Development Level

Tbio 71 | 11,445
Tchem 47 | 1,598
Tclin 16 | 613
Tdark 4 | 6,588

IMPC Phenotype

preweaning lethality, complete... 8 | 979
decreased body weight 5 | 161
preweaning lethality, incomple... 4 | 499
abnormal bone structure 3 | 187
decreased circulating creatini... 3 | 39
decreased mean corpuscular vol... 3 | 79
decreased vertical activity 3 | 208
embryonic lethality prior to t... 3 | 278
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
abnormal gait 2 | 69
decreased circulating choleste... 2 | 93
decreased circulating triglyce... 2 | 79
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular hem... 2 | 31
decreased total body fat amoun... 2 | 207
embryonic growth retardation 2 | 106
enlarged heart 2 | 210
increased circulating alkaline... 2 | 122
increased lean body mass 2 | 172
increased lymphocyte cell numb... 2 | 32
increased neutrophil cell numb... 2 | 46
increased total body fat amoun... 2 | 134
small superior vagus ganglion 2 | 74
abnormal bone mineralization 1 | 38
abnormal cecum morphology 1 | 7
abnormal cornea morphology 1 | 31
abnormal epididymis morphology 1 | 42
abnormal glucose homeostasis 1 | 4
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal spleen morphology 1 | 55
abnormal vibrissa morphology 1 | 25
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating magnesiu... 1 | 13
decreased circulating sodium l... 1 | 22
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased heart weight 1 | 27
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased monocyte cell number 1 | 8
decreased neutrophil cell numb... 1 | 42
decreased thermal nociceptive ... 1 | 2
embryonic lethality prior to o... 1 | 239
enlarged cecum 1 | 5
enlarged epididymis 1 | 31
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
enlarged uterus 1 | 11
hypoactivity 1 | 132
impaired righting response 1 | 26
increased CD4-positive, alpha ... 1 | 4
increased body length 1 | 32
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased eosinophil cell numb... 1 | 11
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased thermal nociceptive ... 1 | 9
male infertility 1 | 123
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
thrombocytosis 1 | 27
vertebral fusion 1 | 23

Disease

Carcinoma 89 | 11,493
Cancer 79 | 2,499
ovarian cancer 69 | 8,520
psoriasis 67 | 6,694
glioblastoma 66 | 5,792
lung cancer 59 | 4,740
osteosarcoma 59 | 7,950
medulloblastoma, large-cell 46 | 6,241
tuberculosis 45 | 2,010
adult high grade glioma 43 | 3,801
atypical teratoid / rhabdoid tumor 40 | 5,112
lung carcinoma 38 | 2,843
Astrocytoma, Pilocytic 35 | 3,081
malignant mesothelioma 34 | 3,232
Arthritis 33 | 290
ependymoma 32 | 4,679
non-small cell lung cancer 32 | 2,890
Asthma 31 | 385
diabetes mellitus 31 | 1,728
Breast cancer 30 | 3,578
Influenza 30 | 142
Multiple Sclerosis 30 | 540
interstitial cystitis 30 | 2,312
invasive ductal carcinoma 30 | 2,951
cutaneous lupus erythematosus 29 | 1,057
Rheumatoid arthritis 28 | 1,191
subependymal giant cell astrocytoma 28 | 2,287
ulcerative colitis 28 | 1,819
lung adenocarcinoma 26 | 2,716
Hypersensitivity reaction type II disease 24 | 253
Schizophrenia 24 | 1,160
cystic fibrosis 24 | 1,696
Inflammatory bowel disease 23 | 151
intraductal papillary-mucinous carcinoma (IPMC) 23 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 23 | 3,291
pancreatic cancer 23 | 2,398
Pneumonia 22 | 174
Kidney cancer 21 | 2,613
juvenile dermatomyositis 21 | 1,187
Lung disease 20 | 142
Vascular disease 20 | 319
group 4 medulloblastoma 20 | 1,855
pituitary cancer 20 | 1,972
Kidney disease 19 | 430
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,955
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,962
Reperfusion Injury 18 | 86
breast carcinoma 18 | 1,638
Breast Neoplasms 17 | 445
Lung Neoplasms 17 | 232
Mammary Neoplasms 17 | 425
group 3 medulloblastoma 17 | 4,104
Dermatitis 16 | 157
Liver Cirrhosis, Experimental 16 | 769
Liver disease 16 | 237
Malaria 16 | 160
Obesity 16 | 678
hepatocellular carcinoma 16 | 547
primitive neuroectodermal tumor 16 | 3,035
Allergic hypersensitivity disease 15 | 126
Autosomal recessive predisposition 15 | 1,442
Liver carcinoma 15 | 240
dermatomyositis 15 | 966
Atherosclerosis 14 | 291
Brain Ischemia 14 | 110
Hepatitis C 14 | 94
Multiple myeloma 14 | 1,332
active Crohn's disease 14 | 922
acute myeloid leukemia 14 | 783
ductal carcinoma in situ 14 | 1,745
primary Sjogren syndrome 14 | 735
Bipolar Disorder 13 | 666
Carcinoma, Hepatocellular 13 | 228
Cholestasis, Extrahepatic 13 | 25
Depressive disorder 13 | 409
Hepatitis B 13 | 108
Human immunodeficiency virus infectious disease 13 | 138
Immunologic Deficiency Syndromes 13 | 113
Inflammation 13 | 120
Meningitis 13 | 67
Seizures 13 | 596
active ulcerative colitis 13 | 764
pancreatic carcinoma 13 | 562
Arthritis, Rheumatoid 12 | 174
Brain Injuries 12 | 65
Diarrhea 12 | 253
Encephalitis 12 | 64
Neoplasm Metastasis 12 | 168
Prostatic Neoplasms 12 | 495
Systemic lupus erythematosus 12 | 194
colon cancer 12 | 1,478
nasopharyngeal carcinoma 12 | 1,058
oligodendroglioma 12 | 2,850
Coronary artery disease 11 | 268
Epilepsy 11 | 792
Hypertension 11 | 396
Osteoporosis 11 | 363
Pick disease 11 | 1,894
Stomach Neoplasms 11 | 300
adrenocortical carcinoma 11 | 1,428

Tissue

Blood and immune system 127 | 16,909
Male tissues 126 | 17,142
Liver and Pancreas 125 | 16,750
Nervous System 125 | 16,725
Urinary Tract 125 | 16,678
Digestive Tract 124 | 17,369
Endocrine System 124 | 18,159
Female tissues 124 | 17,400
Skin and soft tissues 124 | 17,230
Respiratory system 123 | 16,393
Cardiovascular System 118 | 15,192

Target Family

Non-IDG 72 | 12,091
Kinase 39 | 634
Enzyme 16 | 4,145
Transcription Factor 10 | 1,400
Epigenetic 1 | 242

WikiPathways Pathway

Regulation of toll-like recept... 138 | 138
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E3 ubiquitin-protein ligase RNF216 RNF216 Tbio Enzyme -1.27012 17.8 170
TIR domain-containing adapter molecule 2 TICAM2 Tbio Non-IDG -1.18212 14.6 258
Interferon regulatory factor 5 IRF5 Tbio Transcription Factor -2.33923 241.0 400
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Mothers against decapentaplegic homolog 6 SMAD6 Tbio Transcription Factor -2.07569 106.7 450
Sterile alpha and TIR motif-containing protein 1 SARM1 Tbio Non-IDG -2.22753 163.9 159
Lymphocyte antigen 96 LY96 Tchem Non-IDG -2.77678 541.2 369
Toll-like receptor 7 TLR7 Tclin Non-IDG -3.02761 1078.4 759
Lipopolysaccharide-binding protein LBP Tbio Non-IDG -2.61682 357.2 225
Triggering receptor expressed on myeloid cells 1 TREM1 Tbio Non-IDG -2.50690 350.6 473