Development Level

Tchem 21 | 1,598
Tbio 20 | 11,445
Tclin 5 | 613

Collection

Kinase: IDG Consortium (Comple... 2 | 37
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

abnormal bone structure 4 | 187
preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
abnormal retina morphology 2 | 71
decreased bone mineral content 2 | 151
increased circulating alkaline... 2 | 122
abnormal behavioral response t... 1 | 66
abnormal clavicle morphology 1 | 6
abnormal cranium morphology 1 | 36
abnormal femur morphology 1 | 14
abnormal joint morphology 1 | 23
abnormal optic disc morphology 1 | 10
abnormal skin coloration 1 | 25
abnormal sleep behavior 1 | 70
convulsive seizures 1 | 13
decreased anxiety-related resp... 1 | 12
decreased body length 1 | 101
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased neutrophil cell numb... 1 | 42
decreased spleen weight 1 | 10
decreased total body fat amoun... 1 | 207
edema 1 | 59
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged kidney 1 | 14
hyperactivity 1 | 148
hypoactivity 1 | 132
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral content 1 | 108
increased circulating chloride... 1 | 41
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
increased total body fat amoun... 1 | 134
polycystic kidney 1 | 15
preweaning lethality, complete... 1 | 979
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
short tibia 1 | 97

Disease

Carcinoma 40 | 11,493
ovarian cancer 30 | 8,520
medulloblastoma, large-cell 26 | 6,241
osteosarcoma 26 | 7,950
atypical teratoid / rhabdoid tumor 25 | 5,112
glioblastoma 25 | 5,792
Cancer 24 | 2,499
psoriasis 24 | 6,694
adult high grade glioma 22 | 3,801
ependymoma 22 | 4,679
lung cancer 21 | 4,740
Breast cancer 19 | 3,578
Kidney cancer 17 | 2,613
group 3 medulloblastoma 17 | 4,104
oligodendroglioma 14 | 2,850
non-small cell lung cancer 13 | 2,890
primitive neuroectodermal tumor 13 | 3,035
breast carcinoma 12 | 1,638
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
invasive ductal carcinoma 12 | 2,951
malignant mesothelioma 12 | 3,232
pancreatic cancer 12 | 2,398
Astrocytoma, Pilocytic 11 | 3,081
Intellectual disability 11 | 1,016
Pick disease 11 | 1,894
lung adenocarcinoma 11 | 2,716
subependymal giant cell astrocytoma 11 | 2,287
tuberculosis 11 | 2,010
Depressive disorder 10 | 409
ductal carcinoma in situ 10 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
Schizophrenia 9 | 1,160
diabetes mellitus 9 | 1,728
Breast Neoplasms 8 | 445
Mammary Neoplasms 8 | 425
astrocytic glioma 8 | 2,597
astrocytoma 8 | 1,146
colon cancer 8 | 1,478
lung carcinoma 8 | 2,843
Dull intelligence 7 | 645
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Poor school performance 7 | 645
Prostatic Neoplasms 7 | 495
Renal Cell Carcinoma 7 | 214
Skin cancer 7 | 469
Stomach Neoplasms 7 | 300
adrenocortical carcinoma 7 | 1,428
group 4 medulloblastoma 7 | 1,855
ulcerative colitis 7 | 1,819
Atopic dermatitis 6 | 952
Bipolar Disorder 6 | 666
Endometrial cancer 6 | 311
Endometriosis 6 | 540
Epilepsy 6 | 792
Melanoma 6 | 711
Obesity 6 | 678
Parkinson's disease 6 | 392
Vascular disease 6 | 319
cystic fibrosis 6 | 1,696
juvenile dermatomyositis 6 | 1,187
nasopharyngeal carcinoma 6 | 1,058
pediatric high grade glioma 6 | 1,064
primary pancreatic ductal adenocarcinoma 6 | 1,109
spina bifida 6 | 1,074
Adenocarcinoma 5 | 122
Alzheimer's disease 5 | 658
Autosomal recessive predisposition 5 | 1,442
Big calvaria 5 | 147
Byzanthine arch palate 5 | 194
Cardiomegaly 5 | 116
Heart disease 5 | 306
Hypoplastic mandible condyle 5 | 275
Increased head circumference 5 | 147
Increased size of cranium 5 | 147
Increased size of skull 5 | 147
Liver cancer 5 | 604
Macroglossia 5 | 65
Mandibular hypoplasia 5 | 275
Mental Depression 5 | 333
Micrognathism 5 | 275
Orbital separation excessive 5 | 244
Osteoporosis 5 | 363
Papule 5 | 43
Rheumatoid arthritis 5 | 1,191
Seizures 5 | 596
Short stature 5 | 531
Splenomegaly 5 | 190
Transitional cell carcinoma of bladder 5 | 17
acute quadriplegic myopathy 5 | 1,158
gastric carcinoma 5 | 807
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
pituitary cancer 5 | 1,972
Acquired scoliosis 4 | 281
Attention deficit hyperactivity disorder 4 | 278
Curvature of spine 4 | 282
Waldenstrons macroglobulinemia 4 | 765
acute myeloid leukemia 4 | 783

Tissue

Digestive Tract 45 | 17,369
Female tissues 45 | 17,400
Male tissues 45 | 17,142
Nervous System 45 | 16,725
Respiratory system 45 | 16,393
Skin and soft tissues 45 | 17,230
Blood and immune system 44 | 16,909
Cardiovascular System 44 | 15,192
Endocrine System 44 | 18,159
Liver and Pancreas 44 | 16,750
Urinary Tract 44 | 16,678

Target Family

Kinase 20 | 634
Non-IDG 18 | 12,091
Enzyme 5 | 4,145
GPCR 2 | 408
Transcription Factor 1 | 1,400

WikiPathways Pathway

Regulation of Microtubule Cyto... 46 | 46
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase MARK2 MARK2 Tchem Kinase -2.49873 272.3 322
Kinesin-like protein KIF2C KIF2C Tbio Non-IDG -2.12404 136.3 256
Rho-associated protein kinase 1 ROCK1 Tclin Kinase -2.64622 378.2 461
Guanine nucleotide-binding protein G(q) subunit alpha GNAQ Tbio Non-IDG -2.73429 514.5 206
Tubulin polymerization-promoting protein TPPP Tbio Non-IDG -1.95532 92.5 179
CAP-Gly domain-containing linker protein 1 CLIP1 Tbio Non-IDG -2.54943 343.7 221
Cell division control protein 42 homolog CDC42 Tchem Enzyme -3.37283 2188.5 380
Sprouty-related, EVH1 domain-containing protein 1 SPRED1 Tbio Non-IDG -1.93963 79.1 299
Proteinase-activated receptor 3 F2RL2 Tbio GPCR -0.33786 2.70 169
CLIP-associating protein 1 CLASP1 Tbio Non-IDG -1.29173 19.3 219