Coronary artery disease 4 | 268
Diabetes Mellitus, Experimental 4 | 108
Hypercholesterolemia 4 | 44
Hyperlipidemia 4 | 43
Kidney cancer 4 | 2,613
Non-alcoholic Fatty Liver Disease 4 | 42
Parkinson's disease 4 | 392
Vascular disease 4 | 319
active ulcerative colitis 4 | 764
acute quadriplegic myopathy 4 | 1,158
adrenocortical carcinoma 4 | 1,428
astrocytic glioma 4 | 2,597
group 3 medulloblastoma 4 | 4,104
lung carcinoma 4 | 2,843
non-small cell lung cancer 4 | 2,890
pituitary cancer 4 | 1,972
subependymal giant cell astrocytoma 4 | 2,287
Cardiovascular system disease 3 | 246
Chemical and Drug Induced Liver Injury 3 | 195
Diabetes Mellitus, Non-Insulin-Dependent 3 | 145
Diabetes Mellitus, Type 2 3 | 142
Heart failure 3 | 162
Hydrolethalus syndrome 3 | 128
Hypertensive disease 3 | 292
Liver Cirrhosis, Experimental 3 | 769
Metabolic syndrome X 3 | 52
Myocardial Infarction 3 | 151
active Crohn's disease 3 | 922
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
chronic rhinosinusitis 3 | 512
colon cancer 3 | 1,478
cystic fibrosis 3 | 1,696
ependymoma 3 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
lung cancer 3 | 4,740
pancreatic cancer 3 | 2,398
posterior fossa group B ependymoma 3 | 416
tuberculosis 3 | 2,010
ulcerative colitis 3 | 1,819
Anemia 2 | 365
Angina Pectoris 2 | 32
Animal Mammary Neoplasms 2 | 136
Autoimmune Diseases 2 | 67
Breast Neoplasms 2 | 445
Down syndrome 2 | 499
Gaucher disease type 1 2 | 180
Globe disease 2 | 67
Heart disease 2 | 306
Hepatomegaly 2 | 285
Huntington's disease 2 | 76
Hypertension 2 | 396
Kidney disease 2 | 430
Liver cancer 2 | 604
Liver disease 2 | 237
Liver neoplasms 2 | 130
Mammary Neoplasms 2 | 425
Mammary Neoplasms, Animal 2 | 136
Mammary Neoplasms, Experimental 2 | 154
Muscular Diseases 2 | 27
Myopathy 2 | 185
Nerve Degeneration 2 | 121
Stomach Neoplasms 2 | 300
Toxic encephalopathy 2 | 141
atypical teratoid/rhabdoid tumor 2 | 357
lung adenocarcinoma 2 | 2,716
pancreatic carcinoma 2 | 562
pediatric high grade glioma 2 | 1,064
progressive supranuclear palsy 2 | 676
sarcoidosis 2 | 370
spina bifida 2 | 1,074

Tissue

Blood and immune system 16 | 16,909
Cardiovascular System 16 | 15,192
Digestive Tract 16 | 17,369
Endocrine System 16 | 18,159
Female tissues 16 | 17,400
Liver and Pancreas 16 | 16,750
Male tissues 16 | 17,142
Nervous System 16 | 16,725
Respiratory system 16 | 16,393
Skin and soft tissues 16 | 17,230
Urinary Tract 16 | 16,678

Target Family

Enzyme 5 | 4,145
Epigenetic 2 | 242
Kinase 2 | 634
Non-IDG 2 | 12,091
Nuclear Receptor 2 | 48
Transcription Factor 2 | 1,400
Transporter 1 | 473

WikiPathways Pathway

SREBF and miR33 in cholesterol... 16 | 16
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mediator of RNA polymerase II transcription subunit 15 MED15 Tbio Enzyme -1.60315 40.6 144
Hydroxymethylglutaryl-CoA synthase, cytoplasmic HMGCS1 Tchem Enzyme -1.67608 43.7 137
Sterol regulatory element-binding protein 2 SREBF2 Tchem Transcription Factor -2.61148 361.0 205
Low-density lipoprotein receptor LDLR Tchem Non-IDG -3.06808 938.9 585
Sterol regulatory element-binding protein 1 SREBF1 Tbio Transcription Factor -3.12075 1267.4 429
Peroxisome proliferator-activated receptor alpha PPARA Tclin Nuclear Receptor -3.37176 2457.9 501
Fatty acid synthase FASN Tchem Enzyme -2.61118 400.6 468
ATP-binding cassette sub-family A member 1 ABCA1 Tclin Transporter -3.15111 1451.8 388
3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR Tclin Enzyme -3.21450 1428.4 229
Serine/threonine-protein kinase mTOR MTOR Tclin Kinase -3.89596 7790.5 1195