Development Level

Tbio 13 | 11,651
Tchem 2 | 1,388

IMPC Phenotype

preweaning lethality, complete... 2 | 979
small testis 2 | 58
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal seminal vesicle morph... 1 | 114
abnormal testis morphology 1 | 43
cataract 1 | 92
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating glucose ... 1 | 126
decreased heart left ventricle... 1 | 28
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
decreased total body fat amoun... 1 | 207
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
impaired glucose tolerance 1 | 75
increased circulating HDL chol... 1 | 80
increased circulating glucose ... 1 | 24
increased fasted circulating g... 1 | 76
small kidney 1 | 16
small spleen 1 | 19

Disease

glioblastoma 12 | 5,792
primitive neuroectodermal tumor 12 | 3,035
Carcinoma 11 | 11,493
group 3 medulloblastoma 11 | 4,104
medulloblastoma, large-cell 11 | 6,241
ovarian cancer 11 | 8,520
Breast cancer 10 | 3,578
lung cancer 10 | 4,740
psoriasis 10 | 6,694
Cancer 9 | 2,499
adrenocortical carcinoma 9 | 1,428
atypical teratoid / rhabdoid tumor 9 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
invasive ductal carcinoma 9 | 2,951
lung adenocarcinoma 9 | 2,716
osteosarcoma 9 | 7,950
Intellectual disability 8 | 1,016
adult high grade glioma 8 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
non-small cell lung cancer 8 | 2,890
Atopic dermatitis 7 | 952
Hypoplastic mandible condyle 7 | 275
Mandibular hypoplasia 7 | 275
Micrognathism 7 | 275
Short stature 7 | 531
Small head 7 | 374
ependymoma 7 | 4,679
malignant mesothelioma 7 | 3,232
Cognitive delay 6 | 608
Dull intelligence 6 | 645
Endometriosis 6 | 540
Global developmental delay 6 | 608
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental and motor retardation 6 | 608
Mental deficiency 6 | 645
Poor school performance 6 | 645
colon cancer 6 | 1,478
ductal carcinoma in situ 6 | 1,745
pancreatic cancer 6 | 2,398
Fetal Growth Retardation 5 | 189
Infant, Small for Gestational Age 5 | 176
Intrauterine retardation 5 | 176
Kidney cancer 5 | 2,613
breast carcinoma 5 | 1,638
nasopharyngeal carcinoma 5 | 1,058
Anteverted nostril 4 | 191
Bilateral fifth finger clinodactyly 4 | 110
Brachycephaly 4 | 88
Broad cranium shape 4 | 88
Concave bridge of nose 4 | 195
Congenital hypoplasia of penis 4 | 176
Cornelia de Lange syndrome 4 | 21
Cryptorchidism 4 | 296
Curvature of little finger 4 | 110
Delayed bone age 4 | 136
Depressed nasal bridge 4 | 195
Depressed nasal root/bridge 4 | 195
Feeding difficulties in infancy 4 | 175
Glaucoma 4 | 239
Hypoplastic feet 4 | 66
KBG syndrome 4 | 9
Long philtrum 4 | 137
Penile hypospadias 4 | 106
Short neck 4 | 140
Short nose 4 | 132
Small hand 4 | 36
Small nose 4 | 132
Wide skull shape 4 | 88
oligodendroglioma 4 | 2,850
primary Sjogren syndrome 4 | 735
Absent auditory canals 3 | 23
Absent external auditory canals 3 | 23
Atresia of the external auditory canal 3 | 23
Atretic auditory canal 3 | 23
Attention deficit hyperactivity disorder 3 | 278
Bilateral single transverse palmar creases 3 | 34
Blepharoptosis 3 | 231
Byzanthine arch palate 3 | 194
Clouding of corneal stroma 3 | 50
Congenital Epicanthus 3 | 177
Corneal Opacity 3 | 53
Failure to gain weight 3 | 365
Gastroesophageal reflux disease 3 | 110
Heartburn 3 | 78
Leukemia, Myeloid 3 | 18
Micromelia 3 | 58
Muscle Hypertonia 3 | 88
Muscle biopsy shows dystrophic changes 3 | 39
Muscular dystrophy 3 | 75
Myeloid Leukemia 3 | 19
Myopia 3 | 176
Pediatric failure to thrive 3 | 365
Polyhydramnios 3 | 108
Severe mental retardation (I.Q. 20-34) 3 | 99
Speech Disorders 3 | 58
Syndactyly of the toes 3 | 45
Thin lips 3 | 49
Triangular face 3 | 58
pediatric high grade glioma 3 | 1,064

Tissue

Blood and immune system 15 | 16,909
Digestive Tract 15 | 17,369
Endocrine System 15 | 18,159
Female tissues 15 | 17,400
Liver and Pancreas 15 | 16,750
Male tissues 15 | 17,142
Nervous System 15 | 16,725
Respiratory system 15 | 16,393
Skin and soft tissues 15 | 17,230
Urinary Tract 15 | 16,678
Cardiovascular System 14 | 15,192

Target Family

Non-IDG 10 | 12,091
Enzyme 3 | 4,145
Kinase 2 | 634

WikiPathways Pathway

Regulation of sister chromatid... 15 | 15
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Securin PTTG1 Tbio Non-IDG -2.42127 261.4 311
Mitotic checkpoint serine/threonine-protein kinase BUB1 BUB1 Tchem Kinase -2.31533 200.0 373
Mitotic checkpoint protein BUB3 BUB3 Tbio Non-IDG -1.93368 76.1 256
Cell division cycle protein 20 homolog CDC20 Tbio Non-IDG -2.60409 401.5 393
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta BUB1B Tbio Kinase -2.50682 309.1 479
Structural maintenance of chromosomes protein 3 SMC3 Tbio Non-IDG -2.10209 115.2 244
Cohesin subunit SA-1 STAG1 Tbio Non-IDG -2.47449 292.2 200
Anaphase-promoting complex subunit 11 ANAPC11 Tbio Enzyme -1.27406 17.9 239
Anaphase-promoting complex subunit 2 ANAPC2 Tbio Enzyme -0.45557 2.44 166
Mitotic spindle assembly checkpoint protein MAD1 MAD1L1 Tbio Non-IDG -1.17500 13.6 283