Development Level

Tbio 50 | 11,445
Tchem 24 | 1,598
Tclin 13 | 613

IMPC Phenotype

preweaning lethality, complete... 12 | 979
embryonic lethality prior to o... 9 | 239
embryonic lethality prior to t... 6 | 278
abnormal embryo size 3 | 220
abnormal lens morphology 2 | 81
cataract 2 | 92
decreased lean body mass 2 | 135
decreased mean corpuscular hem... 2 | 50
female infertility 2 | 60
male infertility 2 | 123
prenatal lethality prior to he... 2 | 87
abnormal coat-hair pigmentatio... 1 | 64
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
abnormal lung morphology 1 | 26
abnormal maxilla morphology 1 | 17
abnormal pericardium morpholog... 1 | 26
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
cardiovascular system phenotyp... 1 | 36
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased mean corpuscular vol... 1 | 79
decreased total body fat amoun... 1 | 207
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
hyperactivity 1 | 148
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased grip strength 1 | 41
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 92
microphthalmia 1 | 26
preweaning lethality, incomple... 1 | 499
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74
small testis 1 | 58
urinary bladder obstruction 1 | 4

Disease

ovarian cancer 67 | 8,520
group 3 medulloblastoma 63 | 4,104
Carcinoma 61 | 11,493
Cancer 57 | 2,499
glioblastoma 56 | 5,792
psoriasis 56 | 6,694
Breast cancer 54 | 3,578
lung cancer 54 | 4,740
medulloblastoma, large-cell 54 | 6,241
atypical teratoid / rhabdoid tumor 53 | 5,112
osteosarcoma 53 | 7,950
primitive neuroectodermal tumor 50 | 3,035
malignant mesothelioma 48 | 3,232
non-small cell lung cancer 44 | 2,890
adrenocortical carcinoma 42 | 1,428
intraductal papillary-mucinous neoplasm (IPMN) 40 | 3,291
ependymoma 37 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 34 | 2,989
adult high grade glioma 33 | 3,801
invasive ductal carcinoma 33 | 2,951
ductal carcinoma in situ 32 | 1,745
lung adenocarcinoma 31 | 2,716
nasopharyngeal carcinoma 30 | 1,058
colon cancer 25 | 1,478
Endometriosis 24 | 540
breast carcinoma 23 | 1,638
oligodendroglioma 21 | 2,850
Astrocytoma, Pilocytic 19 | 3,081
Waldenstrons macroglobulinemia 19 | 765
Atopic dermatitis 18 | 952
pancreatic cancer 18 | 2,398
Kidney cancer 17 | 2,613
astrocytoma 17 | 1,146
Breast Neoplasms 16 | 445
Mammary Neoplasms 16 | 425
subependymal giant cell astrocytoma 16 | 2,287
pediatric high grade glioma 14 | 1,064
tuberculosis 14 | 2,010
Carcinoma, Hepatocellular 13 | 228
Liver carcinoma 13 | 240
dermatomyositis 13 | 966
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
primary Sjogren syndrome 13 | 735
Intellectual disability 12 | 1,016
acute quadriplegic myopathy 12 | 1,158
Autosomal recessive predisposition 11 | 1,442
Multiple myeloma 11 | 1,332
Prostatic Neoplasms 11 | 495
Small head 11 | 374
astrocytic glioma 11 | 2,597
pituitary cancer 11 | 1,972
Cognitive delay 10 | 608
Dull intelligence 10 | 645
Fetal Growth Retardation 10 | 189
Global developmental delay 10 | 608
Low intelligence 10 | 645
Lung Neoplasms 10 | 232
Mental Retardation 10 | 645
Mental and motor retardation 10 | 608
Mental deficiency 10 | 645
Poor school performance 10 | 645
Rheumatoid arthritis 10 | 1,191
Short stature 10 | 531
Stomach Neoplasms 10 | 300
interstitial cystitis 10 | 2,312
juvenile dermatomyositis 10 | 1,187
ulcerative colitis 10 | 1,819
Infant, Small for Gestational Age 9 | 176
Intrauterine retardation 9 | 176
Polycystic ovary syndrome 9 | 360
Adenocarcinoma of lung 8 | 142
Colonic Neoplasms 8 | 142
Schizophrenia 8 | 1,160
acute myeloid leukemia 8 | 783
esophageal adenocarcinoma 8 | 737
Colorectal Neoplasms 7 | 243
Cryptorchidism 7 | 296
Disease Models, Animal 7 | 155
Mesothelioma, Malignant 7 | 105
active Crohn's disease 7 | 922
progressive supranuclear palsy 7 | 676
Adenoid Cystic Carcinoma 6 | 99
Adenoma 6 | 167
Bladder Neoplasm 6 | 112
Carcinoma, Adenoid Cystic 6 | 99
Endometrial cancer 6 | 311
Hypoplastic mandible condyle 6 | 275
Leukemia 6 | 104
Liver Cirrhosis, Experimental 6 | 769
Liver neoplasms 6 | 130
Mammary Neoplasms, Experimental 6 | 154
Mandibular hypoplasia 6 | 275
Micrognathism 6 | 275
Pick disease 6 | 1,894
Squamous cell carcinoma 6 | 129
Urinary Bladder Neoplasms 6 | 114
lung carcinoma 6 | 2,843
medulloblastoma 6 | 720
non-small cell lung carcinoma 6 | 317
primary pancreatic ductal adenocarcinoma 6 | 1,109

Tissue

Blood and immune system 87 | 16,909
Digestive Tract 87 | 17,369
Endocrine System 87 | 18,159
Female tissues 87 | 17,400
Liver and Pancreas 87 | 16,750
Male tissues 87 | 17,142
Nervous System 87 | 16,725
Respiratory system 87 | 16,393
Skin and soft tissues 87 | 17,230
Urinary Tract 87 | 16,678
Cardiovascular System 86 | 15,192

Target Family

Non-IDG 39 | 12,091
Enzyme 19 | 4,145
Kinase 14 | 634
Transcription Factor 10 | 1,400
Epigenetic 5 | 242

WikiPathways Pathway

Retinoblastoma (RB) in Cancer 87 | 87
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Origin recognition complex subunit 1 ORC1 Tbio Non-IDG -1.42573 28.0 148
DNA (cytosine-5)-methyltransferase 1 DNMT1 Tclin Enzyme -3.21333 1562.7 1125
Thymidylate synthase TYMS Tclin Enzyme -2.93426 732.0 733
Structural maintenance of chromosomes protein 3 SMC3 Tbio Non-IDG -2.10209 115.2 244
DNA topoisomerase 2-alpha TOP2A Tclin Enzyme -2.88264 723.0 847
Replication factor C subunit 3 RFC3 Tbio Non-IDG -1.30866 19.7 176
Replication protein A 14 kDa subunit RPA3 Tbio Non-IDG -1.85941 67.1 171
Dihydrofolate reductase DHFR Tclin Enzyme -2.99192 972.8 202
High mobility group protein B2 HMGB2 Tbio Transcription Factor -1.52510 34.5 267
DNA mismatch repair protein Msh6 MSH6 Tbio Epigenetic -2.72594 572.3 479