Development Level

Tbio 81 | 11,445
Tchem 57 | 1,598
Tclin 33 | 613
Tdark 11 | 6,588

Collection

Kinase: IDG Consortium (Target... 6 | 125

IMPC Phenotype

preweaning lethality, complete... 13 | 979
preweaning lethality, incomple... 8 | 499
abnormal bone structure 4 | 187
decreased body weight 4 | 161
increased circulating alkaline... 4 | 122
cataract 3 | 92
decreased circulating choleste... 3 | 93
decreased circulating triglyce... 3 | 79
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
increased circulating sodium l... 3 | 71
increased erythrocyte cell num... 3 | 39
short tibia 3 | 97
abnormal bone mineralization 2 | 38
abnormal coat appearance 2 | 31
abnormal digit morphology 2 | 10
abnormal gait 2 | 69
abnormal lens morphology 2 | 81
abnormal retina morphology 2 | 71
decreased bone mineral content 2 | 151
decreased circulating alkaline... 2 | 46
decreased circulating creatini... 2 | 39
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular hem... 2 | 50
decreased total body fat amoun... 2 | 207
enlarged heart 2 | 210
increased lean body mass 2 | 172
increased leukocyte cell numbe... 2 | 47
increased total body fat amoun... 2 | 134
male infertility 2 | 123
tremors 2 | 39
abnormal behavior 1 | 298
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal forebrain morphology 1 | 10
abnormal hair growth 1 | 10
abnormal midbrain morphology 1 | 10
abnormal pericardium morpholog... 1 | 26
abnormal rib morphology 1 | 10
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal sleep behavior 1 | 70
absent pinna reflex 1 | 23
absent vibrissae 1 | 12
decreased IgG3 level 1 | 1
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating free fat... 1 | 31
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 31
decreased monocyte cell number 1 | 8
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased spleen weight 1 | 10
embryonic growth retardation 1 | 106
enlarged kidney 1 | 14
enlarged spleen 1 | 41
hemorrhage 1 | 23
hypoactivity 1 | 132
increased IgM level 1 | 1
increased T cell number 1 | 6
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased body weight 1 | 25
increased caudal vertebrae num... 1 | 7
increased circulating LDL chol... 1 | 13
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating fructosa... 1 | 13
increased circulating glucose ... 1 | 24
increased circulating potassiu... 1 | 29
increased circulating thyroxin... 1 | 7
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased spleen weight 1 | 10
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
limb grasping 1 | 41
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
small kidney 1 | 16
small superior vagus ganglion 1 | 74
thrombocytosis 1 | 27

Disease

Carcinoma 127 | 11,493
ovarian cancer 99 | 8,520
osteosarcoma 96 | 7,950
Cancer 90 | 2,499
glioblastoma 86 | 5,792
medulloblastoma, large-cell 84 | 6,241
psoriasis 76 | 6,694
atypical teratoid / rhabdoid tumor 72 | 5,112
lung cancer 68 | 4,740
ependymoma 65 | 4,679
adult high grade glioma 57 | 3,801
group 3 medulloblastoma 57 | 4,104
Breast cancer 55 | 3,578
oligodendroglioma 51 | 2,850
Kidney cancer 48 | 2,613
Astrocytoma, Pilocytic 47 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 46 | 3,291
invasive ductal carcinoma 46 | 2,951
non-small cell lung cancer 46 | 2,890
primitive neuroectodermal tumor 46 | 3,035
astrocytic glioma 43 | 2,597
malignant mesothelioma 43 | 3,232
pancreatic cancer 40 | 2,398
lung carcinoma 39 | 2,843
Schizophrenia 38 | 1,160
lung adenocarcinoma 38 | 2,716
subependymal giant cell astrocytoma 38 | 2,287
intraductal papillary-mucinous adenoma (IPMA) 35 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 35 | 2,989
interstitial cystitis 33 | 2,312
ulcerative colitis 32 | 1,819
Pick disease 31 | 1,894
diabetes mellitus 30 | 1,728
Intellectual disability 29 | 1,016
group 4 medulloblastoma 29 | 1,855
pituitary cancer 28 | 1,972
Epilepsy 27 | 792
Bipolar Disorder 23 | 666
Dull intelligence 23 | 645
Low intelligence 23 | 645
Mental Retardation 23 | 645
Mental deficiency 23 | 645
Poor school performance 23 | 645
adrenocortical carcinoma 23 | 1,428
cystic fibrosis 23 | 1,696
juvenile dermatomyositis 23 | 1,187
tuberculosis 23 | 2,010
Melanoma 22 | 711
Short stature 22 | 531
breast carcinoma 22 | 1,638
Depressive disorder 21 | 409
Multiple myeloma 21 | 1,332
Renal Cell Carcinoma 21 | 214
astrocytoma 21 | 1,146
primary pancreatic ductal adenocarcinoma 21 | 1,109
Orbital separation excessive 20 | 244
Seizures 20 | 596
ductal carcinoma in situ 20 | 1,745
spina bifida 20 | 1,074
Autosomal recessive predisposition 19 | 1,442
Blepharoptosis 19 | 231
Breast Neoplasms 19 | 445
Byzanthine arch palate 19 | 194
Mammary Neoplasms 19 | 425
Toxic encephalopathy 19 | 141
Alzheimer's disease 18 | 658
Cognitive delay 18 | 608
Global developmental delay 18 | 608
Mental and motor retardation 18 | 608
Stomach Neoplasms 18 | 300
Strabismus 18 | 270
colon cancer 18 | 1,478
Cryptorchidism 17 | 296
Downward slant of palpebral fissure 17 | 158
Lung Neoplasms 17 | 232
Muscle hypotonia 17 | 571
Rheumatoid arthritis 17 | 1,191
Skin cancer 17 | 469
cutaneous lupus erythematosus 17 | 1,057
pancreatic ductal adenocarcinoma liver metastasis 17 | 1,962
Acquired scoliosis 16 | 281
Curvature of spine 16 | 282
Hypoplastic mandible condyle 16 | 275
Mandibular hypoplasia 16 | 275
Micrognathism 16 | 275
Noonan syndrome 16 | 34
Concave bridge of nose 15 | 195
Depressed nasal bridge 15 | 195
Depressed nasal root/bridge 15 | 195
Heart disease 15 | 306
High forehead 15 | 102
Tall forehead 15 | 102
Delayed bone age 14 | 136
Low-set, posteriorly rotated ears 14 | 110
Mental Depression 14 | 333
Parkinson's disease 14 | 392
Pectus excavatum 14 | 100
Prostatic Neoplasms 14 | 495
esophageal adenocarcinoma 14 | 737
primary Sjogren syndrome 13 | 735

Tissue

Digestive Tract 181 | 17,369
Endocrine System 180 | 18,159
Blood and immune system 179 | 16,909
Skin and soft tissues 179 | 17,230
Male tissues 177 | 17,142
Female tissues 176 | 17,400
Liver and Pancreas 175 | 16,750
Nervous System 174 | 16,725
Urinary Tract 174 | 16,678
Respiratory system 173 | 16,393
Cardiovascular System 166 | 15,192

Target Family

Non-IDG 61 | 12,091
Kinase 57 | 634
Enzyme 53 | 4,145
Transcription Factor 7 | 1,400
Ion Channel 3 | 344
GPCR 1 | 408

WikiPathways Pathway

Ras Signaling 182 | 182
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras association domain-containing protein 5 RASSF5 Tbio Non-IDG -1.81149 71.3 155
Ras/Rap GTPase-activating protein SynGAP SYNGAP1 Tbio Enzyme -1.91757 81.2 178
Ras GTPase-activating protein nGAP RASAL2 Tbio Enzyme -1.51440 33.0 99
High affinity nerve growth factor receptor NTRK1 Tclin Kinase -3.05841 1050.9 1092
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 GNG8 Tdark Non-IDG -2.17483 154.8 34
Abelson tyrosine-protein kinase 2 ABL2 Tchem Kinase -1.86293 71.2 358
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Cytosolic phospholipase A2 gamma PLA2G4C Tchem Enzyme -1.27690 20.9 63