Development Level

Tbio 91 | 11,445
Tchem 33 | 1,598
Tclin 23 | 613
Tdark 2 | 6,588

Collection

Kinase: IDG Consortium (Target... 9 | 125
GPCR: IDG Consortium (Complete... 1 | 25
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 20 | 979
embryonic lethality prior to t... 7 | 278
preweaning lethality, incomple... 7 | 499
abnormal bone structure 6 | 187
abnormal embryo size 6 | 220
embryonic growth retardation 6 | 106
decreased body weight 4 | 161
decreased bone mineral content 4 | 151
edema 4 | 59
abnormal behavior 3 | 298
abnormal cornea morphology 3 | 31
abnormal retina morphology 3 | 71
cataract 3 | 92
decreased circulating alanine ... 3 | 47
decreased grip strength 3 | 116
decreased total body fat amoun... 3 | 207
embryonic lethality prior to o... 3 | 239
enlarged lymph nodes 3 | 37
short tibia 3 | 97
abnormal lens morphology 2 | 81
abnormal pericardium morpholog... 2 | 26
abnormal response to tactile s... 2 | 17
abnormal retinal vasculature m... 2 | 27
abnormal seminal vesicle morph... 2 | 114
corneal opacity 2 | 32
decreased caudal vertebrae num... 2 | 53
decreased circulating aspartat... 2 | 34
decreased circulating creatini... 2 | 39
decreased circulating serum al... 2 | 82
decreased circulating triglyce... 2 | 79
decreased hematocrit 2 | 46
decreased mean corpuscular vol... 2 | 79
decreased spleen weight 2 | 10
enlarged heart 2 | 210
fused cornea and lens 2 | 5
hemorrhage 2 | 23
impaired pupillary reflex 2 | 26
increased circulating alkaline... 2 | 122
increased circulating choleste... 2 | 66
increased mean corpuscular hem... 2 | 36
increased mean corpuscular vol... 2 | 92
pallor 2 | 34
persistence of hyaloid vascula... 2 | 33
prenatal lethality prior to he... 2 | 87
small testis 2 | 58
abnormal body wall morphology 1 | 9
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal gait 1 | 69
abnormal optic disc morphology 1 | 10
abnormal placenta size 1 | 20
abnormal retinal blood vessel ... 1 | 26
abnormal skin coloration 1 | 25
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
abnormal vibrissa morphology 1 | 25
absent startle reflex 1 | 24
cardiovascular system phenotyp... 1 | 36
cleft palate 1 | 8
decreased IgE level 1 | 6
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating phosphat... 1 | 27
decreased circulating potassiu... 1 | 20
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased neutrophil cell numb... 1 | 42
female infertility 1 | 60
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating amylase ... 1 | 25
increased circulating calcium ... 1 | 34
increased circulating free fat... 1 | 20
increased circulating glucose ... 1 | 24
increased circulating potassiu... 1 | 29
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
iris synechia 1 | 3
limb grasping 1 | 41
prenatal lethality 1 | 28
tremors 1 | 39

Disease

Carcinoma 112 | 11,493
ovarian cancer 83 | 8,520
osteosarcoma 81 | 7,950
Cancer 71 | 2,499
glioblastoma 70 | 5,792
medulloblastoma, large-cell 62 | 6,241
psoriasis 60 | 6,694
atypical teratoid / rhabdoid tumor 59 | 5,112
lung cancer 55 | 4,740
Breast cancer 50 | 3,578
ependymoma 49 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 41 | 3,291
invasive ductal carcinoma 40 | 2,951
Kidney cancer 39 | 2,613
adult high grade glioma 39 | 3,801
oligodendroglioma 39 | 2,850
Astrocytoma, Pilocytic 38 | 3,081
group 3 medulloblastoma 38 | 4,104
malignant mesothelioma 37 | 3,232
astrocytic glioma 35 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 33 | 2,989
pancreatic cancer 32 | 2,398
primitive neuroectodermal tumor 32 | 3,035
lung carcinoma 31 | 2,843
group 4 medulloblastoma 29 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 29 | 2,955
subependymal giant cell astrocytoma 29 | 2,287
Schizophrenia 26 | 1,160
lung adenocarcinoma 26 | 2,716
non-small cell lung cancer 26 | 2,890
juvenile dermatomyositis 25 | 1,187
primary pancreatic ductal adenocarcinoma 24 | 1,109
ulcerative colitis 24 | 1,819
Autosomal recessive predisposition 22 | 1,442
breast carcinoma 22 | 1,638
cystic fibrosis 22 | 1,696
tuberculosis 22 | 2,010
Intellectual disability 21 | 1,016
diabetes mellitus 21 | 1,728
ductal carcinoma in situ 21 | 1,745
interstitial cystitis 21 | 2,312
Pick disease 20 | 1,894
Rheumatoid arthritis 19 | 1,191
colon cancer 19 | 1,478
Epilepsy 18 | 792
Orbital separation excessive 18 | 244
acute quadriplegic myopathy 18 | 1,158
pituitary cancer 18 | 1,972
Downward slant of palpebral fissure 17 | 158
Short stature 17 | 531
Cryptorchidism 16 | 296
Dull intelligence 16 | 645
High forehead 16 | 102
Low intelligence 16 | 645
Mental Retardation 16 | 645
Mental deficiency 16 | 645
Poor school performance 16 | 645
Seizures 16 | 596
Tall forehead 16 | 102
Blepharoptosis 15 | 231
Breast Neoplasms 15 | 445
Byzanthine arch palate 15 | 194
Carcinoma, Hepatocellular 15 | 228
Depressive disorder 15 | 409
Liver carcinoma 15 | 240
Mammary Neoplasms 15 | 425
Multiple myeloma 15 | 1,332
Bipolar Disorder 14 | 666
Hypoplastic mandible condyle 14 | 275
Liver Cirrhosis, Experimental 14 | 769
Mandibular hypoplasia 14 | 275
Melanoma 14 | 711
Micrognathism 14 | 275
Muscle hypotonia 14 | 571
Prostatic Neoplasms 14 | 495
Renal Cell Carcinoma 14 | 214
Strabismus 14 | 270
astrocytoma 14 | 1,146
spina bifida 14 | 1,074
Cleft Palate 13 | 271
Cognitive delay 13 | 608
Global developmental delay 13 | 608
Lung Neoplasms 13 | 232
Mental and motor retardation 13 | 608
Neoplasm Metastasis 13 | 168
adrenocortical carcinoma 13 | 1,428
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
pediatric high grade glioma 13 | 1,064
Acquired scoliosis 12 | 281
Curvature of spine 12 | 282
Frontal bossing 12 | 157
Liver cancer 12 | 604
Low-set, posteriorly rotated ears 12 | 110
Neoplasm Invasiveness 12 | 161
Pectus excavatum 12 | 100
Stomach Neoplasms 12 | 300
Waldenstrons macroglobulinemia 12 | 765
esophageal adenocarcinoma 12 | 737
Duchenne muscular dystrophy 11 | 601
cutaneous lupus erythematosus 11 | 1,057

Tissue

Endocrine System 148 | 18,159
Digestive Tract 145 | 17,369
Nervous System 144 | 16,725
Skin and soft tissues 144 | 17,230
Liver and Pancreas 143 | 16,750
Male tissues 143 | 17,142
Urinary Tract 143 | 16,678
Female tissues 142 | 17,400
Blood and immune system 140 | 16,909
Respiratory system 139 | 16,393
Cardiovascular System 132 | 15,192

Target Family

Non-IDG 74 | 12,091
Kinase 44 | 634
Enzyme 22 | 4,145
GPCR 8 | 408
Transporter 1 | 473

WikiPathways Pathway

Regulation of Actin Cytoskelet... 149 | 149
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adenomatous polyposis coli protein 2 APC2 Tbio Non-IDG -1.50271 33.3 93
Moesin MSN Tbio Non-IDG -2.61389 361.7 550
Myosin light chain 1/3, skeletal muscle isoform MYL1 Tbio Non-IDG -2.11698 129.3 109
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
ARF GTPase-activating protein GIT1 GIT1 Tbio Enzyme -1.84352 75.7 358
Fibroblast growth factor 19 FGF19 Tbio Non-IDG -2.54882 334.2 305
Fibroblast growth factor 18 FGF18 Tbio Non-IDG -1.89822 84.6 146
Fibronectin FN1 Tchem Non-IDG -3.09873 1208.8 1583
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328